| Item Type | Name |
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Concept
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Calcium-Binding Proteins
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Concept
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Blood Proteins
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Concept
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Bacterial Outer Membrane Proteins
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Concept
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Bacterial Proteins
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Concept
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Carrier Proteins
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Concept
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Chromosomal Proteins, Non-Histone
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Concept
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High Mobility Group Proteins
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Concept
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Heat-Shock Proteins
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Concept
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Hemolysin Proteins
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Concept
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Nuclear Proteins
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Concept
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Microfilament Proteins
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Concept
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Recombinant Fusion Proteins
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Concept
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Recombinant Proteins
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Concept
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Protozoan Proteins
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Concept
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Proteins
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Concept
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Eosinophil Granule Proteins
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Concept
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Pore Forming Cytotoxic Proteins
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Concept
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Fungal Proteins
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Concept
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Membrane Proteins
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Academic Article
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The primary structure of Clostridium septicum alpha-toxin exhibits similarity with that of Aeromonas hydrophila aerolysin.
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Academic Article
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Activation and mechanism of Clostridium septicum alpha toxin.
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Academic Article
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The propeptide of Clostridium septicum alpha toxin functions as an intramolecular chaperone and is a potent inhibitor of alpha toxin-dependent cytolysis.
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Academic Article
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Clostridium septicum alpha-toxin is proteolytically activated by furin.
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Academic Article
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Expression and properties of an aerolysin--Clostridium septicum alpha toxin hybrid protein.
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Academic Article
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Arresting pore formation of a cholesterol-dependent cytolysin by disulfide trapping synchronizes the insertion of the transmembrane beta-sheet from a prepore intermediate.
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Academic Article
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Mechanism of membrane insertion of a multimeric beta-barrel protein: perfringolysin O creates a pore using ordered and coupled conformational changes.
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Academic Article
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Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit beta-strand alignment.
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Academic Article
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Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin.
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Academic Article
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Molecular basis of listeriolysin O pH dependence.
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Academic Article
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Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9.
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Academic Article
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Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity.
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Academic Article
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The cholesterol-dependent cytolysin signature motif: a critical element in the allosteric pathway that couples membrane binding to pore assembly.
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Academic Article
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Disulfide-bond scanning reveals assembly state and ß-strand tilt angle of the PFO ß-barrel.
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Academic Article
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Broadly protective protein-based pneumococcal vaccine composed of pneumolysin toxoid-CbpA peptide recombinant fusion protein.
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Academic Article
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Perfringolysin O: The Underrated Clostridium perfringens Toxin?
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Academic Article
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Ionic interactions between proteins in nonequilibrium pH gradient electrophoresis: histones affect the migration of high mobility group nonhistone chromatin proteins.
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Academic Article
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Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors.
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Academic Article
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The mechanism of membrane insertion for a cholesterol-dependent cytolysin: a novel paradigm for pore-forming toxins.
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Academic Article
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The cholesterol-dependent cytolysins.
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Academic Article
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Clostridium septicum alpha-toxin is active against the parasitic protozoan Toxoplasma gondii and targets members of the SAG family of glycosylphosphatidylinositol-anchored surface proteins.
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Academic Article
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Assembly and topography of the prepore complex in cholesterol-dependent cytolysins.
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Academic Article
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The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin.
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Academic Article
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Crystallization and preliminary X-ray analysis of the human-specific toxin intermedilysin.
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Academic Article
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Vertical collapse of a cytolysin prepore moves its transmembrane beta-hairpins to the membrane.
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Academic Article
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Intracellular glycosylphosphatidylinositols accumulate on endosomes: toxicity of alpha-toxin to Leishmania major.
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Academic Article
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Prepore to pore transition of a cholesterol-dependent cytolysin visualized by electron microscopy.
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Academic Article
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Plasma membrane cholesterol content affects nitric oxide diffusion dynamics and signaling.
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Academic Article
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The pore-forming toxin listeriolysin O mediates a novel entry pathway of L. monocytogenes into human hepatocytes.
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Academic Article
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The Apicomplexan CDC/MACPF-like pore-forming proteins.
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Academic Article
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The Cholesterol-dependent Cytolysin Membrane-binding Interface Discriminates Lipid Environments of Cholesterol to Support ß-Barrel Pore Insertion.
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Academic Article
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Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation.
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Academic Article
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An Intermolecular p-Stacking Interaction Drives Conformational Changes Necessary to ß-Barrel Formation in a Pore-Forming Toxin.
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Academic Article
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Preclinical in vitro and in vivo profile of a highly-attenuated, broadly efficacious pneumolysin genetic toxoid.
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Academic Article
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Immunotherapy targeting the Streptococcus pyogenes M protein or streptolysin O to treat or prevent influenza A superinfection.
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Academic Article
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A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related Proteins.
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Academic Article
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Capacity of listeriolysin O, streptolysin O, and perfringolysin O to mediate growth of Bacillus subtilis within mammalian cells.
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Academic Article
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Cloning and expression in Escherichia coli of the perfringolysin O (theta-toxin) gene from Clostridium perfringens and characterization of the gene product.
