Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase.

Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase. Eur J Med Chem. 2020 Aug 15; 200:112412.

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subject areas

Binding Sites
Binding Sites
Drug Design
Drug Design
Enzyme Inhibitors
Enzyme Inhibitors
Microbial Sensitivity Tests
Microbial Sensitivity Tests
Staphylococcus aureus
Staphylococcus aureus
Structure-Activity Relationship
Structure-Activity Relationship
Tetrahydrofolate Dehydrogenase
Tetrahydrofolate Dehydrogenase
Trimethoprim
Trimethoprim

authors with profiles

Christina Bourne
Kenneth Darrell Berlin