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Concept
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Mice, Inbred C57BL
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Concept
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Mice, Inbred ICR
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Concept
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Mice, Transgenic
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Concept
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Mice, Knockout
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Concept
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Mice
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Concept
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Mice, 129 Strain
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Academic Article
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Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline.
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Academic Article
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Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation.
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Academic Article
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Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging.
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Academic Article
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Cerebral venous congestion promotes blood-brain barrier disruption and neuroinflammation, impairing cognitive function in mice.
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Academic Article
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Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation-induced impairment of neurovascular coupling responses protecting cognitive function in mice.
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Academic Article
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Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects.
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Academic Article
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Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood.
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Academic Article
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Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain.
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Academic Article
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Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research.
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Academic Article
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Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects.
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Academic Article
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Fusogenic liposomes effectively deliver resveratrol to the cerebral microcirculation and improve endothelium-dependent neurovascular coupling responses in aged mice.
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Academic Article
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Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice.
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Academic Article
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Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging.
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Academic Article
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Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice.
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Academic Article
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Endothelial dysfunction and angiogenesis impairment in the ageing vasculature.
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Academic Article
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Overexpression of catalase targeted to mitochondria improves neurovascular coupling responses in aged mice.
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Academic Article
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Age-related alterations of articular cartilage in pituitary adenylate cyclase-activating polypeptide (PACAP) gene-deficient mice.
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Academic Article
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Purinergic glio-endothelial coupling during neuronal activity: role of P2Y1 receptors and eNOS in functional hyperemia in the mouse somatosensory cortex.
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Academic Article
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Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.
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Academic Article
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Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence.
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Academic Article
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Demonstration of impaired neurovascular coupling responses in TG2576 mouse model of Alzheimer's disease using functional laser speckle contrast imaging.
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Academic Article
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Correction to: Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice.
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Academic Article
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Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.
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Academic Article
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IGF-1 Deficiency Promotes Pathological Remodeling of Cerebral Arteries: A Potential Mechanism Contributing to the Pathogenesis of Intracerebral Hemorrhages in Aging.
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Academic Article
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Age-Related Alterations in Gait Function in Freely Moving Male C57BL/6 Mice: Translational Relevance of Decreased Cadence and Increased Gait Variability.
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Academic Article
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Effects of the Poly(ADP-Ribose) Polymerase Inhibitor Olaparib in Cerulein-Induced Pancreatitis.
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Academic Article
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Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase.
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Academic Article
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Aging impairs myogenic adaptation to pulsatile pressure in mouse cerebral arteries.
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Academic Article
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IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging.
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Academic Article
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Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice.
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Academic Article
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Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment.
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Academic Article
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Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice.
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Academic Article
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Whole brain irradiation in mice causes long-term impairment in astrocytic calcium signaling but preserves astrocyte-astrocyte coupling.
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Academic Article
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Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension.
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Academic Article
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IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice.
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Academic Article
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Aging Exacerbates Pressure-Induced Mitochondrial Oxidative Stress in Mouse Cerebral Arteries.
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Academic Article
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Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection.
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Academic Article
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IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis.
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Academic Article
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Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice.
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Academic Article
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Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass.
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Academic Article
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Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice.
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Academic Article
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Increases in hypertension-induced cerebral microhemorrhages exacerbate gait dysfunction in a mouse model of Alzheimer's disease.
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Academic Article
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Midlife Obesity Impairs Neurovascular Coupling Responses.
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Academic Article
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IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging.
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Academic Article
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Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by longitudinal intravital two-photon microscopy and optical coherence tomography.
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Academic Article
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Effect of genetic depletion of MMP-9 on neurological manifestations of hypertension-induced intracerebral hemorrhages in aged mice.
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Academic Article
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Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice.
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Academic Article
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Early manifestation of gait alterations in the Tg2576 mouse model of Alzheimer's disease.
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Academic Article
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Animal reservoirs of SARS-CoV-2: calculable COVID-19 risk for older adults from animal to human transmission.
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Academic Article
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Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype.
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Academic Article
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Increased Susceptibility to Cerebral Microhemorrhages Is Associated With Imaging Signs of Microvascular Degeneration in the Retina in an Insulin-Like Growth Factor 1 Deficient Mouse Model of Accelerated Aging.
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Academic Article
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Cerebral venous congestion exacerbates cerebral microhemorrhages in mice.
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Academic Article
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Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain.
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Academic Article
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Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling.
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Academic Article
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Measurements of cerebral microvascular blood flow, oxygenation, and morphology in a mouse model of whole-brain irradiation-induced cognitive impairment by two-photon microscopy and optical coherence tomography: evidence for microvascular injury in the cerebral white matter.
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Academic Article
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Imaging the time course, morphology, neuronal tissue compression, and resolution of cerebral microhemorrhages in mice using intravital two-photon microscopy: insights into arteriolar, capillary, and venular origin.
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Academic Article
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Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)-induced chemobrain.
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Academic Article
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Elimination of senescent cells by treatment with Navitoclax/ABT263 reverses whole brain irradiation-induced blood-brain barrier disruption in the mouse brain.
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Academic Article
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Whole brain irradiation-induced endothelial dysfunction in the mouse brain.
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Academic Article
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Preventing spontaneous cerebral microhemorrhages in aging mice: a novel approach targeting cellular senescence with ABT263/navitoclax.
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Academic Article
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Endothelial deficiency of insulin-like growth factor-1 receptor leads to blood-brain barrier disruption and accelerated endothelial senescence in mice, mimicking aspects of the brain aging phenotype.
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Academic Article
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Rejuvenation of cerebromicrovascular function in aged mice through heterochronic parabiosis: insights into neurovascular coupling and the impact of young blood factors.
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Academic Article
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Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence.
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