Rodney Tweten to Bacterial Toxins
This is a "connection" page, showing publications Rodney Tweten has written about Bacterial Toxins.
Connection Strength
7.673
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How protein engineering has revealed the molecular mechanisms of pore-forming toxins. Methods Enzymol. 2021; 649:47-70.
Score: 0.575
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An Intermolecular p-Stacking Interaction Drives Conformational Changes Necessary to ß-Barrel Formation in a Pore-Forming Toxin. mBio. 2019 07 02; 10(4).
Score: 0.514
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The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin. mBio. 2019 04 23; 10(2).
Score: 0.507
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The Cholesterol-dependent Cytolysin Membrane-binding Interface Discriminates Lipid Environments of Cholesterol to Support ß-Barrel Pore Insertion. J Biol Chem. 2015 Jul 17; 290(29):17733-17744.
Score: 0.387
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The cholesterol-dependent cytolysin signature motif: a critical element in the allosteric pathway that couples membrane binding to pore assembly. PLoS Pathog. 2012; 8(7):e1002787.
Score: 0.317
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Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4341-6.
Score: 0.268
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Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20226-31.
Score: 0.231
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Identification of functional domains of Clostridium septicum alpha toxin. Biochemistry. 2006 Dec 05; 45(48):14347-54.
Score: 0.215
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Cholesterol-dependent cytolysins, a family of versatile pore-forming toxins. Infect Immun. 2005 Oct; 73(10):6199-209.
Score: 0.198
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Molecular basis of listeriolysin O pH dependence. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12537-42.
Score: 0.196
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Vertical collapse of a cytolysin prepore moves its transmembrane beta-hairpins to the membrane. EMBO J. 2004 Aug 18; 23(16):3206-15.
Score: 0.183
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Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria. Nat Commun. 2024 Jun 12; 15(1):5028.
Score: 0.181
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The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin. J Biol Chem. 2004 Apr 02; 279(14):14315-22.
Score: 0.176
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Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):13803-8.
Score: 0.174
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Monomer-monomer interactions drive the prepore to pore conversion of a beta-barrel-forming cholesterol-dependent cytolysin. J Biol Chem. 2002 Mar 29; 277(13):11597-605.
Score: 0.153
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Clostridium perfringens beta toxin and Clostridium septicum alpha toxin: their mechanisms and possible role in pathogenesis. Vet Microbiol. 2001 Sep 03; 82(1):1-9.
Score: 0.149
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Arresting pore formation of a cholesterol-dependent cytolysin by disulfide trapping synchronizes the insertion of the transmembrane beta-sheet from a prepore intermediate. J Biol Chem. 2001 Mar 16; 276(11):8261-8.
Score: 0.142
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Clostridium perfringens beta-toxin forms potential-dependent, cation-selective channels in lipid bilayers. Infect Immun. 2000 Oct; 68(10):5546-51.
Score: 0.140
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The mechanism of pore assembly for a cholesterol-dependent cytolysin: formation of a large prepore complex precedes the insertion of the transmembrane beta-hairpins. Biochemistry. 2000 Aug 22; 39(33):10284-93.
Score: 0.139
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A listeriolysin O subunit vaccine is protective against Listeria monocytogenes. Vaccine. 2020 08 10; 38(36):5803-5813.
Score: 0.138
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The mechanism of membrane insertion for a cholesterol-dependent cytolysin: a novel paradigm for pore-forming toxins. Cell. 1999 Oct 29; 99(3):293-9.
Score: 0.131
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Identification of a membrane-spanning domain of the thiol-activated pore-forming toxin Clostridium perfringens perfringolysin O: an alpha-helical to beta-sheet transition identified by fluorescence spectroscopy. Biochemistry. 1998 Oct 13; 37(41):14563-74.
Score: 0.122
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Clostridium septicum alpha-toxin is proteolytically activated by furin. Infect Immun. 1997 Oct; 65(10):4130-4.
