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One or more keywords matched the following items that are connected to Sonntag, William
Item TypeName
Concept Aging
Concept Cellular Senescence
Academic Article Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression.
Academic Article Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response.
Academic Article Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.
Academic Article Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging.
Academic Article Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging.
Academic Article Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging.
Academic Article Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation-induced impairment of neurovascular coupling responses protecting cognitive function in mice.
Academic Article Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation.
Academic Article Age-related decline in peripheral vascular health predicts cognitive impairment.
Academic Article Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research.
Academic Article Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats.
Academic Article Insulin-like growth factor-1 selectively increases glucose utilization in brains of aged animals.
Academic Article The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing.
Academic Article Insulin-like growth factor-1 does not ameliorate the age-related decline in presumptive inhibitory synapses in layer 2 of rat sensorimotor cortex.
Academic Article Caloric restricted male rats demonstrate fewer synapses in layer 2 of sensorimotor cortex.
Academic Article Microvascular plasticity in aging.
Academic Article Of worms, flies, dwarfs, and things that go bump in the night.
Academic Article Biomarkers of aging: from primitive organisms to humans.
Academic Article Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems.
Academic Article Dendritic stability in a model of adult-onset IGF-I deficiency.
Academic Article Growth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin II expression in senescent rats.
Academic Article Aging reduces hypoxia-induced microvascular growth in the rodent hippocampus.
Academic Article Effects of short-term treadmill exercise training or growth hormone supplementation on diastolic function and exercise tolerance in old rats.
Academic Article How age impairs the response of the neuromuscular junction to nerve transection and repair: An experimental study in rats.
Academic Article Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation.
Academic Article Impaired bladder function in aging male rats.
Academic Article An assay for RNA oxidation induced abasic sites using the Aldehyde Reactive Probe.
Academic Article Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animal.
Academic Article Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory.
Academic Article Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients.
Academic Article Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
Academic Article Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice.
Academic Article Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats.
Academic Article Growth hormone, insulin-like growth factor-1 and the aging brain.
Academic Article Brain and cerebrovascular aging--new mechanisms and insights.
Academic Article CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging.
Academic Article Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging.
Academic Article Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-ß uptake in astrocytes.
Academic Article Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice.
Academic Article Accelerated decline in cognition in a mouse model of increased oxidative stress.
Academic Article Effects of aging and dietary restriction on tissue protein synthesis: relationship to plasma insulin-like growth factor-1.
Academic Article Increased pituitary response to somatostatin in aging male rats: relationship to somatostatin receptor number and affinity.
Academic Article Growth hormone releasing hormone induced release of growth hormone in aging male rats: dependence on pharmacological manipulation and endogenous somatostatin release.
Academic Article Pituitary growth hormone and hypothalamic somatostatin in young female rats versus old constant estrous female rats.
Academic Article Effects of CNS active drugs and somatostatin antiserum on growth hormone release in young and old male rats.
Academic Article Decreases in growth hormone receptor signal transduction contribute to the decline in insulin-like growth factor I gene expression with age.
Academic Article Moderate caloric restriction prevents the age-related decline in growth hormone receptor signal transduction.
Academic Article Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood flow in aged rats.
Academic Article Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determination.
Academic Article Physical performance and longevity in aged rats.
Academic Article A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan.
Academic Article Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system.
Academic Article Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus.
Academic Article Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span.
Academic Article Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability.
Academic Article Growth hormone and aging: Regulation, signal transduction and replacement therapy.
Academic Article Does senescence give rise to disease?
Academic Article Mechanisms of vascular aging: new perspectives.
Academic Article Age-related alterations in retinal neurovascular and inflammatory transcripts.
Academic Article Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment.
Academic Article Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats.
Academic Article Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa).
Academic Article Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosensitivity.
Academic Article Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice.
Academic Article Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats.
Academic Article Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline.
Academic Article Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.
Academic Article Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.
