Paul Cook to Hydrogen-Ion Concentration
This is a "connection" page, showing publications Paul Cook has written about Hydrogen-Ion Concentration.
Connection Strength
2.931
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Evidence for an induced conformational change in the catalytic mechanism of homoisocitrate dehydrogenase for Saccharomyces cerevisiae: Characterization of the D271N mutant enzyme. Arch Biochem Biophys. 2015 Oct 15; 584:20-7.
Score: 0.122
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Supporting role of lysine 13 and glutamate 16 in the acid-base mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae. Arch Biochem Biophys. 2012 Jun 01; 522(1):57-61.
Score: 0.096
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The oxidation state of active site thiols determines activity of saccharopine dehydrogenase at low pH. Arch Biochem Biophys. 2011 Sep 15; 513(2):71-80.
Score: 0.092
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Site-directed mutagenesis as a probe of the acid-base catalytic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2009 Aug 04; 48(30):7305-12.
Score: 0.080
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Chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae. Biochemistry. 2009 Jun 30; 48(25):5899-907.
Score: 0.079
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Potassium is an activator of homoisocitrate dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2008 Oct 07; 47(40):10809-15.
Score: 0.075
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Evidence for a catalytic dyad in the active site of homocitrate synthase from Saccharomyces cerevisiae. Biochemistry. 2008 Jul 01; 47(26):6851-8.
Score: 0.074
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Roles of histidines 154 and 189 and aspartate 139 in the active site of serine acetyltransferase from Haemophilus influenzae. Biochemistry. 2008 Jun 17; 47(24):6322-8.
Score: 0.074
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Chemical mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2008 Apr 01; 47(13):4169-80.
Score: 0.072
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Effect of mutation of lysine-120, located at the entry to the active site of O-acetylserine sulfhydrylase-A from Salmonella typhimurium. Biochim Biophys Acta. 2008 Apr; 1784(4):629-37.
Score: 0.072
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Multiple roles of arginine 181 in binding and catalysis in the NAD-malic enzyme from Ascaris suum. Biochemistry. 2007 Dec 18; 46(50):14578-88.
Score: 0.071
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Control of ionizable residues in the catalytic mechanism of tryptophan synthase from Salmonella typhimurium. Biochemistry. 2007 Nov 13; 46(45):13223-34.
Score: 0.070
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Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes. Biochemistry. 2007 Jul 17; 46(28):8315-30.
Score: 0.069
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Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2007 Jun 26; 46(25):7625-36.
Score: 0.069
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A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2007 Jan 23; 46(3):871-82.
Score: 0.067
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Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2006 Oct 03; 45(39):12156-66.
Score: 0.066
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Mechanism of the addition half of the O-acetylserine sulfhydrylase-A reaction. Biochemistry. 2005 Apr 12; 44(14):5541-50.
Score: 0.059
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A catalytic triad is responsible for acid-base chemistry in the Ascaris suum NAD-malic enzyme. Biochemistry. 2005 Mar 08; 44(9):3626-35.
Score: 0.059
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The serine acetyltransferase reaction: acetyl transfer from an acylpantothenyl donor to an alcohol. Arch Biochem Biophys. 2005 Jan 01; 433(1):85-95.
Score: 0.058
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Chemical mechanism of the serine acetyltransferase from Haemophilus influenzae. Biochemistry. 2004 Dec 14; 43(49):15534-9.
Score: 0.058
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Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters. Biochim Biophys Acta. 2004 Sep 01; 1701(1-2):61-74.
Score: 0.057
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Tartrate dehydrogenase catalyzes the stepwise oxidative decarboxylation of D-malate with both NAD and thio-NAD. Biochemistry. 2002 Oct 08; 41(40):12193-9.
Score: 0.050
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Alternative substrates for malic enzyme: oxidative decarboxylation of L-aspartate. Biochemistry. 2002 Oct 08; 41(40):12200-3.
Score: 0.050
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Characterization of the allosteric anion-binding site of O-acetylserine sulfhydrylase. Biochemistry. 2001 Jun 26; 40(25):7446-52.
Score: 0.046
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Initial velocity, spectral, and pH studies of the serine-glyoxylate aminotransferase from Hyphomicrobiuim methylovorum. Arch Biochem Biophys. 2001 Apr 15; 388(2):267-75.
Score: 0.045
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pH variation of isotope effects in enzyme-catalyzed reactions. 1. Isotope- and pH-dependent steps the same. Biochemistry. 1981 Mar 31; 20(7):1797-805.
Score: 0.045
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pH variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase. Biochemistry. 1981 Mar 31; 20(7):1805-16.
Score: 0.045
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Lysine 199 is the general acid in the NAD-malic enzyme reaction. Biochemistry. 2000 Oct 03; 39(39):11955-60.
Score: 0.043
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Lysine 183 is the general base in the 6-phosphogluconate dehydrogenase-catalyzed reaction. Biochemistry. 1999 Aug 31; 38(35):11231-8.
