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Asish K Ghosh

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentStephenson Cancer Center
AddressBRC 417B
975 NE 10th St
Oklahoma City OK 73104
ORCID ORCID Icon0000-0002-4885-094X Additional info
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    Collapse Biography 
    Collapse education and training
    University of Calcutta, IndiaPh.D.1998Biochemistry

    Collapse Research 
    Collapse research activities and funding
    R21CA280437     (GHOSH, ASISH KUMAR)Apr 10, 2023 - Mar 31, 2025
    NIH/NCI
    Pro-Oncogenic Role of a Mitochondrial Lipid Kinase in CLL
    Role: Principal Investigator
    R21CA280437     (GHOSH, ASISH KUMAR)Apr 10, 2023 - Mar 31, 2025
    NIH
    Pro-Oncogenic Role of a Mitochondrial Lipid Kinase in CLL
    Role: Principal Investigator
    R21CA274072     (GHOSH, ASISH KUMAR)Jul 7, 2022 - Jun 30, 2024
    NIH
    Study Pro-Oncogenic Role of BCL6 in CLL Tumorigenesis
    Role: Principal Investigator
    R21CA274072-01     (GHOSH, ASISH KUMAR)Jul 7, 2022 - Jun 30, 2024
    NIH/NCI
    Study Pro-Oncogenic Role of BCL6 in CLL Tumorigenesis
    Role: Principal Investigator
    R01CA170006     (GHOSH, ASISH KUMAR)Aug 1, 2013 - May 31, 2020
    NIH
    Microvesicle Dynamics in B-Cell Chronic Lymphocytic Leukemia Tumor Microenvironme
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lytton SD, Ghosh AK. SARS-CoV-2 Variants and COVID-19 in Bangladesh-Lessons Learned. Viruses. 2024 Jul 04; 16(7). PMID: 39066238; PMCID: PMC11281597.
      Citations:    Fields:    Translation:HumansCells
    2. Sinha S, Guo R, Del Busso MD, Han W, Boysen J, Wellik LE, Ghosh AK, Kay NE. Aberrant activation of AXL may drive progression of squamous cell carcinoma in CLL patients: a mechanistic study with clinical implications. Br J Cancer. 2024 Aug; 131(3):589-600. PMID: 38886556; PMCID: PMC11300914.
      Citations:    Fields:    Translation:HumansCells
    3. Lytton SD, Ghosh AK, Bulbul RH, Nasifa T, Mamunur R, Meier C, Landt O, Kaiser M. The severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) omicron sub-variants in Bangladesh cause mild COVID-19 and associate with similar antibody responses irrespective of natural infection or vaccination history. Heliyon. 2024 May 30; 10(10):e31011. PMID: 38770337; PMCID: PMC11103536.
      Citations: 1     
    4. Benfer KA, Whittingham K, Ware RS, Ghosh AK, Chowdhury S, Moula G, Samanta S, Khan NZ, Bell KL, Oftedal S, Bandaranayake S, Salt AT, Bhattacharya A, Maiti P, Tripathi SK, Morgan C, Novak I, Boyd RN. Efficacy of Early Intervention for Infants With Cerebral Palsy in an LMIC: An RCT. Pediatrics. 2024 Apr 01; 153(4). PMID: 38516717.
      Citations: 1     Fields:    Translation:Humans
    5. Rottmann M, Yoo S, Pfenniger A, Mikhailov A, Benefield B, Johnson DA, Zhang W, Ghosh AK, Kim D, Passman R, Knight BP, Lee DC, Arora R. Use of Atrial Fibrillation Electrograms and T1/T2 Magnetic Resonance Imaging to Define the Progressive Nature of Molecular and Structural Remodeling - A New Paradigm Underlying the Emergence of Persistent Atrial Fibrillation. J Am Heart Assoc. 2023 Nov 06; e9011. PMID: 37930082.
