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Hui-Ying Lim

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPhysiology
AddressBSEB 330A
941 Stanton L Young Blvd
Oklahoma City OK 73104
Phone405/271-2226
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    Collapse Research 
    Collapse research activities and funding
    R01HL152205     (LIM, HUI-YING)Apr 1, 2020 - Mar 31, 2025
    NIH
    A cardiac Wingless-Snail-Tep2 axis directs normal lipid homeostasis and protects against diet-induced obesity
    Role: Principal Investigator
    R01HL128455     (LIM, HUI-YING)Jul 1, 2014 - Jun 30, 2021
    NIH
    ROS signaling, intercellular communication and heart development and function
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Eeda V, Rawal KN, Matlock HG, Herlea-Pana O, Lim HY, Wang W. Hydroxybenzamide derivatives protect pancreatic ß cell by suppressing unfolded protein response activation. Chem Biol Drug Des. 2022 08; 100(2):155-168. PMID: 35615997.
      Citations:    Fields:    Translation:HumansCells
    2. Li Y, Wang W, Lim HY. Drosophila Solute Carrier 5A5 Regulates Systemic Glucose Homeostasis by Mediating Glucose Absorption in the Midgut. Int J Mol Sci. 2021 Nov 17; 22(22). PMID: 34830305.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Herlea-Pana O, Eeda V, Undi RB, Lim HY, Wang W. Pharmacological Inhibition of Inositol-Requiring Enzyme 1a RNase Activity Protects Pancreatic Beta Cell and Improves Diabetic Condition in Insulin Mutation-Induced Diabetes. Front Endocrinol (Lausanne). 2021; 12:749879. PMID: 34675883.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Lim HY, Wang W, Nakagawa Y, Pierzchala-Koziec K. Editorial: The Endocrine Regulation of Systemic Energy Homeostasis Under Physiological and Pathological Conditions. Front Physiol. 2020; 11:602942. PMID: 33192620.
      Citations:    
    5. Eeda V, Herlea-Pana O, Lim HY, Wang W. Discovery of N-(2-(Benzylamino)-2-oxoethyl)benzamide analogs as a novel scaffold of pancreatic ß-cell protective agents against endoplasmic reticulum stress. Chem Biol Drug Des. 2020 03; 95(3):388-393. PMID: 31755655.
      Citations: 1     Fields:    Translation:HumansCells
    6. Liu Y, Bao H, Wang W, Lim HY. Cardiac Snail family of transcription factors directs systemic lipid metabolism in Drosophila. PLoS Genet. 2019 11; 15(11):e1008487. PMID: 31725726.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    7. Eeda V, Wu D, Lim HY, Wang W. Design, synthesis, and evaluation of potent novel peroxisome proliferator-activated receptor ? indole partial agonists. Bioorg Med Chem Lett. 2019 11 15; 29(22):126664. PMID: 31591015.
      Citations: 3     Fields:    Translation:Cells
    8. Lim HY, Bao H, Liu Y, Wang W. Select Septate Junction Proteins Direct ROS-Mediated Paracrine Regulation of Drosophila Cardiac Function. Cell Rep. 2019 08 06; 28(6):1455-1470.e4. PMID: 31390561.
      Citations: 5     Fields:    Translation:AnimalsCells
    9. Duan H, Li Y, Arora D, Xu D, Lim HY, Wang W. Discovery of a Benzamide Derivative That Protects Pancreatic ß-Cells against Endoplasmic Reticulum Stress. J Med Chem. 2017 07 27; 60(14):6191-6204. PMID: 28696115.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    10. Lee S, Bao H, Ishikawa Z, Wang W, Lim HY. Cardiomyocyte Regulation of Systemic Lipid Metabolism by the Apolipoprotein B-Containing Lipoproteins in Drosophila. PLoS Genet. 2017 01; 13(1):e1006555. PMID: 28095410.
      Citations: 15     Fields:    Translation:AnimalsCells
    11. Duan H, Lee JW, Moon SW, Arora D, Li Y, Lim HY, Wang W. Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic ß-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress. J Med Chem. 2016 09 08; 59(17):7783-800. PMID: 27505441.
      Citations: 6     Fields:    Translation:HumansCells
    12. Ang MJ, Lim HA, Poulsen A, Wee JL, Ng FM, Joy J, Hill J, Chia CS. Miniature bovine pancreatic trypsin inhibitors (m-BPTIs) of the West Nile virus NS2B-NS3 protease. J Enzyme Inhib Med Chem. 2016; 31(sup2):194-200. PMID: 27241372.
      Citations: 1     Fields:    Translation:AnimalsCells
    13. Duan H, Arora D, Li Y, Setiadi H, Xu D, Lim HY, Wang W. Identification of 1,2,3-triazole derivatives that protect pancreatic ß cells against endoplasmic reticulum stress-mediated dysfunction and death through the inhibition of C/EBP-homologous protein expression. Bioorg Med Chem. 2016 06 15; 24(12):2621-30. PMID: 27157393.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    14. Griffin TM, Humphries KM, Kinter M, Lim HY, Szweda LI. Nutrient sensing and utilization: Getting to the heart of metabolic flexibility. Biochimie. 2016 May; 124:74-83. PMID: 26476002.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    15. Duan H, Li Y, Lim HY, Wang W. Identification of 5-nitrofuran-2-amide derivatives that induce apoptosis in triple negative breast cancer cells by activating C/EBP-homologous protein expression. Bioorg Med Chem. 2015 Aug 01; 23(15):4514-4521. PMID: 26116180.
      Citations: 3     Fields:    Translation:HumansCells
    16. Chu JJ, Lee RC, Ang MJ, Wang WL, Lim HA, Wee JL, Joy J, Hill J, Brian Chia CS. Antiviral activities of 15 dengue NS2B-NS3 protease inhibitors using a human cell-based viral quantification assay. Antiviral Res. 2015 Jun; 118:68-74. PMID: 25823617.
      Citations: 13     Fields:    Translation:HumansCells
    17. Tran K, Li Y, Duan H, Arora D, Lim HY, Wang W. Identification of small molecules that protect pancreatic ß cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol. 2014 Dec 19; 9(12):2796-806. PMID: 25279668.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    18. Lim HY, Wang W, Chen J, Ocorr K, Bodmer R. ROS regulate cardiac function via a distinct paracrine mechanism. Cell Rep. 2014 Apr 10; 7(1):35-44. PMID: 24656823.
      Citations: 28     Fields:    Translation:AnimalsCells
    19. Lim HA, Ang MJ, Joy J, Poulsen A, Wu W, Ching SC, Hill J, Chia CS. Novel agmatine dipeptide inhibitors against the West Nile virus NS2B/NS3 protease: a P3 and N-cap optimization study. Eur J Med Chem. 2013 Apr; 62:199-205. PMID: 23353753.
      Citations: 8     Fields:    Translation:Cells
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