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Mitogen-Activated Protein Kinase 1
Protein Kinase Inhibitors
p38 Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases
MAPK-activated protein kinase-2 (MK2)-mediated formation and phosphorylation-regulated dissociation of the signal complex consisting of p38, MK2, Akt, and Hsp27.
The small molecule inhibitor G6 significantly reduces bone marrow fibrosis and the mutant burden in a mouse model of Jak2-mediated myelofibrosis.
SU11652 Inhibits tyrosine kinase activity of FLT3 and growth of MV-4-11 cells.
Elevated levels of mast cells are involved in pruritus associated with polycythemia vera in JAK2V617F transgenic mice.
Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth.
Generation and characterization of a JAK2V617F-containing erythroleukemia cell line.
Blocking the function of tyrosine phosphatase SHP-2 by targeting its Src homology 2 domains.
Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling.
The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow.
Tea contains potent inhibitors of tyrosine phosphatase PTP1B.
miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2.