      Citations:    Fields:    Translation:Animals
    6. Mamidi MK, Mahmud H, Maiti GP, Mendez MT, Fernandes SM, Vesely SK, Holter-Chakrabarty J, Brown JR, Ghosh AK. Idelalisib activates AKT via increased recruitment of PI3Kd/PI3Kß to BCR signalosome while reducing PDK1 in post-therapy CLL cells. Leukemia. 2022 07; 36(7):1806-1817. PMID: 35568768.
      Citations: 2     Fields:    Translation:Humans
    7. Maiti GP, Sinha S, Mahmud H, Boysen J, Mendez MT, Vesely SK, Holter-Chakrabarty J, Kay NE, Ghosh AK. SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis. Blood Cancer J. 2021 05 17; 11(5):93. PMID: 34001853.
      Citations: 6     Fields:    Translation:HumansCells
    8. Sinha S, Secreto CR, Boysen JC, Lesnick C, Wang Z, Ding W, Call TG, Kenderian SJ, Parikh SA, Warner SL, Bearss DJ, Ghosh AK, Kay NE. Upregulation of AXL and ß-catenin in chronic lymphocytic leukemia cells cultured with bone marrow stroma cells is associated with enhanced drug resistance. Blood Cancer J. 2021 02 18; 11(2):37. PMID: 33602892.
      Citations: 2     Fields:    Translation:HumansCells
    9. Mahmud H, Mendez M, Mukhopadhyay B, Holter-Chakrabarty J, Ghosh AK. HSP90 overexpression potentiates the B-cell receptor and fibroblast growth factor receptor survival signals in chronic lymphocytic leukemia cells. Oncotarget. 2020 Jun 02; 11(22):2037-2046. PMID: 32547702.
      Citations: 2     Fields:    
    10. Sinha S, Boysen JC, Chaffee KG, Kabat BF, Slager SL, Parikh SA, Secreto CR, Call T, Shanafelt TD, Leis JF, Warner SL, Bearss DJ, Ghosh AK, Kay NE. Chronic lymphocytic leukemia cells from ibrutinib treated patients are sensitive to Axl receptor tyrosine kinase inhibitor therapy. Oncotarget. 2018 Dec 14; 9(98):37173-37184. PMID: 30647852.
      Citations: 9     Fields:    
    11. Maiti GP, Kay NE, Ghosh AK. Microvesicles in CLL: predictor of disease progression/relapse. Oncotarget. 2017 Oct 31; 8(53):90632-90633. PMID: 29207590.
      Citations: 1     Fields:    
    12. Kay NE, Sassoon T, Secreto C, Sinha S, Shanafelt TD, Ghosh AK, Arbiser JL. Tris (dibenzylideneacetone) dipalladium: a small-molecule palladium complex is effective in inducing apoptosis in chronic lymphocytic leukemia B-cells. Leuk Lymphoma. 2016 10; 57(10):2409-16. PMID: 27189785.
      Citations: 8     Fields:    Translation:HumansCells
    13. Sinha S, Boysen J, Nelson M, Secreto C, Warner SL, Bearss DJ, Lesnick C, Shanafelt TD, Kay NE, Ghosh AK. Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors. Clin Cancer Res. 2015 May 01; 21(9):2115-26. PMID: 25673699.
      Citations: 44     Fields:    Translation:HumansCells
    14. Ferrajoli A, Shanafelt TD, Ivan C, Shimizu M, Rabe KG, Nouraee N, Ikuo M, Ghosh AK, Lerner S, Rassenti LZ, Xiao L, Hu J, Reuben JM, Calin S, You MJ, Manning JT, Wierda WG, Estrov Z, O'Brien S, Kipps TJ, Keating MJ, Kay NE, Calin GA. Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia. Blood. 2013 Sep 12; 122(11):1891-9. PMID: 23821659.
