Doris Benbrook to Humans
This is a "connection" page, showing publications Doris Benbrook has written about Humans.
Connection Strength
1.286
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Targeting HSP70-E7 Interaction With SHetA2: A Novel Therapeutic Strategy for Cervical Cancer. J Med Virol. 2024 Nov; 96(11):e70088.
Score: 0.055
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Platelet and epithelial cell interations can be modeled in cell culture, and are not affected by dihomo-gamma-linolenic acid. PLoS One. 2024; 19(8):e0309125.
Score: 0.054
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Association of Sialyl Tn antigen with cervical cancer lymph node status: An NRG oncology/GOG study. Gynecol Oncol. 2023 04; 171:67-75.
Score: 0.049
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Identification of Candidate Biomarker and Drug Targets for Improving Endometrial Cancer Racial Disparities. Int J Mol Sci. 2022 Jul 14; 23(14).
Score: 0.047
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Sera Protein Signatures of Endometrial Cancer Lymph Node Metastases. Int J Mol Sci. 2022 Mar 18; 23(6).
Score: 0.046
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Similarities and Differences of Hsp70, hsc70, Grp78 and Mortalin as Cancer Biomarkers and Drug Targets. Cells. 2021 11 03; 10(11).
Score: 0.045
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Novel ovarian cancer maintenance therapy targeted at mortalin and mutant p53. Int J Cancer. 2020 08 15; 147(4):1086-1097.
Score: 0.039
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Tetrahydroquinoline units in flexible heteroarotinoids (Flex-Hets) convey anti-cancer properties in A2780 ovarian cancer cells. Bioorg Med Chem. 2020 01 01; 28(1):115244.
Score: 0.039
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Accelerated vascular aging and persistent cognitive impairment in older female breast cancer survivors. Geroscience. 2018 06; 40(3):325-336.
Score: 0.035
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Correlation of clinical data with fallopian tube specimen immune cells and tissue culture capacity. Tissue Cell. 2018 Jun; 52:57-64.
Score: 0.035
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The pro-inflammatory effect of obesity on high grade serous ovarian cancer. Gynecol Oncol. 2016 10; 143(1):40-45.
Score: 0.031
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Insulin exerts direct effects on carcinogenic transformation of human endometrial organotypic cultures. Cancer Invest. 2014 Mar; 32(3):63-70.
Score: 0.026
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History of retinoic acid receptors. Subcell Biochem. 2014; 70:1-20.
Score: 0.026
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SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheres. Invest New Drugs. 2014 Jun; 32(3):412-23.
Score: 0.026
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Integration of autophagy, proteasomal degradation, unfolded protein response and apoptosis. Exp Oncol. 2012 Oct; 34(3):286-97.
Score: 0.024
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A phase II trial of thalidomide in patients with refractory uterine carcinosarcoma and correlation with biomarkers of angiogenesis: a Gynecologic Oncology Group study. Gynecol Oncol. 2012 Nov; 127(2):356-61.
Score: 0.023
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The pro-survival function of Akt kinase can be overridden or altered to contribute to induction of apoptosis. Curr Cancer Drug Targets. 2011 Jun; 11(5):586-99.
Score: 0.022
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Randomized phase III trial of tamoxifen versus thalidomide in women with biochemical-recurrent-only epithelial ovarian, fallopian tube or primary peritoneal carcinoma after a complete response to first-line platinum/taxane chemotherapy with an evaluation of serum vascular endothelial growth factor (VEGF): A Gynecologic Oncology Group Study. Gynecol Oncol. 2010 Dec; 119(3):444-50.
Score: 0.021
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NF-kappaB is involved in SHetA2 circumvention of TNF-alpha resistance, but not induction of intrinsic apoptosis. Anticancer Drugs. 2010 Mar; 21(3):297-305.
Score: 0.020
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Induction of death receptor ligand-mediated apoptosis in epithelial ovarian carcinoma: The search for sensitizing agents. Gynecol Oncol. 2009 Dec; 115(3):438-42.
Score: 0.019
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Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells. Cancer Res. 2009 Aug 15; 69(16):6565-72.
Score: 0.019
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Development of flexible-heteroarotinoids for kidney cancer. Mol Cancer Ther. 2009 May; 8(5):1227-38.
Score: 0.019
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Flexible heteroarotinoid (Flex-Het) SHetA2 inhibits angiogenesis in vitro and in vivo. Invest New Drugs. 2009 Aug; 27(4):304-18.
