DNA Topoisomerases, Type I
"DNA Topoisomerases, Type I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
| Descriptor ID |
D004264
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| MeSH Number(s) |
D08.811.399.403.483 D12.776.157.687.375 D12.776.660.720.375
|
| Concept/Terms |
DNA Topoisomerases, Type I- DNA Topoisomerases, Type I
- DNA Nicking-Closing Proteins
- DNA Relaxing Enzyme
- DNA Relaxing Enzymes
- DNA Relaxing Protein
- DNA Topoisomerase
- DNA Topoisomerase I
- DNA Type 1 Topoisomerase
- DNA Untwisting Enzyme
- DNA Untwisting Enzymes
- DNA Untwisting Protein
- DNA Untwisting Proteins
- Topoisomerase I
- Type I DNA Topoisomerase
- DNA Nicking-Closing Protein
|
Below are MeSH descriptors whose meaning is more general than "DNA Topoisomerases, Type I".
Below are MeSH descriptors whose meaning is more specific than "DNA Topoisomerases, Type I".
This graph shows the total number of publications written about "DNA Topoisomerases, Type I" by people in this website by year, and whether "DNA Topoisomerases, Type I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 3 | 3 |
| 2002 | 1 | 0 | 1 |
| 2016 | 0 | 2 | 2 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA Topoisomerases, Type I" by people in Profiles.
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E-pharmacophore guided discovery of pyrazolo[1,5-c]quinazolines as dual inhibitors of topoisomerase-I and histone deacetylase. Bioorg Chem. 2020 01; 94:103409.
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Topoisomerase expression and amplification in solid tumours: Analysis of 24,262 patients. Eur J Cancer. 2017 09; 83:80-87.
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Autoantibody-Positive Healthy Individuals Display Unique Immune Profiles That May Regulate Autoimmunity. Arthritis Rheumatol. 2016 10; 68(10):2492-502.
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The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair. Nucleic Acids Res. 2016 Feb 29; 44(4):1718-31.
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The mechanism of type IA topoisomerases. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12126-31.
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Identification of a mammalian RNA polymerase I holoenzyme containing components of the DNA repair/replication system. Nucleic Acids Res. 1999 Sep 15; 27(18):3720-7.
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13S condensin actively reconfigures DNA by introducing global positive writhe: implications for chromosome condensation. Cell. 1999 Jul 23; 98(2):239-48.
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Mechanisms of separation of the complementary strands of DNA during replication. Genetica. 1999; 106(1-2):131-40.