      Citations: 102     Fields:    Translation:HumansCells
    15. Ghosh AK, Kay NE. Critical signal transduction pathways in CLL. Adv Exp Med Biol. 2013; 792:215-39. PMID: 24014299.
      Citations: 6     Fields:    Translation:HumansCells
    16. Shanafelt TD, Call TG, Zent CS, Leis JF, LaPlant B, Bowen DA, Roos M, Laumann K, Ghosh AK, Lesnick C, Lee MJ, Yang CS, Jelinek DF, Erlichman C, Kay NE. Phase 2 trial of daily, oral Polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia. Cancer. 2013 Jan 15; 119(2):363-70. PMID: 22760587.
      Citations: 76     Fields:    Translation:HumansCTClinical Trials
    17. Ghosh AK, Secreto C, Boysen J, Sassoon T, Shanafelt TD, Mukhopadhyay D, Kay NE. The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy. Blood. 2011 Feb 10; 117(6):1928-37. PMID: 21135257.
      Citations: 64     Fields:    Translation:HumansCells
    18. Shanafelt T, Zent C, Byrd J, Erlichman C, Laplant B, Ghosh A, Call T, Villalona-Calero M, Jelinek D, Bowen D, Laumann K, Wu W, Hanson C, Kay N. Phase II trials of single-agent anti-VEGF therapy for patients with chronic lymphocytic leukemia. Leuk Lymphoma. 2010 Dec; 51(12):2222-9. PMID: 21054149.
      Citations: 11     Fields:    Translation:HumansCTClinical Trials
    19. Ghosh AK, Secreto CR, Knox TR, Ding W, Mukhopadhyay D, Kay NE. Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression. Blood. 2010 Mar 04; 115(9):1755-64. PMID: 20018914.
      Citations: 114     Fields:    Translation:HumansCells
    20. Sinha S, Dutta S, Datta K, Ghosh AK, Mukhopadhyay D. Von Hippel-Lindau gene product modulates TIS11B expression in renal cell carcinoma: impact on vascular endothelial growth factor expression in hypoxia. J Biol Chem. 2009 Nov 20; 284(47):32610-8. PMID: 19801654.
      Citations: 16     Fields:    Translation:HumansCells
    21. Ding W, Nowakowski GS, Knox TR, Boysen JC, Maas ML, Schwager SM, Wu W, Wellik LE, Dietz AB, Ghosh AK, Secreto CR, Medina KL, Shanafelt TD, Zent CS, Call TG, Kay NE. Bi-directional activation between mesenchymal stem cells and CLL B-cells: implication for CLL disease progression. Br J Haematol. 2009 Nov; 147(4):471-83. PMID: 19751240.
      Citations: 40     Fields:    Translation:HumansCells
    22. Shanafelt TD, Call TG, Zent CS, LaPlant B, Bowen DA, Roos M, Secreto CR, Ghosh AK, Kabat BF, Lee MJ, Yang CS, Jelinek DF, Erlichman C, Kay NE. Phase I trial of daily oral Polyphenon E in patients with asymptomatic Rai stage 0 to II chronic lymphocytic leukemia. J Clin Oncol. 2009 Aug 10; 27(23):3808-14. PMID: 19470922.
      Citations: 73     Fields:    Translation:HumansCTClinical Trials
    23. Ghosh AK, Shanafelt TD, Cimmino A, Taccioli C, Volinia S, Liu CG, Calin GA, Croce CM, Chan DA, Giaccia AJ, Secreto C, Wellik LE, Lee YK, Mukhopadhyay D, Kay NE. Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells. Blood. 2009 May 28; 113(22):5568-74. PMID: 19336759.
      Citations: 58     Fields:    Translation:HumansCells
    24. Ghosh AK, Kay NE, Secreto CR, Shanafelt TD. Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG. Clin Cancer Res. 2009 Feb 15; 15(4):1250-8. PMID: 19228728.
      Citations: 48     Fields:    Translation:HumansCells
    25. Ghosh AK, Kanda T, Steele R, Ray RB. Knockdown of MBP-1 in human foreskin fibroblasts induces p53-p21 dependent senescence. PLoS One. 2008; 3(10):e3384. PMID: 18852884.
