Paul Cook to Deuterium
This is a "connection" page, showing publications Paul Cook has written about Deuterium.
Connection Strength
1.807
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A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2007 Jan 23; 46(3):871-82.
Score: 0.280
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Multiple isotope effects as a probe of proton and hydride transfer in the 6-phosphogluconate dehydrogenase reaction. Biochemistry. 1998 Nov 10; 37(45):15698-702.
Score: 0.159
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Secondary tritium and solvent deuterium isotope effects as a probe of the reaction catalyzed by porcine recombinant dihydropyrimidine dehydrogenase. Biochemistry. 1998 Jun 23; 37(25):9156-9.
Score: 0.155
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Product dependence of deuterium isotope effects in enzyme-catalyzed reactions. Biochemistry. 1993 Feb 23; 32(7):1795-802.
Score: 0.107
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Site-directed mutagenesis as a probe of the acid-base catalytic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2009 Aug 04; 48(30):7305-12.
Score: 0.084
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Roles of histidines 154 and 189 and aspartate 139 in the active site of serine acetyltransferase from Haemophilus influenzae. Biochemistry. 2008 Jun 17; 47(24):6322-8.
Score: 0.077
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Control of ionizable residues in the catalytic mechanism of tryptophan synthase from Salmonella typhimurium. Biochemistry. 2007 Nov 13; 46(45):13223-34.
Score: 0.074
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Reaction of serine-glyoxylate aminotransferase with the alternative substrate ketomalonate indicates rate-limiting protonation of a quinonoid intermediate. Biochemistry. 2005 Dec 06; 44(48):15930-6.
Score: 0.065
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Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction. Biochemistry. 2003 Jan 14; 42(1):106-13.
Score: 0.053
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Tartrate dehydrogenase catalyzes the stepwise oxidative decarboxylation of D-malate with both NAD and thio-NAD. Biochemistry. 2002 Oct 08; 41(40):12193-9.
Score: 0.052
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Alternative substrates for malic enzyme: oxidative decarboxylation of L-aspartate. Biochemistry. 2002 Oct 08; 41(40):12200-3.
Score: 0.052
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Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions. Biochemistry. 1980 Oct 14; 19(21):4853-8.
Score: 0.045
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Expression and stereochemical and isotope effect studies of active 4-oxalocrotonate decarboxylase. Biochemistry. 2000 Feb 01; 39(4):718-26.
Score: 0.043
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Lysine 183 is the general base in the 6-phosphogluconate dehydrogenase-catalyzed reaction. Biochemistry. 1999 Aug 31; 38(35):11231-8.
Score: 0.042
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Alpha-secondary tritium kinetic isotope effects indicate hydrogen tunneling and coupled motion occur in the oxidation of L-malate by NAD-malic enzyme. Biochemistry. 1999 Apr 06; 38(14):4398-402.
Score: 0.041
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Oxidative decarboxylation of 6-phosphogluconate by 6-phosphogluconate dehydrogenase proceeds by a stepwise mechanism with NADP and APADP as oxidants. Biochemistry. 1998 Sep 08; 37(36):12596-602.
Score: 0.039
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Cysteine 42 is important for maintaining an integral active site for O-acetylserine sulfhydrylase resulting in the stabilization of the alpha-aminoacrylate intermediate. Biochemistry. 1998 Jul 28; 37(30):10597-604.
Score: 0.039
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Kinetic and chemical mechanisms of the sheep liver 6-phosphogluconate dehydrogenase. Arch Biochem Biophys. 1996 Dec 15; 336(2):215-23.
Score: 0.035
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Role of the divalent metal ion in the NAD:malic enzyme reaction: an ESEEM determination of the ground state conformation of malate in the E:Mn:malate complex. Protein Sci. 1996 Aug; 5(8):1648-54.
Score: 0.034
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Kinetic isotope effects as a probe of the beta-elimination reaction catalyzed by O-acetylserine sulfhydrylase. Biochemistry. 1996 May 21; 35(20):6358-65.
Score: 0.033
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Metal ion activator effects on intrinsic isotope effects for hydride transfer from decarboxylation in the reaction catalyzed by the NAD-malic enzyme from Ascaris suum. Biochemistry. 1995 Mar 14; 34(10):3253-60.
Score: 0.031
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Acid-base catalytic mechanism of dihydropyrimidinase from pH studies. Biochemistry. 1993 May 18; 32(19):5160-6.
Score: 0.027
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Acid base catalytic mechanism of the dihydropyrimidine dehydrogenase from pH studies. J Biol Chem. 1993 Feb 15; 268(5):3407-13.
Score: 0.027
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Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2012 Jan 31; 51(4):857-66.
Score: 0.025
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Multiple isotope effects with alternative dinucleotide substrates as a probe of the malic enzyme reaction. Biochemistry. 1991 Jun 11; 30(23):5755-63.
Score: 0.024
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Modification of a thiol at the active site of the Ascaris suum NAD-malic enzyme results in changes in the rate-determining steps for oxidative decarboxylation of L-malate. Biochemistry. 1991 Jun 11; 30(23):5764-9.
Score: 0.024
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Use of primary deuterium and 15N isotope effects to deduce the relative rates of steps in the mechanisms of alanine and glutamate dehydrogenases. Biochemistry. 1988 Jun 28; 27(13):4814-22.
Score: 0.019
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Kinetics and mechanism of benzoylformate decarboxylase using 13C and solvent deuterium isotope effects on benzoylformate and benzoylformate analogues. Biochemistry. 1988 Mar 22; 27(6):2197-205.
Score: 0.019
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Chemical mechanism of the adenosine cyclic 3',5'-monophosphate dependent protein kinase from pH studies. Biochemistry. 1987 Jun 30; 26(13):4118-25.
Score: 0.018
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Protonation mechanism and location of rate-determining steps for the Ascaris suum nicotinamide adenine dinucleotide-malic enzyme reaction from isotope effects and pH studies. Biochemistry. 1986 Jan 14; 25(1):227-36.
Score: 0.016
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Solvent isotope effects on the reaction catalyzed by yeast hexokinase. Eur J Biochem. 1983 Aug 15; 134(3):571-4.
Score: 0.014
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Kinetic studies to determine the mechanism of regulation of bovine liver glutamate dehydrogenase by nucleotide effectors. Biochemistry. 1982 Jan 05; 21(1):113-6.
Score: 0.012
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Use of isotope effects and pH studies to determine the chemical mechanism of Bacillus subtilis L-alanine dehydrogenase. Biochemistry. 1981 Sep 29; 20(20):5655-61.
Score: 0.012
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pH variation of isotope effects in enzyme-catalyzed reactions. 1. Isotope- and pH-dependent steps the same. Biochemistry. 1981 Mar 31; 20(7):1797-805.
Score: 0.012
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Secondary deuterium and nitrogen-15 isotope effects in enzyme-catalyzed reactions. Chemical mechanism of liver alcohol dehydrogenase. Biochemistry. 1981 Mar 31; 20(7):1817-25.
Score: 0.012
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Evidence from nitrogen-15 and solvent deuterium isotope effects on the chemical mechanism of adenosine deaminase. Biochemistry. 1987 Nov 17; 26(23):7378-84.
Score: 0.005
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Stereoselective preparation of deuterated reduced nicotinamide adenine nucleotides and substrates by enzymatic synthesis. Anal Biochem. 1979 Jul 15; 96(2):334-40.
Score: 0.003