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One or more keywords matched the following items that are connected to Bourne, Christina
Item TypeName
Concept Toxin-Antitoxin Systems
Concept Amino Acid Sequence
Concept Binding Sites
Concept Drug Screening Assays, Antitumor
Concept Nucleic Acid Conformation
Concept Microbial Sensitivity Tests
Concept Molecular Sequence Data
Concept Molecular Structure
Concept Signal Transduction
Concept Staphylococcal Infections
Concept Staphylococcus
Concept Staphylococcus aureus
Concept Stereoisomerism
Concept Structure-Activity Relationship
Concept Substrate Specificity
Concept Protein Structure, Secondary
Concept Protein Structure, Tertiary
Concept Sequence Alignment
Concept Genome, Bacterial
Concept Protein Structure, Quaternary
Concept Space Flight
Concept United States
Concept Chemistry Techniques, Synthetic
Concept Structural Homology, Protein
Concept High-Throughput Screening Assays
Concept National Institute of Allergy and Infectious Diseases (U.S.)
Concept Molecular Docking Simulation
Academic Article Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity.
Academic Article Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis.
Academic Article The structure and competitive substrate inhibition of dihydrofolate reductase from Enterococcus faecalis reveal restrictions to cofactor docking.
Academic Article Comparison of the three-dimensional structures of a human Bence-Jones dimer crystallized on Earth and aboard US Space Shuttle Mission STS-95.
Academic Article Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1.
Academic Article Classifying compound mechanism of action for linking whole cell phenotypes to molecular targets.
Academic Article Inhibition of bacterial dihydrofolate reductase by 6-alkyl-2,4-diaminopyrimidines.
Academic Article Synthesis and biological evaluation of 2,4-diaminopyrimidine-based antifolate drugs against Bacillus anthracis.
Academic Article Identification of novel potential antibiotics against Staphylococcus using structure-based drug screening targeting dihydrofolate reductase.
Academic Article Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis.
Academic Article Evaluation of New Dihydrophthalazine-Appended 2,4-Diaminopyrimidines against Bacillus anthracis: Improved Syntheses Using a New Pincer Complex.
Academic Article Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase.
Academic Article Identifying a Molecular Mechanism That Imparts Species-Specific Toxicity to YoeB Toxins.
Academic Article A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly.
Academic Article Structure-activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase.
Academic Article Comparative Study of the Frech Catalyst with Two Conventional Catalysts in the Heck Synthesis of 2,4-Diaminopyrimidine-based Antibiotics.
Academic Article Microwave-assisted Heck Synthesis of Substituted 2,4-Diaminopyrimidine-based Antibiotics.
Academic Article Toxin-Antitoxin Modules Are Pliable Switches Activated by Multiple Protease Pathways.
Academic Article The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti-gyrase antibiotics.
Academic Article Evaluating the Potential for Cross-Interactions of Antitoxins in Type II TA Systems.
Academic Article Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody.
Academic Article Global structural changes in hepatitis B virus capsids induced by the assembly effector HAP1.
Academic Article In vitro screening for molecules that affect virus capsid assembly (and other protein association reactions).
Academic Article Small-molecule effectors of hepatitis B virus capsid assembly give insight into virus life cycle.
Academic Article A mutant hepatitis B virus core protein mimics inhibitors of icosahedral capsid self-assembly.
Academic Article High-throughput screening of a diversity collection using biodefense category A and B priority pathogens.
Academic Article Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery.
Academic Article Bacterial Growth Mindset: Structural Plasticity in Defense Systems.
Academic Article A YoeB toxin cleaves both RNA and DNA.
Academic Article Molecular Basis for the Substrate Promiscuity of Isopentenyl Phosphate Kinase from Candidatus methanomethylophilus alvus.
Academic Article ParD Antitoxin Hotspot Alters a Disorder-to-Order Transition upon Binding to Its Cognate ParE Toxin, Lessening Its Interaction Affinity and Increasing Its Protease Degradation Kinetics.
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