| Item Type | Name |
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Concept
|
Animals
|
|
Concept
|
Aging
|
|
Concept
|
Antineoplastic Agents
|
|
Concept
|
Calcium
|
|
Concept
|
Allergens
|
|
Concept
|
Calpain
|
|
Concept
|
Amino Acid Sequence
|
|
Concept
|
Acyltransferases
|
|
Concept
|
Carboxylic Ester Hydrolases
|
|
Concept
|
Blindness
|
|
Concept
|
Bacillus
|
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Concept
|
Base Sequence
|
|
Concept
|
Cathepsin D
|
|
Concept
|
Cattle
|
|
Concept
|
Cell Count
|
|
Concept
|
Binding Sites
|
|
Concept
|
Chromatography, High Pressure Liquid
|
|
Concept
|
Diabetes Mellitus, Experimental
|
|
Concept
|
Diabetes Mellitus, Type 1
|
|
Concept
|
Diabetes Mellitus, Type 2
|
|
Concept
|
Cloning, Molecular
|
|
Concept
|
Diabetic Nephropathies
|
|
Concept
|
Diabetic Retinopathy
|
|
Concept
|
Cysteine
|
|
Concept
|
Cystine
|
|
Concept
|
Extremities
|
|
Concept
|
Eye
|
|
Concept
|
Facial Bones
|
|
Concept
|
Endoribonucleases
|
|
Concept
|
Enzyme Activation
|
|
Concept
|
Enzyme Inhibitors
|
|
Concept
|
Enzyme-Linked Immunosorbent Assay
|
|
Concept
|
Ferrous Compounds
|
|
Concept
|
Dose-Response Relationship, Drug
|
|
Concept
|
Fibrosis
|
|
Concept
|
Heterozygote
|
|
Concept
|
Guanosine
|
|
Concept
|
Cyclic GMP
|
|
Concept
|
Guanylate Cyclase
|
|
Concept
|
Ribonuclease T1
|
|
Concept
|
Histidine
|
|
Concept
|
Electrophoresis, Polyacrylamide Gel
|
|
Concept
|
Electroretinography
|
|
Concept
|
Humans
|
|
Concept
|
Gene Expression Regulation
|
|
Concept
|
Genes, Dominant
|
|
Concept
|
Genes, Lethal
|
|
Concept
|
Genetic Vectors
|
|
Concept
|
Hydrogen-Ion Concentration
|
|
Concept
|
Light
|
|
Concept
|
Panax
|
|
Concept
|
Glial Fibrillary Acidic Protein
|
|
Concept
|
Lipid Bilayers
|
|
Concept
|
Liposomes
|
|
Concept
|
Ketones
|
|
Concept
|
Kidney Diseases
|
|
Concept
|
Kidney Tubules, Proximal
|
|
Concept
|
Kinetics
|
|
Concept
|
Macular Degeneration
|
|
Concept
|
Magnesium
|
|
Concept
|
Inflammation
|
|
Concept
|
Phosphatidylcholine-Sterol O-Acyltransferase
|
|
Concept
|
Injections, Intraperitoneal
|
|
Concept
|
Mutation
|
|
Concept
|
Nucleic Acid Conformation
|
|
Concept
|
Iron
|
|
Concept
|
Isoenzymes
|
|
Concept
|
Isomerism
|
|
Concept
|
Nerve Growth Factors
|
|
Concept
|
Methylation
|
|
Concept
|
Mice, Inbred BALB C
|
|
Concept
|
Mice, Inbred C57BL
|
|
Concept
|
Mice, Mutant Strains
|
|
Concept
|
Mice, Transgenic
|
|
Concept
|
Pollen
|
|
Concept
|
Microscopy, Electron, Scanning
|
|
Concept
|
Microsomes
|
|
Concept
|
Phenylalanine
|
|
Concept
|
Polyribonucleotides
|
|
Concept
|
Models, Biological
|
|
Concept
|
Models, Chemical
|
|
Concept
|
Models, Molecular
|
|
Concept
|
Phosphoric Diester Hydrolases
|
|
Concept
|
Phospholipids
|
|
Concept
|
Molecular Conformation
|
|
Concept
|
Prealbumin
|
|
Concept
|
Pigment Epithelium of Eye
|
|
Concept
|
Piperidines
|
|
Concept
|
Retina
|
|
Concept
|
Retinaldehyde
|
|
Concept
|
Retinoids
|
|
Concept
|
Penicillium
|
|
Concept
|
Rhodopsin
|
|
Concept
|
Sequence Homology, Nucleic Acid
|
|
Concept
|
Ribonuclease, Pancreatic
|
|
Concept
|
Ribonucleases
|
|
Concept
|
RNA, Messenger
|
|
Concept
|
Pyridinium Compounds
|
|
Concept
|
Rabbits
|
|
Concept
|
Radiation Injuries, Experimental
|
|
Concept
|
Temperature
|
|
Concept
|
Transfection
|
|
Concept
|
Tretinoin
|
|
Concept
|
Receptors, Cell Surface
|
|
Concept
|
Xenopus laevis
|
|
Concept
|
Isotretinoin
|
|
Concept
|
Receptors, LDL
|
|
Concept
|
Down-Regulation
|
|
Concept
|
Zebrafish
|
|
Concept
|
Blotting, Southern
|
|
Concept
|
Immunoblotting
|
|
Concept
|
Blotting, Western
|
|
Concept
|
Single-Strand Specific DNA and RNA Endonucleases
|
|
Concept
|
Streptomyces aureofaciens