Score: 0.114
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The propeptide of Clostridium septicum alpha toxin functions as an intramolecular chaperone and is a potent inhibitor of alpha toxin-dependent cytolysis. Mol Microbiol. 1997 Aug; 25(3):429-40.
Score: 0.112
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Generation of a membrane-bound, oligomerized pre-pore complex is necessary for pore formation by Clostridium septicum alpha toxin. Mol Microbiol. 1997 Feb; 23(3):551-8.
Score: 0.109
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Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins. Structure. 2016 09 06; 24(9):1488-98.
Score: 0.105
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Perfringolysin O: The Underrated Clostridium perfringens Toxin? Toxins (Basel). 2015 May 14; 7(5):1702-21.
Score: 0.096
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The primary structure of Clostridium septicum alpha-toxin exhibits similarity with that of Aeromonas hydrophila aerolysin. Infect Immun. 1995 Jan; 63(1):340-4.
Score: 0.094
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The Unique Molecular Choreography of Giant Pore Formation by the Cholesterol-Dependent Cytolysins of Gram-Positive Bacteria. Annu Rev Microbiol. 2015; 69:323-40.
Score: 0.094
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Activation and mechanism of Clostridium septicum alpha toxin. Mol Microbiol. 1993 Nov; 10(3):627-34.
Score: 0.087
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Disulfide-bond scanning reveals assembly state and ß-strand tilt angle of the PFO ß-barrel. Nat Chem Biol. 2013 Jun; 9(6):383-9.
Score: 0.083
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Purification and characterization of the lethal toxin (alpha-toxin) of Clostridium septicum. Infect Immun. 1992 Mar; 60(3):784-90.
Score: 0.077
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The pore-forming toxin listeriolysin O mediates a novel entry pathway of L. monocytogenes into human hepatocytes. PLoS Pathog. 2011 Nov; 7(11):e1002356.
Score: 0.076
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Isolation of a tryptic fragment from Clostridium perfringens theta-toxin that contains sites for membrane binding and self-aggregation. J Biol Chem. 1991 Jul 05; 266(19):12449-54.
Score: 0.074
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Evidence that Clostridium perfringens theta-toxin induces colloid-osmotic lysis of erythrocytes. Infect Immun. 1991 Jul; 59(7):2499-501.
Score: 0.074
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Kinetic aspects of the aggregation of Clostridium perfringens theta-toxin on erythrocyte membranes. A fluorescence energy transfer study. J Biol Chem. 1991 Apr 15; 266(11):6936-41.
Score: 0.073
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Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding. Biochemistry. 2009 May 12; 48(18):3977-87.
Score: 0.064
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Pore-forming activity of alpha-toxin is essential for clostridium septicum-mediated myonecrosis. Infect Immun. 2009 Mar; 77(3):943-51.
Score: 0.062
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Cloning and expression in Escherichia coli of the perfringolysin O (theta-toxin) gene from Clostridium perfringens and characterization of the gene product. Infect Immun. 1988 Dec; 56(12):3228-34.
Score: 0.062
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Nucleotide sequence of the gene for perfringolysin O (theta-toxin) from Clostridium perfringens: significant homology with the genes for streptolysin O and pneumolysin. Infect Immun. 1988 Dec; 56(12):3235-40.
Score: 0.062
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Purification and characterization of toxin B from Clostridium difficile. Infect Immun. 1988 Jul; 56(7):1708-14.
Score: 0.060
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Purification of staphylococcal enterotoxins. Methods Enzymol. 1988; 165:43-52.
Score: 0.058
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Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins. J Mol Biol. 2007 Apr 13; 367(5):1227-36.
Score: 0.054
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Cytotoxic activity of Bacillus anthracis protective antigen observed in a macrophage cell line overexpressing ANTXR1. Cell Microbiol. 2006 Aug; 8(8):1272-81.
Score: 0.052
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Helical crystallization on nickel-lipid nanotubes: perfringolysin O as a model protein. J Struct Biol. 2005 Nov; 152(2):129-39.