Academic Article Attenuation of Fos-like immunoreactivity induced by a single electroconvulsive shock in brains of aging mice.
Academic Article Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins.
Academic Article Increased secretion of somatostatin-28 from hypothalamic neurons of aged rats in vitro.
Academic Article Diminished diurnal secretion of adrenocorticotropin (ACTH), but not corticosterone, in old male rats: possible relation to increased adrenal sensitivity to ACTH in vivo.
Academic Article Immunoreactive beta-endorphin in the plasma, pituitary and hypothalamus of young and old male rats.
Academic Article Immunoreactive beta-endorphin in the plasma, pituitary and hypothalamus of young female rats on the day of estrus and intact and chronically castrated old constant estrous female rats.
Academic Article Decreased ability of old male rats to secrete luteinizing hormone (LH) is not due to alterations in pituitary LH-releasing hormone receptors.
Academic Article Effects of ovariectomy and steroid replacement on hypothalamic LHRH content in aging female rats.
Academic Article Impaired ability of old male rats to secrete growth hormone in vivo but not in vitro in response to hpGRF(1-44).
Academic Article Effect of in utero ethanol exposure on the postnatal ontogeny of insulin-like growth factor-1, and type-1 and type-2 insulin-like growth factor receptors in the rat brain.
Academic Article Growth hormone-induced nuclear translocation of Stat-3 decreases with age: modulation by caloric restriction.
Academic Article Distribution and levels of insulin-like growth factor I mRNA across the life span in the Brown Norway x Fischer 344 rat brain.
Academic Article Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals.
Academic Article Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats.
Academic Article Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory.
Academic Article Assessment of physical function in aging rodents: a strategy for improving preclinical testing.
Academic Article Growth hormone reverses age-related cardiac myofilament dysfunction in rats.
Academic Article Growth hormone increases regional coronary blood flow and capillary density in aged rats.
Academic Article Somatostatin gene expression in hypothalamus and cortex of aging male rats.
Academic Article Effect of aging on GHRF-induced growth hormone release from anterior pituitary cells in primary culture.
Academic Article Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning.
Academic Article Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus.
Academic Article Lifelong caloric restriction and interleukin-6 secretion from adipose tissue: effects on physical performance decline in aged rats.
Academic Article Adult-onset deficiency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum.
Academic Article Cognitive performance and age-related changes in the hippocampal proteome.
Academic Article Mitochondria and aging in the vascular system.
Academic Article Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence.
Academic Article Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats.
Academic Article Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1.
Academic Article Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies.
Academic Article Insulin-like growth factor-1 in CNS and cerebrovascular aging.
Academic Article Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease.
Academic Article Positive Feedback by Ovarian Hormones on Prolactin and LH in Old Versus Young Female Rats.
Academic Article Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase.
Academic Article Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat.
Academic Article Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
Academic Article Aging impairs myogenic adaptation to pulsatile pressure in mouse cerebral arteries.
Academic Article IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging.
Academic Article Maintenance by L-DOPA treatment of estrous cycles and LH response to estrogen in aging female rats.
Academic Article Recent Developments in Understanding Brain Aging: Implications for Alzheimer's Disease and Vascular Cognitive Impairment.
Academic Article Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice.
Academic Article Effects of age and insulin-like growth factor-1 on rat neurotrophin receptor expression after nerve injury.
Academic Article Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice.
Academic Article GeroScience: understanding the interaction of processes of aging and chronic diseases.
Academic Article Reproduction in aging normal and neonatally androgenized female rats.
Academic Article Reduced ability of naloxone to stimulate LH and testosterone release in aging male rats; possible relation to increase in hypothalamic met5-enkephalin.
Academic Article Decreased pulsatile release of growth hormone in old male rats.
Academic Article Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging.
Academic Article Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency.
Academic Article Comparison of protein synthesis in brain and peripheral tissue during aging. Relationship to insulin-like growth factor-1 and type 1 IGF receptors.