Score: 0.040
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Time-resolved fluorescence of O-acetylserine sulfhydrylase. Biochim Biophys Acta. 1999 Jan 11; 1429(2):317-30.
Score: 0.038
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Glutamate 190 is a general acid catalyst in the 6-phosphogluconate-dehydrogenase-catalyzed reaction. Biochemistry. 1998 Nov 10; 37(45):15691-7.
Score: 0.038
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Multiple isotope effects as a probe of proton and hydride transfer in the 6-phosphogluconate dehydrogenase reaction. Biochemistry. 1998 Nov 10; 37(45):15698-702.
Score: 0.038
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Cysteine 42 is important for maintaining an integral active site for O-acetylserine sulfhydrylase resulting in the stabilization of the alpha-aminoacrylate intermediate. Biochemistry. 1998 Jul 28; 37(30):10597-604.
Score: 0.037
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Catalytic competence of O-acetylserine sulfhydrylase in the crystal probed by polarized absorption microspectrophotometry. J Mol Biol. 1998; 283(1):135-46.
Score: 0.036
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Kinetic and chemical mechanisms of the sheep liver 6-phosphogluconate dehydrogenase. Arch Biochem Biophys. 1996 Dec 15; 336(2):215-23.
Score: 0.033
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Substitution of pyridoxal 5'-phosphate in the O-acetylserine sulfhydrylase from Salmonella typhimurium by cofactor analogs provides a test of the mechanism proposed for formation of the alpha-aminoacrylate intermediate. J Biol Chem. 1996 Oct 18; 271(42):25842-9.
Score: 0.033
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Tryptophan luminescence as a probe of enzyme conformation along the O-acetylserine sulfhydrylase reaction pathway. Biochemistry. 1996 Jun 25; 35(25):8392-400.
Score: 0.032
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Kinetic isotope effects as a probe of the beta-elimination reaction catalyzed by O-acetylserine sulfhydrylase. Biochemistry. 1996 May 21; 35(20):6358-65.
Score: 0.032
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A pH-dependent allosteric transition in Ascaris suum phosphofructokinase distinct from that observed with fructose 2,6-bisphosphate. Arch Biochem Biophys. 1995 Oct 01; 322(2):410-6.
Score: 0.031
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Identification and spectral characterization of the external aldimine of the O-acetylserine sulfhydrylase reaction. Biochemistry. 1995 Sep 26; 34(38):12152-60.
Score: 0.031
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Acid-base chemical mechanism of O-acetylserine sulfhydrylases-A and -B from pH studies. Biochemistry. 1995 Sep 26; 34(38):12311-22.
Score: 0.031
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Acid-base chemical mechanism of aspartase from Hafnia alvei. Arch Biochem Biophys. 1995 Jun 20; 320(1):115-22.
Score: 0.030
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Acid-base catalytic mechanism and pH dependence of fructose 2,6-bisphosphate activation of the Ascaris suum phosphofructokinase. Biochemistry. 1995 Jun 20; 34(24):7781-7.
Score: 0.030
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Product binding to the alpha-carboxyl subsite results in a conformational change at the active site of O-acetylserine sulfhydrylase-A: evidence from fluorescence spectroscopy. Biochemistry. 1994 Feb 22; 33(7):1674-83.
Score: 0.027
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The 2'-phosphate of NADP is critical for optimum productive binding to 6-phosphogluconate dehydrogenase from Candida utilis. Arch Biochem Biophys. 1993 Sep; 305(2):551-8.
Score: 0.027
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pH dependence of the kinetic mechanism of the adenosine 3',5'-monophosphate dependent protein kinase catalytic subunit in the direction of magnesium adenosine 5'-diphosphate phosphorylation. Biochemistry. 1993 Jul 06; 32(26):6802-6.
Score: 0.026
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Acid-base catalytic mechanism of dihydropyrimidinase from pH studies. Biochemistry. 1993 May 18; 32(19):5160-6.
Score: 0.026
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Chemical mechanism of 6-phosphogluconate dehydrogenase from Candida utilis from pH studies. Biochemistry. 1993 Mar 02; 32(8):2041-6.
Score: 0.026
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Acid base catalytic mechanism of the dihydropyrimidine dehydrogenase from pH studies. J Biol Chem. 1993 Feb 15; 268(5):3407-13.
Score: 0.026
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Kinetic mechanism of the adenosine 3',5'-monophosphate dependent protein kinase catalytic subunit in the direction of magnesium adenosine 5'-diphosphate phosphorylation. Biochemistry. 1992 Oct 20; 31(41):9986-92.
Score: 0.025
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pH dependence of the absorbance and 31P NMR spectra of O-acetylserine sulfhydrylase in the absence and presence of O-acetyl-L-serine. Biochemistry. 1992 Mar 03; 31(8):2298-303.
Score: 0.024
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Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2012 Jan 31; 51(4):857-66.
