Robert Matts to HSP90 Heat-Shock Proteins
This is a "connection" page, showing publications Robert Matts has written about HSP90 Heat-Shock Proteins.
Connection Strength
7.998
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A High-Throughput Screen for Inhibitors of the Hsp90-Chaperone Machine. Methods Mol Biol. 2018; 1709:87-96.
Score: 0.563
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Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex. PLoS One. 2014; 9(3):e90054.
Score: 0.432
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Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins. Biochim Biophys Acta. 2012 Jun; 1823(6):1092-101.
Score: 0.378
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Approaches for defining the Hsp90-dependent proteome. Biochim Biophys Acta. 2012 Mar; 1823(3):656-67.
Score: 0.363
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Elucidation of the Hsp90 C-terminal inhibitor binding site. ACS Chem Biol. 2011 Aug 19; 6(8):800-7.
Score: 0.356
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Gambogic acid, a natural product inhibitor of Hsp90. J Nat Prod. 2011 May 27; 74(5):1085-92.
Score: 0.353
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A systematic protocol for the characterization of Hsp90 modulators. Bioorg Med Chem. 2011 Jan 01; 19(1):684-92.
Score: 0.342
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Assays for identification of Hsp90 inhibitors and biochemical methods for discriminating their mechanism of action. Curr Top Med Chem. 2009; 9(15):1462-78.
Score: 0.302
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High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase. Bioorg Med Chem. 2007 Mar 01; 15(5):1939-46.
Score: 0.263
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Hsp90 functions to balance the phosphorylation state of Akt during C2C12 myoblast differentiation. Cell Signal. 2005 Dec; 17(12):1477-85.
Score: 0.244
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Cdk2: a genuine protein kinase client of Hsp90 and Cdc37. Biochemistry. 2005 Nov 22; 44(46):15287-95.
Score: 0.243
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Exposure of protein kinase motifs that trigger binding of Hsp90 and Cdc37. Biochem Biophys Res Commun. 2005 Dec 23; 338(3):1447-54.
Score: 0.242
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Differential effects of Hsp90 inhibition on protein kinases regulating signal transduction pathways required for myoblast differentiation. Exp Cell Res. 2005 Jul 01; 307(1):212-23.
Score: 0.233
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Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37. J Biol Chem. 2004 Sep 17; 279(38):39975-81.
Score: 0.222
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Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions. Biochemistry. 2004 Jun 29; 43(25):8217-29.
Score: 0.221
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Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37. J Biol Chem. 2003 Oct 03; 278(40):38117-20.
Score: 0.208
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Evidence that protein phosphatase 5 functions to negatively modulate the maturation of the Hsp90-dependent heme-regulated eIF2alpha kinase. Biochemistry. 2002 May 28; 41(21):6770-9.
Score: 0.191
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Crystal structure of the middle and C-terminal domains of Hsp90a labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target. Acta Crystallogr D Struct Biol. 2022 May 01; 78(Pt 5):571-585.
Score: 0.189
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Selective Inhibition of the Hsp90a Isoform. Angew Chem Int Ed Engl. 2021 05 03; 60(19):10547-10551.
Score: 0.176
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Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase. J Biol Chem. 2001 Jan 05; 276(1):206-14.
Score: 0.173
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p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules. Biochemistry. 2000 Jun 27; 39(25):7631-44.
Score: 0.167
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Molybdate inhibits hsp90, induces structural changes in its C-terminal domain, and alters its interactions with substrates. Biochemistry. 1999 Mar 23; 38(12):3837-49.
Score: 0.153
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Modular folding and evidence for phosphorylation-induced stabilization of an hsp90-dependent kinase. J Biol Chem. 1998 Apr 03; 273(14):8475-82.
Score: 0.143
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Structure-guided design of an Hsp90ß N-terminal isoform-selective inhibitor. Nat Commun. 2018 01 30; 9(1):425.
Score: 0.142
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Proteomic Profiling of Hsp90 Inhibitors. Methods Mol Biol. 2018; 1709:139-162.
Score: 0.141
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The role of the 90-kDa heat-shock protein and its associated cohorts in stabilizing the heme-regulated eIF-2alpha kinase in reticulocyte lysates during heat stress. Eur J Biochem. 1997 Jun 01; 246(2):461-70.
Score: 0.135
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Hsp90 is obligatory for the heme-regulated eIF-2alpha kinase to acquire and maintain an activable conformation. J Biol Chem. 1997 Apr 25; 272(17):11648-56.
Score: 0.134
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Hsp90-mediated folding of the lymphoid cell kinase p56lck. Biochemistry. 1996 Oct 15; 35(41):13451-9.
Score: 0.129
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Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors. Assay Drug Dev Technol. 2013 Oct; 11(8):478-88.
Score: 0.105
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The anticancer drug AUY922 generates a proteomics fingerprint that is highly conserved among structurally diverse Hsp90 inhibitors. J Proteome Res. 2013 Aug 02; 12(8):3697-706.
Score: 0.103
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Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine. Mol Cell. 2012 Aug 10; 47(3):434-43.
Score: 0.096
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Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells. BMC Cancer. 2011 Oct 31; 11:468.
Score: 0.092
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Identification and initial SAR of silybin: an Hsp90 inhibitor. Bioorg Med Chem Lett. 2011 May 01; 21(9):2659-64.
Score: 0.087
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Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells. Prostate. 2010 Jan 01; 70(1):27-36.
Score: 0.081
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KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells. Mol Pharmacol. 2009 Dec; 76(6):1314-22.
Score: 0.079
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Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold. Bioorg Med Chem. 2009 Jan 15; 17(2):634-40.
Score: 0.075
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Derrubone, an inhibitor of the Hsp90 protein folding machinery. J Nat Prod. 2007 Dec; 70(12):2014-8.
Score: 0.070
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Direct interaction of the cell division cycle 37 homolog inhibits endothelial nitric oxide synthase activity. Circ Res. 2006 Feb 17; 98(3):335-41.
Score: 0.061
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Evidence for chaperone heterocomplexes containing both Hsp90 and VCP. Biochem Biophys Res Commun. 2005 Jun 17; 331(4):1331-7.
Score: 0.059
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High affinity binding of Hsp90 is triggered by multiple discrete segments of its kinase clients. Biochemistry. 2003 Nov 04; 42(43):12550-61.
Score: 0.053
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The molecular chaperone Hsp90 is required for signal transduction by wild-type Hck and maintenance of its constitutively active counterpart. Cell Growth Differ. 2001 Aug; 12(8):409-17.
Score: 0.045
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p50(Cdc37) can buffer the temperature-sensitive properties of a mutant of Hck. Mol Cell Biol. 2000 Sep; 20(18):6984-95.
Score: 0.042
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Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases. J Immunol. 2000 Mar 15; 164(6):2915-23.
Score: 0.041
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Disruption of zebrafish somite development by pharmacologic inhibition of Hsp90. Dev Biol. 1999 Jun 01; 210(1):56-70.
Score: 0.039
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Effect of geldanamycin on the kinetics of chaperone-mediated renaturation of firefly luciferase in rabbit reticulocyte lysate. Biochemistry. 1996 Oct 15; 35(41):13443-50.
Score: 0.032