      Citations: 6     Fields:    Translation:HumansCells
    26. Ghosh AK, Steele R, Ryerse J, Ray RB. Tumor-suppressive effects of MBP-1 in non-small cell lung cancer cells. Cancer Res. 2006 Dec 15; 66(24):11907-12. PMID: 17178888.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    27. Ghosh AK, Steele R, Ray RB. Knockdown of MBP-1 in human prostate cancer cells delays cell cycle progression. J Biol Chem. 2006 Aug 18; 281(33):23652-7. PMID: 16762917.
      Citations: 8     Fields:    Translation:HumansCells
    28. Ghosh AK, Steele R, Ray RB. Carboxyl-terminal repressor domain of MBP-1 is sufficient for regression of prostate tumor growth in nude mice. Cancer Res. 2005 Feb 01; 65(3):718-21. PMID: 15705866.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    29. Ghosh AK, Steele R, Ray RB. c-myc Promoter-binding protein 1 (MBP-1) regulates prostate cancer cell growth by inhibiting MAPK pathway. J Biol Chem. 2005 Apr 08; 280(14):14325-30. PMID: 15805119.
      Citations: 22     Fields:    Translation:HumansCells
    30. Sarcar B, Ghosh AK, Steele R, Ray R, Ray RB. Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase. Virology. 2004 Apr 25; 322(1):51-60. PMID: 15063116.
      Citations: 23     Fields:    Translation:HumansCells
    31. Ray RB, Basu A, Steele R, Beyene A, McHowat J, Meyer K, Ghosh AK, Ray R. Ebola virus glycoprotein-mediated anoikis of primary human cardiac microvascular endothelial cells. Virology. 2004 Apr 10; 321(2):181-8. PMID: 15051379.
      Citations: 23     Fields:    Translation:HumansCells
    32. Majumder M, Steele R, Ghosh AK, Zhou XY, Thornburg L, Ray R, Phillips NJ, Ray RB. Expression of hepatitis C virus non-structural 5A protein in the liver of transgenic mice. FEBS Lett. 2003 Dec 18; 555(3):528-32. PMID: 14675768.
      Citations: 21     Fields:    Translation:Animals
    33. Sen A, Steele R, Ghosh AK, Basu A, Ray R, Ray RB. Inhibition of hepatitis C virus protein expression by RNA interference. Virus Res. 2003 Oct; 96(1-2):27-35. PMID: 12951263.
      Citations: 19     Fields:    Translation:HumansCells
    34. Ghosh AK, Steele R, Ray RB. Modulation of human luteinizing hormone beta gene transcription by MIP-2A. J Biol Chem. 2003 Jun 27; 278(26):24033-8. PMID: 12700240.
      Citations: 5     Fields:    Translation:HumansCells
    35. Mukherjee P, Ghosh AK, Ghose AC. Infection pattern and immune response in the spleen and liver of BALB/c mice intracardially infected with Leishmania donovani amastigotes. Immunol Lett. 2003 Apr 03; 86(2):131-8. PMID: 12644314.
      Citations: 18     Fields:    Translation:AnimalsCells
    36. Ghosh AK, Majumder M, Steele R, Ray R, Ray RB. Modulation of interferon expression by hepatitis C virus NS5A protein and human homeodomain protein PTX1. Virology. 2003 Feb 01; 306(1):51-9. PMID: 12620797.
      Citations: 5     Fields:    Translation:HumansCells
    37. Ray RB, Steele R, Basu A, Meyer K, Majumder M, Ghosh AK, Ray R. Distinct functional role of Hepatitis C virus core protein on NF-kappaB regulation is linked to genomic variation. Virus Res. 2002 Jul; 87(1):21-9. PMID: 12135786.
      Citations: 12     Fields:    Translation:HumansCells
    38. Ghosh AK, Majumder M, Steele R, Liu TJ, Ray RB. MBP-1 mediated apoptosis involves cytochrome c release from mitochondria. Oncogene. 2002 Apr 25; 21(18):2775-84. PMID: 11973636.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    39. Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB. Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice. Virology. 2002 Mar 01; 294(1):94-105. PMID: 11886269.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
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