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The small molecule inhibitor G6 significantly reduces bone marrow fibrosis and the mutant burden in a mouse model of Jak2-mediated myelofibrosis.
Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mouse model of polycythemia vera.
Quantitative analyses of myelofibrosis by determining hydroxyproline.
Bone marrow fibrosis in primary myelofibrosis: pathogenic mechanisms and the role of TGF-ß.
Efficacy of ALK5 inhibition in myelofibrosis.
ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis.
miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2.
Tyrosine Kinase JAK2 and Myeloproliferative Disorders