Score: 0.018
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A phase II trial of thalidomide in patients with refractory leiomyosarcoma of the uterus and correlation with biomarkers of angiogenesis: a gynecologic oncology group study. Gynecol Oncol. 2007 Sep; 106(3):596-603.
Score: 0.017
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Flex-Hets differentially induce apoptosis in cancer over normal cells by directly targeting mitochondria. Mol Cancer Ther. 2007 Jun; 6(6):1814-22.
Score: 0.016
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Promise and problems of translational research. Gynecol Oncol. 2006 Nov; 103(2 Suppl 1):S14-7.
Score: 0.016
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Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists. Invest New Drugs. 2005 Oct; 23(5):417-28.
Score: 0.015
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Sensitization of cervical cancer cell lines to low-dose radiation by retinoic acid does not require functional p53. Gynecol Oncol. 2005 Apr; 97(1):142-50.
Score: 0.014
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Synthesis of flexible sulfur-containing heteroarotinoids that induce apoptosis and reactive oxygen species with discrimination between malignant and benign cells. J Med Chem. 2004 Feb 12; 47(4):999-1007.
Score: 0.013
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Pharmacodynamics of Cyclin D1 Degradation in Ovarian Cancer Xenografts with Repeated Oral SHetA2 Dosing. AAPS J. 2023 Dec 12; 26(1):5.
Score: 0.013
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Niclosamide causes lysosome-dependent cell death in endometrial cancer cells and tumors. Biomed Pharmacother. 2023 May; 161:114422.
Score: 0.012
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Association between Serum Biomarkers with Postoperative Complications and Delay of Adjuvant Chemotherapy Initiation in Ovarian Cancer Patients Undergoing Primary Cytoreductive Surgery: A Pilot Study. Nutr Cancer. 2023; 75(2):662-669.
Score: 0.012
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Retinoids and steroids regulate menstrual phase histological features in human endometrial organotypic cultures. Fertil Steril. 2002 Sep; 78(3):596-602.
Score: 0.012
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Refining retinoids with heteroatoms. Mini Rev Med Chem. 2002 Jun; 2(3):277-83.
Score: 0.012
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An ELISA method for detection of human antibodies to an immunotoxin. J Pharmacol Toxicol Methods. 2002 May-Jun; 47(3):169-75.
Score: 0.012
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Retinoids enhance cisplatin-based chemoradiation in cervical cancer cells in vitro. Gynecol Oncol. 2002 Apr; 85(1):223-5.
Score: 0.012
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Heterocycle-containing retinoids. Discovery of a novel isoxazole arotinoid possessing potent apoptotic activity in multidrug and drug-induced apoptosis-resistant cells. J Med Chem. 2001 Jul 05; 44(14):2308-18.
Score: 0.011
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Effects of retinoids on cancerous phenotype and apoptosis in organotypic cultures of ovarian carcinoma. J Natl Cancer Inst. 2001 Apr 04; 93(7):516-25.
Score: 0.011
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382.
Score: 0.011
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Potential and mechanism of mebendazole for treatment and maintenance of ovarian cancer. Gynecol Oncol. 2021 01; 160(1):302-311.
Score: 0.010
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Vaginal Suppositories Containing SHetA2 to Treat Cervical Dysplasia: Pharmacokinetics of Daily Doses and Preliminary Safety Profile. J Pharm Sci. 2020 06; 109(6):2000-2008.
Score: 0.010
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Physiologically Based Pharmacokinetic Modeling and Tissue Distribution Characteristics of SHetA2 in Tumor-Bearing Mice. AAPS J. 2020 02 21; 22(2):51.
Score: 0.010
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Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors. J Med Chem. 1999 Oct 21; 42(21):4434-45.
Score: 0.010
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Synthesis, structure-activity relationships, and RARgamma-ligand interactions of nitrogen heteroarotinoids. J Med Chem. 1999 Sep 09; 42(18):3602-14.
Score: 0.010
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The mechanism of retinoic acid radiosensitization is independent of AP-1 repression in a cervical carcinoma cell line. Gynecol Oncol. 1999 May; 73(2):253-6.
Score: 0.009
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Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research. Geroscience. 2019 04; 41(2):209-227.
Score: 0.009
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Synthesis and biological evaluation of SHetA2 (NSC-721689) analogs against the ovarian cancer cell line A2780. Eur J Med Chem. 2019 May 15; 170:16-27.
