Vaccine-induced antibodies target sequestered viral antigens to prevent ocular HSV-1 pathogenesis, preserve vision, and preempt productive neuronal infection.
Vaccine-induced antibodies target sequestered viral antigens to prevent ocular HSV-1 pathogenesis, preserve vision, and preempt productive neuronal infection. Mucosal Immunol. 2019 05; 12(3):827-839.
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Animals
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Animals
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Antibodies, Viral
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Antibodies, Viral
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Antigens, Viral
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Antigens, Viral
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Complement C3
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Complement C3
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Cornea
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Cornea
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Eye Diseases
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Eye Diseases
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Herpes Simplex
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Herpes Simplex
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Herpesvirus 1, Human
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Herpesvirus 1, Human
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Humans
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Humans
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Immunity, Humoral
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Immunity, Humoral
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Mice
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Mice
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Mice, Inbred C57BL
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Mice, Inbred C57BL
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Mice, Knockout
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Mice, Knockout
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Neurons
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Neurons
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T-Lymphocytes
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T-Lymphocytes
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Vaccination
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Vaccination
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Viral Vaccines
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Viral Vaccines
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Vision, Ocular
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Vision, Ocular