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Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells.
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Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells.
Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res. 2006 Feb 15; 66(4):2116-28.
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subject areas
Aged
Aged
Bronchi
Bronchi
Cell Adhesion
Cell Adhesion
Cell Growth Processes
Cell Growth Processes
Cell Transformation, Neoplastic
Cell Transformation, Neoplastic
Dual Specificity Phosphatase 6
Dual Specificity Phosphatase 6
Epidermal Growth Factor
Epidermal Growth Factor
Epithelial Cells
Epithelial Cells
ErbB Receptors
ErbB Receptors
Erlotinib Hydrochloride
Erlotinib Hydrochloride
Female
Female
Genes, erbB-1
Genes, erbB-1
Genes, p16
Genes, p16
Genes, p53
Genes, p53
Genes, ras
Genes, ras
Humans
Humans
Lung Neoplasms
Lung Neoplasms
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinase Kinases
Oncogenes
Oncogenes
Phosphorylation
Phosphorylation
Protein Tyrosine Phosphatases
Protein Tyrosine Phosphatases
Proto-Oncogene Proteins c-akt
Proto-Oncogene Proteins c-akt
Quinazolines
Quinazolines
RNA Interference
RNA Interference
STAT3 Transcription Factor
STAT3 Transcription Factor
Telomerase
Telomerase
Transfection
Transfection
Up-Regulation
Up-Regulation
authors with profiles
Melville B Vaughan