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Gaffney, Patrick

One or more keywords matched the following items that are connected to Gaffney, Patrick

Item Type	Name
Concept	Risk
Concept	Risk Factors
Concept	Risk Assessment
Academic Article	Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus.
Academic Article	Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus.
Academic Article	High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups.
Academic Article	Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations.
Academic Article	Variation in the ATP-binding cassette transporter 2 gene is a separate risk factor for systemic lupus erythematosus within the MHC.
Academic Article	Variation in the upstream region of P-Selectin (SELP) is a risk factor for SLE.
Academic Article	Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis.
Academic Article	Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression.
Academic Article	Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production.
Academic Article	Association of Epstein-Barr virus serological reactivation with transitioning to systemic lupus erythematosus in at-risk individuals.
Academic Article	The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus.
Academic Article	The genomics of autoimmune disease in the era of genome-wide association studies and beyond.
Academic Article	Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus.
Academic Article	Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations.
Academic Article	Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups.
Academic Article	Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus.
Academic Article	Polygenic risk assessment reveals pleiotropy between sarcoidosis and inflammatory disorders in the context of genetic ancestry.
Academic Article	Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis.
Academic Article	A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus.
Academic Article	Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus.
Academic Article	A polymorphism within IL21R confers risk for systemic lupus erythematosus.
Academic Article	Exon 6 variants carried on systemic lupus erythematosus (SLE) risk haplotypes modulate IRF5 function.
Academic Article	Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus.
Academic Article	A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus.
Academic Article	Effects of IRF5 lupus risk haplotype on pathways predicted to influence B cell functions.
Academic Article	Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression.
Academic Article	Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks.
Academic Article	Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients.
Academic Article	Role of Systemic Lupus Erythematosus Risk Variants With Opposing Functional Effects as a Driver of Hypomorphic Expression of TNIP1 and Other Genes Within a Three-Dimensional Chromatin Network.
Academic Article	Specific combinations of HLA-DR2 and DR3 class II haplotypes contribute graded risk for disease susceptibility and autoantibodies in human SLE.
Academic Article	Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.
Academic Article	Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
Academic Article	Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes.
Academic Article	Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA.
Academic Article	Lupus risk variants in the PXK locus alter B-cell receptor internalization.
Academic Article	Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture.
Academic Article	Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.
Academic Article	Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma.
Grant	Candidate Causal Variants in Systemic Lupus Erythematosus
Grant	Epigenome-Guided Causal Variant Discovery and Mechanisms
Grant	TNFAIP3 (A20) and Susceptibility to Systemic Lupus Erythematosus
Grant	Comprehensive Candidate Pathway Analysis in SLE
Grant	Functional Mechanisms of Causal Variants in Systemic Lupus Erythematosus
Academic Article	Chromatin Looping Links Target Genes with Genetic Risk Loci for Dermatological Traits.
Grant	Disease and Race Specific Single-cell Epigenetic Mechanisms in Human SLE
Academic Article	Variants on the UBE2L3/YDJC Autoimmune Disease Risk Haplotype Increase UBE2L3 Expression by Modulating CCCTC-Binding Factor and YY1 Binding.
Academic Article	Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells.
Academic Article	Relationship Between a Vitamin D Genetic Risk Score and Autoantibodies Among First-Degree Relatives of Probands With Rheumatoid Arthritis and Systemic Lupus Erythematosus.

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