Michael Ihnat to Mice
This is a "connection" page, showing publications Michael Ihnat has written about Mice.
Connection Strength
0.704
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AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1a stabilization. Cancer Lett. 2017 03 01; 388:149-157.
Score: 0.071
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A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer. J Pharmacol Exp Ther. 2015 May; 353(2):392-404.
Score: 0.063
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Development and characterization of a preclinical model of breast cancer lung micrometastatic to macrometastatic progression. PLoS One. 2014; 9(5):e98624.
Score: 0.060
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Suppression and activation of the malignant phenotype by extracellular matrix in xenograft models of bladder cancer: a model for tumor cell "dormancy". PLoS One. 2013; 8(5):e64181.
Score: 0.056
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N4-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation. Bioorg Med Chem. 2012 Apr 01; 20(7):2444-54.
Score: 0.051
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Role of HIF signaling on tumorigenesis in response to chronic low-dose arsenic administration. Toxicol Sci. 2005 Aug; 86(2):248-57.
Score: 0.032
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Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents. Bioorg Med Chem Lett. 2021 06 01; 41:127923.
Score: 0.024
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The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity. Bioorg Med Chem. 2021 01 01; 29:115887.
Score: 0.023
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Effects of mitomycin C and carboplatin pretreatment on multidrug resistance-associated P-glycoprotein expression and on subsequent suppression of tumor growth by doxorubicin and paclitaxel in human metastatic breast cancer xenografted nude mice. Oncol Res. 1999; 11(7):303-10.
Score: 0.021
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Design, synthesis and preclinical evaluation of 5-methyl-N4-aryl-furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential. Bioorg Med Chem Lett. 2018 10 01; 28(18):3085-3093.
Score: 0.020
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Interleukin (IL)-6 modulates transforming growth factor-ß receptor I and II (TGF-ßRI and II) function in epidermal keratinocytes. Exp Dermatol. 2017 08; 26(8):697-704.
Score: 0.018
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Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. Bioorg Med Chem Lett. 2017 04 01; 27(7):1602-1607.
Score: 0.018
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A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model. BMC Cancer. 2015 Jul 17; 15:522.
Score: 0.016
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The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents. Bioorg Med Chem. 2014 Jul 15; 22(14):3753-72.
Score: 0.015
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Evaluation of 99mTc-probestin for imaging APN expressing tumors by SPECT. Bioorg Med Chem Lett. 2013 Sep 15; 23(18):5049-52.
Score: 0.014
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N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents. Bioorg Med Chem. 2013 Mar 01; 21(5):1312-23.
Score: 0.014
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Synthesis and biodistribution studies of technetium-99m-labeled aminopeptidase N inhibitor conjugates. Bioorg Med Chem Lett. 2012 Jul 15; 22(14):4567-70.
Score: 0.013
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Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents. Bioorg Med Chem. 2012 Jul 15; 20(14):4217-25.
Score: 0.013
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SOCS3 modulates interleukin-6R signaling preference in dermal fibroblasts. J Interferon Cytokine Res. 2012 May; 32(5):207-15.
Score: 0.013
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Synthesis and evaluation of novel Tc-99m labeled probestin conjugates for imaging APN/CD13 expression in vivo. Bioconjug Chem. 2012 Jan 18; 23(1):115-24.
Score: 0.013
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A PEDF-derived peptide inhibits retinal neovascularization and blocks mobilization of bone marrow-derived endothelial progenitor cells. Exp Diabetes Res. 2012; 2012:518426.
Score: 0.012
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Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents. Bioorg Med Chem. 2010 May 15; 18(10):3575-87.
Score: 0.011
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Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res. 2010 Mar 15; 70(6):2445-54.
Score: 0.011
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Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. J Med Chem. 2010 Feb 25; 53(4):1563-78.
Score: 0.011
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Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors. Bioorg Med Chem. 2009 Oct 15; 17(20):7324-36.
Score: 0.011
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Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung. Environ Health Perspect. 2009 Jul; 117(7):1108-15.
Score: 0.010
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Laboratory diet profoundly alters gene expression and confounds genomic analysis in mouse liver and lung. Chem Biol Interact. 2008 May 28; 173(2):129-40.
Score: 0.010
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Repeated BCG treatment of mouse bladder selectively stimulates small GTPases and HLA antigens and inhibits single-spanning uroplakins. BMC Cancer. 2007 Nov 02; 7:204.
Score: 0.009
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Transcription factor network downstream of protease activated receptors (PARs) modulating mouse bladder inflammation. BMC Immunol. 2007 Aug 17; 8:17.
Score: 0.009
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Exposure to arsenic at levels found inU.S. drinking water modifies expression in the mouse lung. Toxicol Sci. 2007 Nov; 100(1):75-87.
Score: 0.009
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Regulatory network of inflammation downstream of proteinase-activated receptors. BMC Physiol. 2007 Mar 30; 7:3.
Score: 0.009
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Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation. BMC Physiol. 2007 Mar 30; 7:4.
Score: 0.009
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Novel 5-substituted, 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity. Bioorg Med Chem. 2005 Sep 15; 13(18):5475-91.
Score: 0.008
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Arsenic stimulates angiogenesis and tumorigenesis in vivo. Toxicol Sci. 2003 Dec; 76(2):271-9.
Score: 0.007