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Design, synthesis and preclinical evaluation of 5-methyl-N4-aryl-furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential.
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Design, synthesis and preclinical evaluation of 5-methyl-N4-aryl-furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential.
Design, synthesis and preclinical evaluation of 5-methyl-N4-aryl-furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential. Bioorg Med Chem Lett. 2018 10 01; 28(18):3085-3093.
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PubMed
subject areas
Animals
Animals
Antineoplastic Agents
Antineoplastic Agents
Cell Line, Tumor
Cell Line, Tumor
Cell Proliferation
Cell Proliferation
Dose-Response Relationship, Drug
Dose-Response Relationship, Drug
Drug Design
Drug Design
Drug Screening Assays, Antitumor
Drug Screening Assays, Antitumor
ErbB Receptors
ErbB Receptors
Humans
Humans
Mice
Mice
Molecular Docking Simulation
Molecular Docking Simulation
Molecular Structure
Molecular Structure
Neoplasms, Experimental
Neoplasms, Experimental
Protein Kinase Inhibitors
Protein Kinase Inhibitors
Pyrimidines
Pyrimidines
Receptor, Platelet-Derived Growth Factor beta
Receptor, Platelet-Derived Growth Factor beta
Structure-Activity Relationship
Structure-Activity Relationship
Vascular Endothelial Growth Factor Receptor-2
Vascular Endothelial Growth Factor Receptor-2
authors with profiles
Michael Ihnat