Score: 0.050
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The domains of a cholesterol-dependent cytolysin undergo a major FRET-detected rearrangement during pore formation. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7139-44.
Score: 0.048
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Prepore to pore transition of a cholesterol-dependent cytolysin visualized by electron microscopy. J Struct Biol. 2005 Apr; 150(1):100-8.
Score: 0.048
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Intracellular glycosylphosphatidylinositols accumulate on endosomes: toxicity of alpha-toxin to Leishmania major. Eukaryot Cell. 2005 Mar; 4(3):556-66.
Score: 0.048
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Transport and processing of staphylococcal alpha-toxin. J Bacteriol. 1983 Nov; 156(2):524-8.
Score: 0.043
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Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin. Nat Struct Biol. 2002 Nov; 9(11):823-7.
Score: 0.040
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Clostridium septicum alpha-toxin is active against the parasitic protozoan Toxoplasma gondii and targets members of the SAG family of glycosylphosphatidylinositol-anchored surface proteins. Infect Immun. 2002 Aug; 70(8):4353-61.
Score: 0.040
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Beta-barrel pore-forming toxins: intriguing dimorphic proteins. Biochemistry. 2001 Aug 07; 40(31):9065-73.
Score: 0.037
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The cholesterol-dependent cytolysins. Curr Top Microbiol Immunol. 2001; 257:15-33.
Score: 0.036
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Mechanism of membrane insertion of a multimeric beta-barrel protein: perfringolysin O creates a pore using ordered and coupled conformational changes. Mol Cell. 2000 Nov; 6(5):1233-42.
Score: 0.035
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Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Streptococcus pneumoniae Infection. J Immunol. 2020 01 01; 204(1):101-111.
Score: 0.033
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Expression and properties of an aerolysin--Clostridium septicum alpha toxin hybrid protein. Mol Microbiol. 1999 Feb; 31(3):785-94.
Score: 0.031
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Clostridial gas gangrene: evidence that alpha and theta toxins differentially modulate the immune response and induce acute tissue necrosis. J Infect Dis. 1997 Jul; 176(1):189-95.
Score: 0.028
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Crystallization and preliminary X-ray analysis of a thiol-activated cytolysin. FEBS Lett. 1996 Nov 18; 397(2-3):290-2.
Score: 0.027
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Effects of Clostridium perfringens recombinant and crude phospholipase C and theta-toxin on rabbit hemodynamic parameters. J Infect Dis. 1995 Nov; 172(5):1317-23.
Score: 0.025
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Efficient gene delivery and expression in mammalian cells using DNA coupled with perfringolysin O. Gene Ther. 1995 Sep; 2(7):498-503.
Score: 0.025
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Structural studies of Streptococcus pyogenes streptolysin O provide insights into the early steps of membrane penetration. J Mol Biol. 2014 Feb 20; 426(4):785-92.
Score: 0.022
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Clostridium perfringens invasiveness is enhanced by effects of theta toxin upon PMNL structure and function: the roles of leukocytotoxicity and expression of CD11/CD18 adherence glycoprotein. FEMS Immunol Med Microbiol. 1993 Dec; 7(4):321-36.
Score: 0.022
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Capacity of listeriolysin O, streptolysin O, and perfringolysin O to mediate growth of Bacillus subtilis within mammalian cells. Infect Immun. 1992 Jul; 60(7):2710-7.
Score: 0.020
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Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit beta-strand alignment. Nat Struct Mol Biol. 2004 Aug; 11(8):697-705.
Score: 0.011
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Assembly and topography of the prepore complex in cholesterol-dependent cytolysins. J Biol Chem. 2003 Aug 15; 278(33):31218-25.
Score: 0.011
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Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors. J Biol Chem. 1999 Sep 17; 274(38):27274-80.
Score: 0.008
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The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae. J Mol Biol. 1998 Nov 27; 284(2):449-61.
Score: 0.008