|
|
Concept
|
Transducin
|
|
Concept
|
Genetic Therapy
|
|
Concept
|
Rats, Sprague-Dawley
|
|
Concept
|
Rats, Wistar
|
|
Concept
|
Rod Opsins
|
|
Concept
|
Fenretinide
|
|
Concept
|
Point Mutation
|
|
Concept
|
Sequence Analysis
|
|
Concept
|
Protein Structure, Secondary
|
|
Concept
|
Protein Structure, Tertiary
|
|
Concept
|
Intercellular Adhesion Molecule-1
|
|
Concept
|
Vision, Ocular
|
|
Concept
|
Vitamin A
|
|
Concept
|
Vitamin A Deficiency
|
|
Concept
|
Conserved Sequence
|
|
Concept
|
ATP-Binding Cassette Transporters
|
|
Concept
|
Chemokine CCL2
|
|
Concept
|
Mutagenesis, Site-Directed
|
|
Concept
|
Vascular Cell Adhesion Molecule-1
|
|
Concept
|
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
|
|
Concept
|
Baculoviridae
|
|
Concept
|
Neuroprotective Agents
|
|
Concept
|
Glutamic Acid
|
|
Concept
|
Sequence Alignment
|
|
Concept
|
Fluorescent Antibody Technique, Indirect
|
|
Concept
|
Bruch Membrane
|
|
Concept
|
Mutation, Missense
|
|
Concept
|
Reverse Transcriptase Polymerase Chain Reaction
|
|
Concept
|
Catalytic Domain
|
|
Concept
|
Sequence Analysis, Protein
|
|
Concept
|
Caspases
|
|
Concept
|
In Situ Nick-End Labeling
|
|
Concept
|
Interleukin-18
|
|
Concept
|
DNA, Complementary
|
|
Concept
|
Photoreceptor Cells, Vertebrate
|
|
Concept
|
Genetic Diseases, Inborn
|
|
Concept
|
Optic Atrophy, Hereditary, Leber
|
|
Concept
|
Mice, Knockout
|
|
Concept
|
Magnoliopsida
|
|
Concept
|
cis-trans-Isomerases
|
|
Concept
|
Amino Acid Substitution
|
|
Concept
|
Endostatins
|
|
Concept
|
Collagen Type XVIII
|
|
Concept
|
Ribonuclease P
|
|
Concept
|
Genetic Predisposition to Disease
|
|
Concept
|
Protein Conformation
|
|
Concept
|
Protein Denaturation
|
|
Concept
|
Retinol O-Fatty-Acyltransferase
|
|
Concept
|
Caveolin 1
|
|
Concept
|
Mice
|
|
Concept
|
Rats
|
|
Concept
|
Guanylate Cyclase-Activating Proteins
|
|
Concept
|
Retinol-Binding Proteins, Plasma
|
|
Concept
|
Trichoderma
|
|
Concept
|
Retinal Pigment Epithelium
|
|
Concept
|
Retinal Photoreceptor Cell Outer Segment
|
|
Concept
|
Opsins
|
|
Concept
|
Tyrosine
|
|
Concept
|
Ureteral Obstruction
|
|
Concept
|
Serpins
|
|
Concept
|
Up-Regulation
|
|
Concept
|
Gene Expression Regulation, Enzymologic
|
|
Concept
|
Embryonic Development
|
|
Concept
|
Papio anubis
|
|
Concept
|
Maternal Nutritional Physiological Phenomena
|
|
Concept
|
Protein Array Analysis
|
|
Concept
|
Tomography, Optical Coherence
|
|
Concept
|
Leukemia Inhibitory Factor
|
|
Concept
|
DNA Primers
|
|
Concept
|
Retinal Rod Photoreceptor Cells
|
|
Concept
|
Retinal Cone Photoreceptor Cells
|
|
Concept
|
Tandem Mass Spectrometry
|
|
Concept
|
NADPH Oxidases
|
|
Concept
|
Body Patterning
|
|
Concept
|
COS Cells
|
|
Concept
|
Retinal Dehydrogenase
|
|
Concept
|
STAT3 Transcription Factor
|
|
Concept
|
Mice, 129 Strain
|
|
Concept
|
Cytokine Receptor gp130
|
|
Concept
|
Zonula Occludens-1 Protein
|
|
Concept
|
Caveolins
|
|
Concept
|
Models, Animal
|
|
Concept
|
Static Electricity
|
|
Concept
|
Gene Knock-In Techniques
|
|
Concept
|
Axin Protein
|
|
Concept
|
Real-Time Polymerase Chain Reaction
|
|
Concept
|
Arginine
|
|
Concept
|
Aspergillus oryzae
|
|
Concept
|
Cell Survival
|
|
Concept
|
Chelating Agents
|
|
Concept
|
Chickens
|
|
Concept
|
Disease Models, Animal
|
|
Concept
|
DNA Mutational Analysis
|
|
Concept
|
Fluorescein Angiography
|
|
Concept
|
Fluorescence
|
|
Concept
|
Food Hypersensitivity
|
|
Concept
|
Fungi
|
|
Concept
|
Immunoenzyme Techniques
|
|
Concept
|
Immunohistochemistry
|
|
Concept
|
Membrane Lipids
|
|
Concept
|
Oligonucleotides
|
|
Concept
|
Oligoribonucleotides
|
|
Academic Article
|
Retinyl esters are the substrate for isomerohydrolase.
