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Safety evaluation of intravenously administered mono-thioated aptamer against E-selectin in mice.
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Safety evaluation of intravenously administered mono-thioated aptamer against E-selectin in mice.
Safety evaluation of intravenously administered mono-thioated aptamer against E-selectin in mice. Toxicol Appl Pharmacol. 2015 Aug 15; 287(1):86-92.
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PubMed
subject areas
Alanine Transaminase
Alanine Transaminase
Animals
Animals
Antineoplastic Agents
Antineoplastic Agents
Aptamers, Nucleotide
Aptamers, Nucleotide
Aspartate Aminotransferases
Aspartate Aminotransferases
Biomarkers
Biomarkers
Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury
Complement C3a
Complement C3a
Complement C5a
Complement C5a
Cytokines
Cytokines
Dose-Response Relationship, Drug
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Administration Schedule
E-Selectin
E-Selectin
Female
Female
Injections, Intravenous
Injections, Intravenous
Kidney
Kidney
Liver
Liver
Male
Male
Mice, Inbred ICR
Mice, Inbred ICR
Necrosis
Necrosis
Risk Assessment
Risk Assessment
authors with profiles
Yan Daniel Zhao
Takemi Tanaka
Wajeeha Razaq