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RPE65 gene delivery restores isomerohydrolase activity and prevents early cone loss in Rpe65-/- mice.
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RPE65 gene delivery restores isomerohydrolase activity and prevents early cone loss in Rpe65-/- mice.
RPE65 gene delivery restores isomerohydrolase activity and prevents early cone loss in Rpe65-/- mice. Invest Ophthalmol Vis Sci. 2006 Mar; 47(3):1177-84.
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subject areas
Adenoviridae
Adenoviridae
Animals
Animals
Blotting, Western
Blotting, Western
Carrier Proteins
Carrier Proteins
Chromatography, High Pressure Liquid
Chromatography, High Pressure Liquid
cis-trans-Isomerases
cis-trans-Isomerases
Dark Adaptation
Dark Adaptation
Eye Proteins
Eye Proteins
Fluorescent Antibody Technique, Indirect
Fluorescent Antibody Technique, Indirect
Gene Expression
Gene Expression
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Enzymologic
Genetic Therapy
Genetic Therapy
Humans
Humans
Mice
Mice
Mice, Inbred C57BL
Mice, Inbred C57BL
Mice, Knockout
Mice, Knockout
Retinal Cone Photoreceptor Cells
Retinal Cone Photoreceptor Cells
Retinal Degeneration
Retinal Degeneration
Retinaldehyde
Retinaldehyde
Reverse Transcriptase Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Rod Opsins
Rod Opsins
Transducin
Transducin
Vitamin A
Vitamin A