Score: 0.009
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Activity of oxygen-versus sulfur-containing analogs of the Flex-Het anticancer agent SHetA2. Eur J Med Chem. 2018 Oct 05; 158:720-732.
Score: 0.009
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Anti-CD73 and anti-OX40 immunotherapy coupled with a novel biocompatible enzyme prodrug system for the treatment of recurrent, metastatic ovarian cancer. Cancer Lett. 2018 07 01; 425:174-182.
Score: 0.009
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Biologically active heteroarotinoids exhibiting anticancer activity and decreased toxicity. J Med Chem. 1997 Oct 24; 40(22):3567-83.
Score: 0.008
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Optimization of a Vaginal Suppository Formulation to Deliver SHetA2 as a Novel Treatment for Cervical Dysplasia. J Pharm Sci. 2018 02; 107(2):638-646.
Score: 0.008
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Biological assay for activity and molecular mechanism of retinoids in cervical tumor cells. Gynecol Oncol. 1997 Jul; 66(1):114-21.
Score: 0.008
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Epidermal growth factor receptor in vulvar malignancies and its relationship to metastasis and patient survival. Gynecol Oncol. 1997 Jun; 65(3):425-9.
Score: 0.008
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Differential retinoic acid radiosensitization of cervical carcinoma cell lines. Clin Cancer Res. 1997 Jun; 3(6):939-45.
Score: 0.008
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Loss of natural killer T cells promotes pancreatic cancer in LSL-KrasG12D/+ mice. Immunology. 2017 09; 152(1):36-51.
Score: 0.008
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A stratified randomized double-blind phase II trial of celecoxib for treating patients with cervical intraepithelial neoplasia: The potential predictive value of VEGF serum levels: An NRG Oncology/Gynecologic Oncology Group study. Gynecol Oncol. 2017 05; 145(2):291-297.
Score: 0.008
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Silencing BMI1 radiosensitizes human breast cancer cells by inducing DNA damage and autophagy. Oncol Rep. 2017 Apr; 37(4):2382-2390.
Score: 0.008
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Label-Free Real-Time Microarray Imaging of Cancer Protein-Protein Interactions and Their Inhibition by Small Molecules. Anal Chem. 2016 Mar 15; 88(6):3130-5.
Score: 0.008
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Aberrant NRP-1 expression serves as predicator of metastatic endometrial and lung cancers. Oncotarget. 2016 Feb 16; 7(7):7970-8.
Score: 0.008
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Therapeutic options for management of endometrial hyperplasia. J Gynecol Oncol. 2016 Jan; 27(1):e8.
Score: 0.007
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Immunohistochemical analysis of proliferation and differentiation in organotypic cultures of cervical tumor cell lines. Tissue Cell. 1995 Jun; 27(3):269-74.
Score: 0.007
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Synthesis and evaluation of second generation Flex-Het scaffolds against the human ovarian cancer A2780 cell line. Eur J Med Chem. 2015; 96:209-17.
Score: 0.007
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A phase II trial of brivanib in recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study. Gynecol Oncol. 2014 Oct; 135(1):38-43.
Score: 0.007
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Different binding specificities and transactivation of variant CRE's by CREB complexes. Nucleic Acids Res. 1994 Apr 25; 22(8):1463-9.
Score: 0.007
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Measurements of adiposity as clinical biomarkers for first-line bevacizumab-based chemotherapy in epithelial ovarian cancer. Gynecol Oncol. 2014 Apr; 133(1):11-5.
Score: 0.007
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The role of single nucleotide polymorphisms of the ERCC1 and MMS19 genes in predicting platinum-sensitivity, progression-free and overall survival in advanced epithelial ovarian cancer. Gynecol Oncol. 2013 Aug; 130(2):377-82.
Score: 0.006
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Genotoxicity of the cancer chemopreventive drug candidates CP-31398, SHetA2, and phospho-ibuprofen. Mutat Res. 2012 Jul 04; 746(1):78-88.
Score: 0.006
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Wnt inhibitory factor 1 induces apoptosis and inhibits cervical cancer growth, invasion and angiogenesis in vivo. Oncogene. 2012 May 31; 31(22):2725-37.
Score: 0.006
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Clioquinol suppresses cyclin D1 gene expression through transcriptional and post-transcriptional mechanisms. Anticancer Res. 2011 Sep; 31(9):2739-47.
Score: 0.006
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Nitroxoline (8-hydroxy-5-nitroquinoline) is more a potent anti-cancer agent than clioquinol (5-chloro-7-iodo-8-quinoline). Cancer Lett. 2011 Dec 15; 312(1):11-7.
