Header Logo

Connection

Paul Cook to Cysteine Synthase

Back to Details
This is a "connection" page, showing publications Paul Cook has written about Cysteine Synthase.
Paul Cook
Connection Strength
6.795
Cysteine Synthase
  1. The multifaceted pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase. Biochim Biophys Acta. 2011 Nov; 1814(11):1497-510.
    View in: PubMed
    Score: 0.369
  2. Identification of the structural determinants for the stability of substrate and aminoacrylate external Schiff bases in O-acetylserine sulfhydrylase-A. Biochemistry. 2010 Jul 27; 49(29):6093-103.
    View in: PubMed
    Score: 0.350
  3. (31)P NMR studies of O-acetylserine sulfhydrylase-B from Salmonella typhimurium. Arch Biochem Biophys. 2009 Jul 15; 487(2):85-90.
    View in: PubMed
    Score: 0.323
  4. Role of Histidine-152 in cofactor orientation in the PLP-dependent O-acetylserine sulfhydrylase reaction. Arch Biochem Biophys. 2008 Apr 15; 472(2):115-25.
    View in: PubMed
    Score: 0.295
  5. Effect of mutation of lysine-120, located at the entry to the active site of O-acetylserine sulfhydrylase-A from Salmonella typhimurium. Biochim Biophys Acta. 2008 Apr; 1784(4):629-37.
    View in: PubMed
    Score: 0.294
  6. Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes. Biochemistry. 2007 Jul 17; 46(28):8315-30.
    View in: PubMed
    Score: 0.282
  7. A three-dimensional homology model of the O-acetylserine sulfhydrylase-B from Salmonella typhimurium. Protein Pept Lett. 2006; 13(1):7-13.
    View in: PubMed
    Score: 0.255
  8. Mechanism of the addition half of the O-acetylserine sulfhydrylase-A reaction. Biochemistry. 2005 Apr 12; 44(14):5541-50.
    View in: PubMed
    Score: 0.243
  9. Structure and mechanism of O-acetylserine sulfhydrylase. J Biol Chem. 2004 Jun 25; 279(26):26803-6.
    View in: PubMed
    Score: 0.226
  10. Alpha,beta-elimination reaction of O-acetylserine sulfhydrylase. Is the pyridine ring required? Biochim Biophys Acta. 2003 Apr 11; 1647(1-2):66-9.
    View in: PubMed
    Score: 0.211
  11. Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction. Biochemistry. 2003 Jan 14; 42(1):106-13.
    View in: PubMed
    Score: 0.208
  12. Detection of intermediates in reactions catalyzed by PLP-dependent enzymes: O-acetylserine sulfhydrylase and serine-glyoxalate aminotransferase. Methods Enzymol. 2002; 354:223-37.
    View in: PubMed
    Score: 0.193
  13. Characterization of the allosteric anion-binding site of O-acetylserine sulfhydrylase. Biochemistry. 2001 Jun 26; 40(25):7446-52.
    View in: PubMed
    Score: 0.186
  14. Pyridoxal 5'-phosphate-dependent alpha,beta-elimination reactions: mechanism of O-acetylserine sulfhydrylase. Acc Chem Res. 2001 Jan; 34(1):49-59.
    View in: PubMed
    Score: 0.180
  15. Identification of an allosteric anion-binding site on O-acetylserine sulfhydrylase: structure of the enzyme with chloride bound. J Mol Biol. 2000 Oct 20; 303(2):279-86.
    View in: PubMed
    Score: 0.178
  16. O-acetylserine sulfhydrylase. Adv Enzymol Relat Areas Mol Biol. 2000; 74:185-234.
    View in: PubMed
    Score: 0.168
  17. Time-resolved fluorescence of O-acetylserine sulfhydrylase. Biochim Biophys Acta. 1999 Jan 11; 1429(2):317-30.
    View in: PubMed
    Score: 0.157
  18. Cysteine 42 is important for maintaining an integral active site for O-acetylserine sulfhydrylase resulting in the stabilization of the alpha-aminoacrylate intermediate. Biochemistry. 1998 Jul 28; 37(30):10597-604.
    View in: PubMed
    Score: 0.152
  19. Catalytic competence of O-acetylserine sulfhydrylase in the crystal probed by polarized absorption microspectrophotometry. J Mol Biol. 1998; 283(1):135-46.
    View in: PubMed
    Score: 0.146
  20. Time-resolved fluorescence of O-acetylserine sulfhydrylase catalytic intermediates. Biochemistry. 1997 Dec 09; 36(49):15419-27.
    View in: PubMed
    Score: 0.146
  21. Substitution of pyridoxal 5'-phosphate in the O-acetylserine sulfhydrylase from Salmonella typhimurium by cofactor analogs provides a test of the mechanism proposed for formation of the alpha-aminoacrylate intermediate. J Biol Chem. 1996 Oct 18; 271(42):25842-9.
    View in: PubMed
    Score: 0.135
  22. A change in the internal aldimine lysine (K42) in O-acetylserine sulfhydrylase to alanine indicates its importance in transimination and as a general base catalyst. Biochemistry. 1996 Oct 15; 35(41):13485-93.
    View in: PubMed
    Score: 0.135
