"Focal Adhesions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An anchoring junction of the cell to a non-cellular substrate. It is composed of a specialized area of the plasma membrane where bundles of the ACTIN CYTOSKELETON terminate and attach to the transmembrane linkers, INTEGRINS, which in turn attach through their extracellular domains to EXTRACELLULAR MATRIX PROTEINS.
| Descriptor ID |
D022001
|
| MeSH Number(s) |
A11.284.149.165.165.285
|
| Concept/Terms |
Focal Adhesions- Focal Adhesions
- Adhesion, Focal
- Adhesions, Focal
- Focal Adhesion
- Focal Contacts
- Contact, Focal
- Contacts, Focal
- Focal Contact
- Adhesion Plaques
- Adhesion Plaque
- Plaque, Adhesion
- Plaques, Adhesion
- Cell-Matrix Adherens Junctions
- Adherens Junction, Cell-Matrix
- Adherens Junctions, Cell-Matrix
- Cell Matrix Adherens Junctions
- Cell-Matrix Adherens Junction
- Junction, Cell-Matrix Adherens
- Junctions, Cell-Matrix Adherens
|
Below are MeSH descriptors whose meaning is more general than "Focal Adhesions".
Below are MeSH descriptors whose meaning is more specific than "Focal Adhesions".
This graph shows the total number of publications written about "Focal Adhesions" by people in this website by year, and whether "Focal Adhesions" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 0 | 2 | 2 |
| 2015 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Focal Adhesions" by people in Profiles.
-
DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma. Oncotarget. 2015 Feb 10; 6(4):2193-205.
-
LPA-mediated migration of ovarian cancer cells involves translocalization of Gai2 to invadopodia and association with Src and ß-pix. Cancer Lett. 2015 Jan 28; 356(2 Pt B):382-91.
-
The TMEFF2 tumor suppressor modulates integrin expression, RhoA activation and migration of prostate cancer cells. Biochim Biophys Acta. 2014 Jun; 1843(6):1216-24.
-
Whole animal knockout of smooth muscle alpha-actin does not alter excisional wound healing or the fibroblast-to-myofibroblast transition. Wound Repair Regen. 2013 Jan-Feb; 21(1):166-76.
-
Myocardin-related transcription factors A and B are key regulators of TGF-ß1-induced fibroblast to myofibroblast differentiation. J Invest Dermatol. 2011 Dec; 131(12):2378-85.
-
The regulation of integrin-mediated osteoblast focal adhesion and focal adhesion kinase expression by nanoscale topography. Biomaterials. 2007 Apr; 28(10):1787-97.