Score: 0.024
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Mechanism of the aromatic aminotransferase encoded by the Aro8 gene from Saccharomyces cerevisiae. Arch Biochem Biophys. 2011 Dec 01; 516(1):67-74.
Score: 0.023
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A two-step process controls the formation of the bienzyme cysteine synthase complex. J Biol Chem. 2010 Apr 23; 285(17):12813-22.
Score: 0.021
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Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation. Chembiochem. 2010 Jan 25; 11(2):161-5.
Score: 0.021
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pH dependence of the kinetic parameters for the pyrophosphate-dependent phosphofructokinase reaction supports a proton-shuttle mechanism. Biochemistry. 1989 May 16; 28(10):4155-60.
Score: 0.020
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Inactivation of pyrophosphate-dependent phosphofructokinase from Propionibacterium freudenreichii by pyridoxal 5'-phosphate. Determination of the pH dependence of enzyme-reactant dissociation constants from protection against inactivation. J Biol Chem. 1988 Apr 15; 263(11):5135-40.
Score: 0.018
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Kinetics and mechanism of benzoylformate decarboxylase using 13C and solvent deuterium isotope effects on benzoylformate and benzoylformate analogues. Biochemistry. 1988 Mar 22; 27(6):2197-205.
Score: 0.018
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Correlation between hysteresis and allosteric properties for phosphofructokinase from Ascaris suum. J Biol Chem. 1987 Oct 15; 262(29):14063-7.
Score: 0.018
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Chemical mechanism of the adenosine cyclic 3',5'-monophosphate dependent protein kinase from pH studies. Biochemistry. 1987 Jun 30; 26(13):4118-25.
Score: 0.017
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Modification of an arginine residue essential for the activity of NAD-malic enzyme from Ascaris suum. Arch Biochem Biophys. 1987 May 15; 255(1):8-13.
Score: 0.017
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pH dependence of kinetic parameters for oxalacetate decarboxylation and pyruvate reduction reactions catalyzed by malic enzyme. Biochemistry. 1986 Jul 01; 25(13):3752-9.
Score: 0.016
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Protonation mechanism and location of rate-determining steps for the Ascaris suum nicotinamide adenine dinucleotide-malic enzyme reaction from isotope effects and pH studies. Biochemistry. 1986 Jan 14; 25(1):227-36.
Score: 0.016
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Diethylpyrocarbonate inactivation of NAD-malic enzyme from Ascaris suum. Arch Biochem Biophys. 1985 Aug 15; 241(1):67-74.
Score: 0.015
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The pH dependence of the reductive carboxylation of pyruvate by malic enzyme. Biochim Biophys Acta. 1985 Jun 10; 829(2):295-8.
Score: 0.015
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Determination of dissociation constants for enzyme-reactant complexes for NAD-malic enzyme by modulation of the thiol inactivation rate. Biochemistry. 1984 Nov 06; 23(23):5454-9.
Score: 0.014
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pH studies toward the elucidation of the auxiliary catalyst for pig heart aspartate aminotransferase. Biochemistry. 1983 Jan 18; 22(2):375-82.
Score: 0.013
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Use of isotope effects and pH studies to determine the chemical mechanism of Bacillus subtilis L-alanine dehydrogenase. Biochemistry. 1981 Sep 29; 20(20):5655-61.
Score: 0.012
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Use of pH studies to elucidate the catalytic mechanism of rabbit muscle creatine kinase. Biochemistry. 1981 Mar 03; 20(5):1204-10.
Score: 0.011
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Glutamate 325 is a general acid-base catalyst in the reaction catalyzed by fructose-2,6-bisphosphatase. Biochemistry. 2000 Dec 26; 39(51):16238-43.
Score: 0.011
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Chemical mechanism of the fructose-6-phosphate,2-kinase reaction from the pH dependence of kinetic parameters of site-directed mutants of active site basic residues. Biochemistry. 1997 Jul 22; 36(29):8775-84.
Score: 0.009
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Purification, characterization, and kinetics of porcine recombinant dihydropyrimidine dehydrogenase. Protein Expr Purif. 1997 Jul; 10(2):185-91.
Score: 0.009
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Molecular basis for the isozymes of bovine glucose-6-phosphate isomerase. Arch Biochem Biophys. 1988 May 15; 263(1):96-106.
Score: 0.005
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Evidence from nitrogen-15 and solvent deuterium isotope effects on the chemical mechanism of adenosine deaminase. Biochemistry. 1987 Nov 17; 26(23):7378-84.
Score: 0.004
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Reaction of Ascaris suum phosphofructokinase with diethylpyrocarbonate. Inactivation and desensitization to allosteric modulation. J Biol Chem. 1987 Oct 15; 262(29):14068-73.
Score: 0.004
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Solvent isotope effects on the reaction catalyzed by yeast hexokinase. Eur J Biochem. 1983 Aug 15; 134(3):571-4.
Score: 0.003