  23. Tryptophan luminescence as a probe of enzyme conformation along the O-acetylserine sulfhydrylase reaction pathway. Biochemistry. 1996 Jun 25; 35(25):8392-400.
    View in: PubMed
    Score: 0.132
  24. Kinetic isotope effects as a probe of the beta-elimination reaction catalyzed by O-acetylserine sulfhydrylase. Biochemistry. 1996 May 21; 35(20):6358-65.
    View in: PubMed
    Score: 0.131
  25. Formation of the alpha-aminoacrylate immediate limits the overall reaction catalyzed by O-acetylserine sulfhydrylase. Biochemistry. 1996 Apr 16; 35(15):4776-83.
    View in: PubMed
    Score: 0.130
  26. Resolution of pyridoxal 5'-phosphate from O-acetylserine sulfhydrylase from Salmonella typhimurium and reconstitution of apoenzyme with cofactor and cofactor analogues as a probe of the cofactor binding site. Arch Biochem Biophys. 1995 Dec 01; 324(1):71-7.
    View in: PubMed
    Score: 0.127
  27. Identification and spectral characterization of the external aldimine of the O-acetylserine sulfhydrylase reaction. Biochemistry. 1995 Sep 26; 34(38):12152-60.
    View in: PubMed
    Score: 0.125
  28. Acid-base chemical mechanism of O-acetylserine sulfhydrylases-A and -B from pH studies. Biochemistry. 1995 Sep 26; 34(38):12311-22.
    View in: PubMed
    Score: 0.125
  29. Product binding to the alpha-carboxyl subsite results in a conformational change at the active site of O-acetylserine sulfhydrylase-A: evidence from fluorescence spectroscopy. Biochemistry. 1994 Feb 22; 33(7):1674-83.
    View in: PubMed
    Score: 0.112
  30. Isozyme-specific ligands for O-acetylserine sulfhydrylase, a novel antibiotic target. PLoS One. 2013; 8(10):e77558.
    View in: PubMed
    Score: 0.110
  31. Kinetic mechanisms of the A and B isozymes of O-acetylserine sulfhydrylase from Salmonella typhimurium LT-2 using the natural and alternative reactants. Biochemistry. 1993 Jun 29; 32(25):6433-42.
    View in: PubMed
    Score: 0.107
  32. Crystallization and preliminary X-ray data for the A-isozyme of O-acetylserine sulfhydrylase from Salmonella typhimurium. J Mol Biol. 1993 Jun 20; 231(4):1130-2.
    View in: PubMed
    Score: 0.107
  33. Fine tuning of the active site modulates specificity in the interaction of O-acetylserine sulfhydrylase isozymes with serine acetyltransferase. Biochim Biophys Acta. 2013 Jan; 1834(1):169-81.
    View in: PubMed
    Score: 0.102
  34. pH dependence of the absorbance and 31P NMR spectra of O-acetylserine sulfhydrylase in the absence and presence of O-acetyl-L-serine. Biochemistry. 1992 Mar 03; 31(8):2298-303.
    View in: PubMed
    Score: 0.098
  35. A rapid purification procedure and computer-assisted sulfide ion selective electrode assay for O-acetylserine sulfhydrylase from Salmonella typhimurium. Protein Expr Purif. 1990 Sep; 1(1):70-6.
    View in: PubMed
    Score: 0.088
  36. A two-step process controls the formation of the bienzyme cysteine synthase complex. J Biol Chem. 2010 Apr 23; 285(17):12813-22.
    View in: PubMed
    Score: 0.085
  37. Design of O-acetylserine sulfhydrylase inhibitors by mimicking nature. J Med Chem. 2010 Jan 14; 53(1):345-56.
    View in: PubMed
    Score: 0.084
  38. Interaction of serine acetyltransferase with O-acetylserine sulfhydrylase active site: evidence from fluorescence spectroscopy. Protein Sci. 2005 Aug; 14(8):2115-24.
    View in: PubMed
    Score: 0.062
  39. Surface-exposed tryptophan residues are essential for O-acetylserine sulfhydrylase structure, function, and stability. J Biol Chem. 2003 Sep 26; 278(39):37511-9.
    View in: PubMed
    Score: 0.053
  40. Ligand binding induces a large conformational change in O-acetylserine sulfhydrylase from Salmonella typhimurium. J Mol Biol. 1999 Aug 27; 291(4):941-53.
    View in: PubMed
    Score: 0.041
  41. Cysteine synthetase from Salmonella typhimurium LT-2. Aggregation, kinetic behavior, and effect of modifiers. J Biol Chem. 1978 Nov 10; 253(21):7874-9.
    View in: PubMed
    Score: 0.039
  42. Three-dimensional structure of O-acetylserine sulfhydrylase from Salmonella typhimurium. J Mol Biol. 1998; 283(1):121-33.
    View in: PubMed
    Score: 0.037
  43. Overall mechanism and rate equation for O-acetylserine sulfhydrylase. J Biol Chem. 1977 May 25; 252(10):3459.
    View in: PubMed
    Score: 0.035
  44. salmonella typhimurium/enzymol. Arch Biochem Biophys. 1977 Jan 15; 178(1):293-302.
    View in: PubMed
    Score: 0.034
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.