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Connection

Rodney Tweten to Hemolysin Proteins

This is a "connection" page, showing publications Rodney Tweten has written about Hemolysin Proteins.
Connection Strength

4.486
  1. An Intermolecular p-Stacking Interaction Drives Conformational Changes Necessary to ß-Barrel Formation in a Pore-Forming Toxin. mBio. 2019 07 02; 10(4).
    View in: PubMed
    Score: 0.645
  2. The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin. mBio. 2019 04 23; 10(2).
    View in: PubMed
    Score: 0.637
  3. The Cholesterol-dependent Cytolysin Membrane-binding Interface Discriminates Lipid Environments of Cholesterol to Support ß-Barrel Pore Insertion. J Biol Chem. 2015 Jul 17; 290(29):17733-17744.
    View in: PubMed
    Score: 0.486
  4. The cholesterol-dependent cytolysin signature motif: a critical element in the allosteric pathway that couples membrane binding to pore assembly. PLoS Pathog. 2012; 8(7):e1002787.
    View in: PubMed
    Score: 0.397
  5. Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4341-6.
    View in: PubMed
    Score: 0.336
  6. Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20226-31.
    View in: PubMed
    Score: 0.290
  7. Generation of a membrane-bound, oligomerized pre-pore complex is necessary for pore formation by Clostridium septicum alpha toxin. Mol Microbiol. 1997 Feb; 23(3):551-8.
    View in: PubMed
    Score: 0.136
  8. Perfringolysin O: The Underrated Clostridium perfringens Toxin? Toxins (Basel). 2015 May 14; 7(5):1702-21.
    View in: PubMed
    Score: 0.121
  9. Conformational changes during pore formation by the perforin-related protein pleurotolysin. PLoS Biol. 2015 Feb; 13(2):e1002049.
    View in: PubMed
    Score: 0.119
  10. Activation and mechanism of Clostridium septicum alpha toxin. Mol Microbiol. 1993 Nov; 10(3):627-34.
    View in: PubMed
    Score: 0.109
  11. Disulfide-bond scanning reveals assembly state and ß-strand tilt angle of the PFO ß-barrel. Nat Chem Biol. 2013 Jun; 9(6):383-9.
    View in: PubMed
    Score: 0.105
  12. The pore-forming toxin listeriolysin O mediates a novel entry pathway of L. monocytogenes into human hepatocytes. PLoS Pathog. 2011 Nov; 7(11):e1002356.
    View in: PubMed
    Score: 0.095
  13. Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding. Biochemistry. 2009 May 12; 48(18):3977-87.
    View in: PubMed
    Score: 0.080
  14. Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins. J Mol Biol. 2007 Apr 13; 367(5):1227-36.
    View in: PubMed
    Score: 0.068
  15. Molecular basis of listeriolysin O pH dependence. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12537-42.
    View in: PubMed
    Score: 0.062
  16. Vertical collapse of a cytolysin prepore moves its transmembrane beta-hairpins to the membrane. EMBO J. 2004 Aug 18; 23(16):3206-15.
    View in: PubMed
    Score: 0.057
  17. Transport and processing of staphylococcal alpha-toxin. J Bacteriol. 1983 Nov; 156(2):524-8.
    View in: PubMed
    Score: 0.054
  18. Monomer-monomer interactions drive the prepore to pore conversion of a beta-barrel-forming cholesterol-dependent cytolysin. J Biol Chem. 2002 Mar 29; 277(13):11597-605.
    View in: PubMed
    Score: 0.048
  19. The cholesterol-dependent cytolysins. Curr Top Microbiol Immunol. 2001; 257:15-33.
    View in: PubMed
    Score: 0.045
  20. Arresting pore formation of a cholesterol-dependent cytolysin by disulfide trapping synchronizes the insertion of the transmembrane beta-sheet from a prepore intermediate. J Biol Chem. 2001 Mar 16; 276(11):8261-8.
    View in: PubMed
    Score: 0.044
  21. The mechanism of pore assembly for a cholesterol-dependent cytolysin: formation of a large prepore complex precedes the insertion of the transmembrane beta-hairpins. Biochemistry. 2000 Aug 22; 39(33):10284-93.
    View in: PubMed
    Score: 0.044
  22. A listeriolysin O subunit vaccine is protective against Listeria monocytogenes. Vaccine. 2020 08 10; 38(36):5803-5813.
    View in: PubMed
    Score: 0.043
  23. The mechanism of membrane insertion for a cholesterol-dependent cytolysin: a novel paradigm for pore-forming toxins. Cell. 1999 Oct 29; 99(3):293-9.
    View in: PubMed
    Score: 0.041