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Academic Article
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Nucleotide sequence of the gene for perfringolysin O (theta-toxin) from Clostridium perfringens: significant homology with the genes for streptolysin O and pneumolysin.
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Academic Article
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Transport and processing of staphylococcal alpha-toxin.
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Academic Article
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Clostridium perfringens invasiveness is enhanced by effects of theta toxin upon PMNL structure and function: the roles of leukocytotoxicity and expression of CD11/CD18 adherence glycoprotein.
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Academic Article
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Beta-barrel pore-forming toxins: intriguing dimorphic proteins.
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Academic Article
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Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin.
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Academic Article
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Kinetic aspects of the aggregation of Clostridium perfringens theta-toxin on erythrocyte membranes. A fluorescence energy transfer study.
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Academic Article
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The domains of a cholesterol-dependent cytolysin undergo a major FRET-detected rearrangement during pore formation.
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Academic Article
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Evidence that Clostridium perfringens theta-toxin induces colloid-osmotic lysis of erythrocytes.
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Academic Article
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Helical crystallization on nickel-lipid nanotubes: perfringolysin O as a model protein.
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Academic Article
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Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins.
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Academic Article
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Pore-forming activity of alpha-toxin is essential for clostridium septicum-mediated myonecrosis.
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Academic Article
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Purification and characterization of toxin B from Clostridium difficile.
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Academic Article
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Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface.
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Academic Article
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Structural studies of Streptococcus pyogenes streptolysin O provide insights into the early steps of membrane penetration.
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Academic Article
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The impact of pneumolysin on the macrophage response to Streptococcus pneumoniae is strain-dependent.
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Academic Article
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The Unique Molecular Choreography of Giant Pore Formation by the Cholesterol-Dependent Cytolysins of Gram-Positive Bacteria.
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Academic Article
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Purification and partial characterization of a putative precursor to staphylococcal enterotoxin B.
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Academic Article
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The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin.
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Academic Article
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Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Streptococcus pneumoniae Infection.
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Academic Article
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A listeriolysin O subunit vaccine is protective against Listeria monocytogenes.
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Academic Article
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Crystallization and preliminary X-ray analysis of a thiol-activated cytolysin.
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Academic Article
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Generation of a membrane-bound, oligomerized pre-pore complex is necessary for pore formation by Clostridium septicum alpha toxin.
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Academic Article
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Identification of a membrane-spanning domain of the thiol-activated pore-forming toxin Clostridium perfringens perfringolysin O: an alpha-helical to beta-sheet transition identified by fluorescence spectroscopy.
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Academic Article
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The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae.
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Academic Article
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Self-interaction of pneumolysin, the pore-forming protein toxin of Streptococcus pneumoniae.
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Academic Article
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The mechanism of pore assembly for a cholesterol-dependent cytolysin: formation of a large prepore complex precedes the insertion of the transmembrane beta-hairpins.
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Academic Article
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Clostridium perfringens beta-toxin forms potential-dependent, cation-selective channels in lipid bilayers.
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Academic Article
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Monomer-monomer interactions drive the prepore to pore conversion of a beta-barrel-forming cholesterol-dependent cytolysin.
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Academic Article
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Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin.
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Academic Article
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Specific protein-membrane contacts are required for prepore and pore assembly by a cholesterol-dependent cytolysin.
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Academic Article
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Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions.
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Academic Article
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Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin.
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Academic Article
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Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding.
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Academic Article
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Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins.
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Academic Article
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Mouse, but not human, ApoB-100 lipoprotein cholesterol is a potent innate inhibitor of Streptococcus pneumoniae pneumolysin.
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Academic Article
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Cardiac myocyte dysfunction induced by streptolysin O is membrane pore and calcium dependent.
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Academic Article
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An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin.
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Academic Article
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Conformational changes during pore formation by the perforin-related protein pleurotolysin.
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Academic Article
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Multivalent Pneumococcal Protein Vaccines Comprising Pneumolysoid with Epitopes/Fragments of CbpA and/or PspA Elicit Strong and Broad Protection.
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Academic Article
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Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
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Academic Article
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Efficient gene delivery and expression in mammalian cells using DNA coupled with perfringolysin O.
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Academic Article
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Effects of Clostridium perfringens recombinant and crude phospholipase C and theta-toxin on rabbit hemodynamic parameters.
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Academic Article
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Clostridial gas gangrene: evidence that alpha and theta toxins differentially modulate the immune response and induce acute tissue necrosis.
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Grant
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Pore Formation by Cholesterol Dependent Cytolysins
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Grant
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A Novel Cholesterol-Dependent Cytolysin Receptor
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Grant
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Pore Formation by Cholesterol Dependent Cytolysins
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Academic Article
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A proteolytically activated antimicrobial toxin encoded on a mobile plasmid of Bacteroidales induces a protective response.
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Academic Article
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Pore-forming activity of S. pneumoniae pneumolysin disrupts the paracellular localization of the epithelial adherens junction protein E-cadherin.
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