Christina Bourne to Tetrahydrofolate Dehydrogenase
This is a "connection" page, showing publications Christina Bourne has written about Tetrahydrofolate Dehydrogenase.
Connection Strength
2.533
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Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase. Eur J Med Chem. 2020 Aug 15; 200:112412.
Score: 0.706
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The structure and competitive substrate inhibition of dihydrofolate reductase from Enterococcus faecalis reveal restrictions to cofactor docking. Biochemistry. 2014 Feb 25; 53(7):1228-38.
Score: 0.457
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Structure-activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase. Biochim Biophys Acta. 2013 Jan; 1834(1):46-52.
Score: 0.415
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Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. Antimicrob Agents Chemother. 2010 Sep; 54(9):3825-33.
Score: 0.356
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Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity. Antimicrob Agents Chemother. 2009 Jul; 53(7):3065-73.
Score: 0.327
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Identification of novel potential antibiotics against Staphylococcus using structure-based drug screening targeting dihydrofolate reductase. J Chem Inf Model. 2014 Apr 28; 54(4):1242-53.
Score: 0.115
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Inhibition of bacterial dihydrofolate reductase by 6-alkyl-2,4-diaminopyrimidines. ChemMedChem. 2012 Nov; 7(11):1974-82.
Score: 0.103
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Synthesis and biological evaluation of 2,4-diaminopyrimidine-based antifolate drugs against Bacillus anthracis. Molecules. 2014 Mar 17; 19(3):3231-46.
Score: 0.029
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Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis. Eur J Med Chem. 2012 Aug; 54:387-96.
Score: 0.025