Score: 0.005
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Internal standard-based analysis of microarray data2--analysis of functional associations between HVE-genes. Nucleic Acids Res. 2011 Oct; 39(18):7881-99.
Score: 0.005
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A Gynecologic Oncology Group phase II trial of the protein kinase C-beta inhibitor, enzastaurin and evaluation of markers with potential predictive and prognostic value in persistent or recurrent epithelial ovarian and primary peritoneal malignancies. Gynecol Oncol. 2011 Jun 01; 121(3):455-61.
Score: 0.005
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N-Acetylcysteine interacts with copper to generate hydrogen peroxide and selectively induce cancer cell death. Cancer Lett. 2010 Dec 08; 298(2):186-94.
Score: 0.005
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Heterodimer formation between CREB and JUN proteins. Oncogene. 1990 Mar; 5(3):295-302.
Score: 0.005
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Selective growth inhibition of cancer cells by L-methioninase-containing fusion protein targeted to the urokinase receptor. Pharmacology. 2009; 84(5):271-5.
Score: 0.005
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Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling. Mol Pharmacol. 2009 Sep; 76(3):588-95.
Score: 0.005
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PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexaenoic acid in human cancer cells. Biochem Pharmacol. 2009 May 01; 77(9):1480-6.
Score: 0.005
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Metabolism of a sulfur-containing heteroarotionoid antitumor agent, SHetA2, using liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2008 Nov; 22(21):3371-81.
Score: 0.005
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Involvement of c-FLIP and survivin down-regulation in flexible heteroarotinoid-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells. Mol Cancer Ther. 2008 Nov; 7(11):3556-65.
Score: 0.005
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CAAT/enhancer binding protein homologous protein-dependent death receptor 5 induction is a major component of SHetA2-induced apoptosis in lung cancer cells. Cancer Res. 2008 Jul 01; 68(13):5335-44.
Score: 0.004
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A new retinoic acid receptor identified from a hepatocellular carcinoma. Nature. 1988 Jun 16; 333(6174):669-72.
Score: 0.004
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Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc. Cancer Res. 2008 Mar 15; 68(6):1636-46.
Score: 0.004
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Nucleotide sequence of cDNA encoding a novel human thyroid hormone receptor. Nucleic Acids Res. 1987 Nov 25; 15(22):9613.
Score: 0.004
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A novel thyroid hormone receptor encoded by a cDNA clone from a human testis library. Science. 1987 Nov 06; 238(4828):788-91.
Score: 0.004
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A phase II trial of thalidomide in patients with refractory endometrial cancer and correlation with angiogenesis biomarkers: a Gynecologic Oncology Group study. Gynecol Oncol. 2007 May; 105(2):508-16.
Score: 0.004
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Nonphotochemical hole-burning study of selectively stained normal and cancerous human ovarian tissues. J Phys Chem B. 2006 Aug 17; 110(32):16124-30.
Score: 0.004
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High performance liquid chromatographic analysis and preclinical pharmacokinetics of the heteroarotinoid antitumor agent, SHetA2. Cancer Chemother Pharmacol. 2006 Nov; 58(5):561-9.
Score: 0.004
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Effect of all-trans retinoic acid on tissue dynamics of choriocarcinoma cell lines: an organotypic model. J Clin Pathol. 2006 Aug; 59(8):845-50.
Score: 0.004
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The synthetic heteroarotinoid SHetA2 induces apoptosis in squamous carcinoma cells through a receptor-independent and mitochondria-dependent pathway. Cancer Res. 2003 Jul 01; 63(13):3826-32.
Score: 0.003
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Antitumor activity of SS(dsFv)PE38 and SS1(dsFv)PE38, recombinant antimesothelin immunotoxins against human gynecologic cancers grown in organotypic culture in vitro. Clin Cancer Res. 2002 Nov; 8(11):3520-6.
Score: 0.003
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Retinoid signaling in immortalized and carcinoma-derived human uroepithelial cells. Mol Cell Endocrinol. 1999 Feb 25; 148(1-2):55-65.
Score: 0.002
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Complexity, retinoid-responsive gene networks, and bladder carcinogenesis. Adv Exp Med Biol. 1999; 462:449-67.
Score: 0.002
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The role of human papillomavirus in the development of pyogenic granulomas. Int J Dermatol. 1997 Sep; 36(9):673-6.
Score: 0.002