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Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1.
Disruption of cyclooxygenase-1 gene results in an impaired response to radiation injury.
Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2.
Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage.
CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury.
Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression.
Clinical implications of prostaglandin inhibition in the small bowel.