Co-Authors
This is a "connection" page, showing publications co-authored by Christina Bourne and Kenneth Berlin.
Connection Strength
0.857
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Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase. Eur J Med Chem. 2020 Aug 15; 200:112412.
Score: 0.171
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The structure and competitive substrate inhibition of dihydrofolate reductase from Enterococcus faecalis reveal restrictions to cofactor docking. Biochemistry. 2014 Feb 25; 53(7):1228-38.
Score: 0.111
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Structure-activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase. Biochim Biophys Acta. 2013 Jan; 1834(1):46-52.
Score: 0.101
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Classifying compound mechanism of action for linking whole cell phenotypes to molecular targets. J Mol Recognit. 2012 Apr; 25(4):216-23.
Score: 0.098
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Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. Antimicrob Agents Chemother. 2010 Sep; 54(9):3825-33.
Score: 0.086
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Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity. Antimicrob Agents Chemother. 2009 Jul; 53(7):3065-73.
Score: 0.079
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Evaluation of New Dihydrophthalazine-Appended 2,4-Diaminopyrimidines against Bacillus anthracis: Improved Syntheses Using a New Pincer Complex. Molecules. 2015 Apr 21; 20(4):7222-44.
Score: 0.030
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Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis. Bioorg Med Chem. 2015 Jan 01; 23(1):203-11.
Score: 0.029
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Synthesis and biological evaluation of 2,4-diaminopyrimidine-based antifolate drugs against Bacillus anthracis. Molecules. 2014 Mar 17; 19(3):3231-46.
Score: 0.028
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Comparative Study of the Frech Catalyst with Two Conventional Catalysts in the Heck Synthesis of 2,4-Diaminopyrimidine-based Antibiotics. Org Prep Proced Int. 2013; 45(1):66-71.
Score: 0.026
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Inhibition of bacterial dihydrofolate reductase by 6-alkyl-2,4-diaminopyrimidines. ChemMedChem. 2012 Nov; 7(11):1974-82.
Score: 0.025
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Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis. Eur J Med Chem. 2012 Aug; 54:387-96.
Score: 0.025
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Approaches to Iodinated Derivatives of Vanillin and Isovanillin. Org Prep Proced Int. 2012; 44(2):146-152.
Score: 0.024
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Microwave-assisted Heck Synthesis of Substituted 2,4-Diaminopyrimidine-based Antibiotics. Org Prep Proced Int. 2012; 44(3):281-287.
Score: 0.024