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Gorbsky, Gary

One or more keywords matched the following items that are connected to Gorbsky, Gary

Item Type	Name
Concept	Kinetochores
Academic Article	Mad2 binding by phosphorylated kinetochores links error detection and checkpoint action in mitosis.
Academic Article	The 3F3/2 anti-phosphoepitope antibody binds the mitotically phosphorylated anaphase-promoting complex/cyclosome.
Academic Article	Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1.
Academic Article	Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint.
Academic Article	Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.
Academic Article	Phosphatase-regulated recruitment of the spindle- and kinetochore-associated (Ska) complex to kinetochores.
Academic Article	Multiple determinants and consequences of cohesion fatigue in mammalian cells.
Academic Article	Microtubules of the kinetochore fiber turn over in metaphase but not in anaphase.
Academic Article	Differential expression of a phosphoepitope at the kinetochores of moving chromosomes.
Academic Article	Microinjection of mitotic cells with the 3F3/2 anti-phosphoepitope antibody delays the onset of anaphase.
Academic Article	MPM-2 antibody-reactive phosphorylations can be created in detergent-extracted cells by kinetochore-bound and soluble kinases.
Academic Article	Rapid exchange of mammalian topoisomerase II alpha at kinetochores and chromosome arms in mitosis.
Academic Article	Kinetochores, microtubules and the metaphase checkpoint.
Academic Article	The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment.
Academic Article	The spindle checkpoint and chromosome segregation in meiosis.
Academic Article	Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events.
Academic Article	Protein dynamics at the kinetochore: cell cycle regulation of the metaphase to anaphase transition.
Academic Article	Elevating the level of Cdc34/Ubc3 ubiquitin-conjugating enzyme in mitosis inhibits association of CENP-E with kinetochores and blocks the metaphase alignment of chromosomes.
Academic Article	Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells.
Academic Article	Lysed cell models and isolated chromosomes for the study of kinetochore/centromere biochemistry in vitro.
Academic Article	Ska3 is required for spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis.
Academic Article	Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.
Academic Article	The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores.
Academic Article	Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E.
Academic Article	Tension-sensitive kinetochore phosphorylation in vitro.
Academic Article	Kinetochore "memory" of spindle checkpoint signaling in lysed mitotic cells.
Academic Article	The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis.
Academic Article	The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity.
Academic Article	Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores.
Academic Article	Multiple mechanisms of chromosome movement in vertebrate cells mediated through the Ndc80 complex and dynein/dynactin.
Academic Article	The spindle and kinetochore-associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit.
Academic Article	Chromosomes move poleward in anaphase along stationary microtubules that coordinately disassemble from their kinetochore ends.
Academic Article	Cell-cycle-regulated localization of tyrosine and threonine phosphoepitopes at the kinetochores of mitotic chromosomes.
Academic Article	Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint.
Grant	Chromosome Movement in Prometaphase
Grant	Understanding Cell Division
Grant	A Cell Dynamics Microscope for Live Cell Fluorescence
Academic Article	Mps1 promotes poleward chromosome movements in meiotic prometaphase.
Academic Article	More than two populations of microtubules comprise the dynamic mitotic spindle.

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Kinetochores