|
|
Academic Article
|
Visual cycle retinoid processing proteins are present in HEK293S cells.
|
|
Academic Article
|
RPE65 is the isomerohydrolase in the retinoid visual cycle.
|
|
Academic Article
|
Comparison of ocular pathologies in vitamin A-deficient mice and RPE65 gene knockout mice.
|
|
Academic Article
|
A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis.
|
|
Academic Article
|
Postnatal Chick Choroids Exhibit Increased Retinaldehyde Dehydrogenase Activity During Recovery From Form Deprivation Induced Myopia.
|
|
Academic Article
|
Interphotoreceptor Retinol-Binding Protein Ameliorates Diabetes-Induced Retinal Dysfunction and Neurodegeneration Through Rhodopsin.
|
|
Academic Article
|
A comparative study on the catalytic properties of guanyl-specific ribonucleases.
|
|
Academic Article
|
A route to 2',5'-oligoadenylates with increased stability towards phosphodiesterases.
|
|
Academic Article
|
Dissociation constants and thermal stability of complexes of Bacillus intermedius RNase and the protein inhibitor of Bacillus amyloliquefaciens RNase.
|
|
Academic Article
|
Expression, purification, and MALDI analysis of RPE65.
|
|
Academic Article
|
Identification of conserved histidines and glutamic acid as key residues for isomerohydrolase activity of RPE65, an enzyme of the visual cycle in the retinal pigment epithelium.
|
|
Academic Article
|
The roles of three palmitoylation sites of RPE65 in its membrane association and isomerohydrolase activity.
|
|
Academic Article
|
Light induces programmed cell death by activating multiple independent proteases in a cone photoreceptor cell line.
|
|
Academic Article
|
Identification of a novel palmitylation site essential for membrane association and isomerohydrolase activity of RPE65.
|
|
Academic Article
|
The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins.
|
|
Academic Article
|
Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane.
|
|
Academic Article
|
Negative charge of the glutamic acid 417 residue is crucial for isomerohydrolase activity of RPE65.
|
|
Academic Article
|
Transgenic Mice Overexpressing Serum Retinol-Binding Protein Develop Progressive Retinal Degeneration through a Retinoid-Independent Mechanism.
|
|
Academic Article
|
Correlative variations of the free energies for enzyme-substrate complex formation and the transition-state stabilization for RNases.
|
|
Academic Article
|
Mutational analysis of the active site of RNase of Bacillus intermedius (BINASE).
|
|
Academic Article
|
Identification of RDH10, an All-trans Retinol Dehydrogenase, in Retinal Muller Cells.
|
|
Academic Article
|
Two point mutations of RPE65 from patients with retinal dystrophies decrease the stability of RPE65 protein and abolish its isomerohydrolase activity.
|
|
Academic Article
|
Impacts of two point mutations of RPE65 from Leber's congenital amaurosis on the stability, subcellular localization and isomerohydrolase activity of RPE65.
|
|
Academic Article
|
Identification of the key residues determining the product specificity of isomerohydrolase.
|
|
Academic Article
|
Identification of key residues determining isomerohydrolase activity of human RPE65.
|
|
Academic Article
|
Primary structure and catalytic properties of extracellular ribonuclease of Bacillus circulans.
|
|
Academic Article
|
Determination of the nucleotide conformation in the productive enzyme-substrate complexes of RNA-depolymerases.
|
|
Academic Article
|
Retinoid processing in cone and Müller cell lines.
|
|
Academic Article
|
Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity.
|
|
Academic Article
|
RDH10 is the primary enzyme responsible for the first step of embryonic Vitamin A metabolism and retinoic acid synthesis.
|
|
Academic Article
|
Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity.
|
|
Academic Article
|
Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase- and nuclear factor kappa B-dependent and retinol-independent mechanism.
|
|
Academic Article
|
A Dominant Mutation in Rpe65, D477G, Delays Dark Adaptation and Disturbs the Visual Cycle in the Mutant Knock-In Mice.
|
|
Academic Article
|
Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration.
|
|
Academic Article
|
The Single Administration of a Chromophore Alleviates Neural Defects in Diabetic Retinopathy.
|
|
Academic Article
|
Stereoelectronic effects in RNase-catalysed reactions of dinucleoside phosphate cleavage.
|
|
Academic Article
|
The interplay of environmental luminance and genetics in the retinal dystrophy induced by the dominant RPE65 mutation.
|