Academic Article Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice.
Academic Article The regulation and mechanisms of action of growth hormone and insulin-like growth factor 1 during normal ageing.
Academic Article Insulin-like growth factor-1 ameliorates age-related behavioral deficits.
Academic Article Effect of age and caloric restriction on insulin receptor binding and glucose transporter levels in aging rats.
Academic Article Age-related synaptic changes in sensorimotor cortex of the Brown Norway X fischer 344 rat.
Academic Article Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease.
Academic Article Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis.
Academic Article Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus.
Academic Article Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging.
Academic Article Basal and hypercapnia-altered cerebrovascular perfusion predict mild cognitive impairment in aging rodents.
Academic Article Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Academic Article Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome.
Academic Article Aging attenuates radiation-induced expression of pro-inflammatory mediators in rat brain.
Academic Article Aging-related kidney damage is associated with a decrease in klotho expression and an increase in superoxide production.
Academic Article Mitochondrial protection by resveratrol.
Academic Article Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.
Academic Article Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?
Academic Article Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging.
Academic Article Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus.
Academic Article Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension.
Academic Article Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in ß-amyloid generation and Alzheimer's disease.
Academic Article A heart that beats for 500 years: age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in Arctica islandica, the longest-living noncolonial animal.
Academic Article IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice.
Academic Article Aging Exacerbates Pressure-Induced Mitochondrial Oxidative Stress in Mouse Cerebral Arteries.
Academic Article Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection.
Academic Article IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms.
Academic Article Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation.
Academic Article IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis.
Academic Article Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice.
Academic Article Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice.
Academic Article Growth hormone restores protein synthesis in skeletal muscle of old male rats.
Academic Article Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats.
Academic Article Caloric restriction decreases age-dependent accumulation of the glycoxidation products, N epsilon-(carboxymethyl)lysine and pentosidine, in rat skin collagen.
Academic Article Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats.
Academic Article Moderate caloric restriction alters the subcellular distribution of somatostatin mRNA and increases growth hormone pulse amplitude in aged animals.
Academic Article L-type Ca2+ channel-insulin-like growth factor-1 receptor signaling impairment in aging rat skeletal muscle.
Academic Article Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1.
Grant TNF ALPHA REG OF THE GROWTH HORMONE/IGF-1 AXIS WITH AGE
Grant Cognitive Decline &Protein Expression Profiles in Aging
Grant Biology of Aging Sessions at Meetings of The Gerontological Society of America
Grant TESTING THE ABILITY OF NOVEL ASSAYS OF RESILIENCE TO PREDICT LIFESPAN
Grant Effects of Radiation on Brain Microvasculature and Cognition
Grant NOVEL APPROACHES FOR REGULATION OF IGF-1 LEVELS THROUGHOUT THE LIFESPAN
Grant GROWTH HORMONE (GH) AND GH-DEPENDENT BIOMARKERS OF AGING
Grant Growth Hormone, IGF-1 and Age-related Pathogenesis
Grant Growth Hormone &IGF-1 in CNS and Cerebrovascular Aging
Grant REGULATION OF GROWTH HORMONE SECRETION IN AGING RATS
Grant Oklahoma Nathan Shock Center of Excellence in Basic Biology of Aging
Academic Article IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging.
Academic Article Oklahoma Nathan Shock Aging Center - assessing the basic biology of aging from genetics to protein and function.
Academic Article Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype.
Academic Article Increased Susceptibility to Cerebral Microhemorrhages Is Associated With Imaging Signs of Microvascular Degeneration in the Retina in an Insulin-Like Growth Factor 1 Deficient Mouse Model of Accelerated Aging.
Academic Article [The vascularisation of the granulation tissue in different ages. - Its importance for wound healing (author's transl)].
Academic Article [Polyploidisation - a phenomenon of aging? (author's transl)].
Academic Article Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment.
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