  24. Identification of a membrane-spanning domain of the thiol-activated pore-forming toxin Clostridium perfringens perfringolysin O: an alpha-helical to beta-sheet transition identified by fluorescence spectroscopy. Biochemistry. 1998 Oct 13; 37(41):14563-74.
    View in: PubMed
    Score: 0.038
  25. Crystallization and preliminary X-ray analysis of a thiol-activated cytolysin. FEBS Lett. 1996 Nov 18; 397(2-3):290-2.
    View in: PubMed
    Score: 0.034
  26. Effects of Clostridium perfringens recombinant and crude phospholipase C and theta-toxin on rabbit hemodynamic parameters. J Infect Dis. 1995 Nov; 172(5):1317-23.
    View in: PubMed
    Score: 0.031
  27. Efficient gene delivery and expression in mammalian cells using DNA coupled with perfringolysin O. Gene Ther. 1995 Sep; 2(7):498-503.
    View in: PubMed
    Score: 0.031
  28. Structural studies of Streptococcus pyogenes streptolysin O provide insights into the early steps of membrane penetration. J Mol Biol. 2014 Feb 20; 426(4):785-92.
    View in: PubMed
    Score: 0.027
  29. Clostridium perfringens invasiveness is enhanced by effects of theta toxin upon PMNL structure and function: the roles of leukocytotoxicity and expression of CD11/CD18 adherence glycoprotein. FEMS Immunol Med Microbiol. 1993 Dec; 7(4):321-36.
    View in: PubMed
    Score: 0.027
  30. Capacity of listeriolysin O, streptolysin O, and perfringolysin O to mediate growth of Bacillus subtilis within mammalian cells. Infect Immun. 1992 Jul; 60(7):2710-7.
    View in: PubMed
    Score: 0.025
  31. Evidence that Clostridium perfringens theta-toxin induces colloid-osmotic lysis of erythrocytes. Infect Immun. 1991 Jul; 59(7):2499-501.
    View in: PubMed
    Score: 0.023
  32. Kinetic aspects of the aggregation of Clostridium perfringens theta-toxin on erythrocyte membranes. A fluorescence energy transfer study. J Biol Chem. 1991 Apr 15; 266(11):6936-41.
    View in: PubMed
    Score: 0.023
  33. Cloning and expression in Escherichia coli of the perfringolysin O (theta-toxin) gene from Clostridium perfringens and characterization of the gene product. Infect Immun. 1988 Dec; 56(12):3228-34.
    View in: PubMed
    Score: 0.019
  34. Nucleotide sequence of the gene for perfringolysin O (theta-toxin) from Clostridium perfringens: significant homology with the genes for streptolysin O and pneumolysin. Infect Immun. 1988 Dec; 56(12):3235-40.
    View in: PubMed
    Score: 0.019
  35. Helical crystallization on nickel-lipid nanotubes: perfringolysin O as a model protein. J Struct Biol. 2005 Nov; 152(2):129-39.
    View in: PubMed
    Score: 0.016
  36. The domains of a cholesterol-dependent cytolysin undergo a major FRET-detected rearrangement during pore formation. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7139-44.
    View in: PubMed
    Score: 0.015
  37. Prepore to pore transition of a cholesterol-dependent cytolysin visualized by electron microscopy. J Struct Biol. 2005 Apr; 150(1):100-8.
    View in: PubMed
    Score: 0.015
  38. Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit beta-strand alignment. Nat Struct Mol Biol. 2004 Aug; 11(8):697-705.
    View in: PubMed
    Score: 0.014
  39. Assembly and topography of the prepore complex in cholesterol-dependent cytolysins. J Biol Chem. 2003 Aug 15; 278(33):31218-25.
    View in: PubMed
    Score: 0.013
  40. Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin. Nat Struct Biol. 2002 Nov; 9(11):823-7.
    View in: PubMed
    Score: 0.013
  41. Mechanism of membrane insertion of a multimeric beta-barrel protein: perfringolysin O creates a pore using ordered and coupled conformational changes. Mol Cell. 2000 Nov; 6(5):1233-42.
    View in: PubMed
    Score: 0.011
  42. Expression and properties of an aerolysin--Clostridium septicum alpha toxin hybrid protein. Mol Microbiol. 1999 Feb; 31(3):785-94.
    View in: PubMed
    Score: 0.010
  43. The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae. J Mol Biol. 1998 Nov 27; 284(2):449-61.
    View in: PubMed
    Score: 0.010
  44. Clostridial gas gangrene: evidence that alpha and theta toxins differentially modulate the immune response and induce acute tissue necrosis. J Infect Dis. 1997 Jul; 176(1):189-95.
    View in: PubMed
    Score: 0.009
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.