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Myositis, Inclusion Body
Inclusion Bodies, Viral
TDP-43 accumulation in inclusion body myopathy muscle suggests a common pathogenic mechanism with frontotemporal dementia.
Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease.
Novel GNE mutations in two phenotypically distinct HIBM2 patients.
Identification of the orthopoxvirus p4c gene, which encodes a structural protein that directs intracellular mature virus particles into A-type inclusions.
Transgenic expression of inclusion body myopathy associated mutant p97/VCP causes weakness and ubiquitinated protein inclusions in mice.
Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease.