Item Type | Name |
Concept
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Aging
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Concept
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Cellular Senescence
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Academic Article
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Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression.
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Academic Article
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Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response.
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Academic Article
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Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.
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Academic Article
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Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging.
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Academic Article
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Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging.
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Academic Article
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Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging.
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Academic Article
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Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation-induced impairment of neurovascular coupling responses protecting cognitive function in mice.
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Academic Article
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Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation.
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Academic Article
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Age-related decline in peripheral vascular health predicts cognitive impairment.
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Academic Article
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Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research.
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Academic Article
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Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats.
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Academic Article
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Insulin-like growth factor-1 selectively increases glucose utilization in brains of aged animals.
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Academic Article
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The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing.
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Academic Article
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Insulin-like growth factor-1 does not ameliorate the age-related decline in presumptive inhibitory synapses in layer 2 of rat sensorimotor cortex.
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Academic Article
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Caloric restricted male rats demonstrate fewer synapses in layer 2 of sensorimotor cortex.
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Academic Article
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Microvascular plasticity in aging.
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Academic Article
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Of worms, flies, dwarfs, and things that go bump in the night.
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Academic Article
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Biomarkers of aging: from primitive organisms to humans.
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Academic Article
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Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems.
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Academic Article
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Dendritic stability in a model of adult-onset IGF-I deficiency.
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Academic Article
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Growth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin II expression in senescent rats.
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Academic Article
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Aging reduces hypoxia-induced microvascular growth in the rodent hippocampus.
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Academic Article
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Effects of short-term treadmill exercise training or growth hormone supplementation on diastolic function and exercise tolerance in old rats.
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Academic Article
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How age impairs the response of the neuromuscular junction to nerve transection and repair: An experimental study in rats.
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Academic Article
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Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation.
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Academic Article
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Impaired bladder function in aging male rats.
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Academic Article
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An assay for RNA oxidation induced abasic sites using the Aldehyde Reactive Probe.
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Academic Article
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Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animal.
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Academic Article
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Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory.
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Academic Article
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Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients.
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Academic Article
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Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
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Academic Article
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Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice.
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Academic Article
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Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats.
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Academic Article
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Growth hormone, insulin-like growth factor-1 and the aging brain.
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Academic Article
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Brain and cerebrovascular aging--new mechanisms and insights.
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Academic Article
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CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging.
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Academic Article
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Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging.
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Academic Article
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Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-ß uptake in astrocytes.
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Academic Article
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Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice.
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Academic Article
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Accelerated decline in cognition in a mouse model of increased oxidative stress.
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Academic Article
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Effects of aging and dietary restriction on tissue protein synthesis: relationship to plasma insulin-like growth factor-1.
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Academic Article
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Increased pituitary response to somatostatin in aging male rats: relationship to somatostatin receptor number and affinity.
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Academic Article
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Growth hormone releasing hormone induced release of growth hormone in aging male rats: dependence on pharmacological manipulation and endogenous somatostatin release.
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Academic Article
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Pituitary growth hormone and hypothalamic somatostatin in young female rats versus old constant estrous female rats.
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Academic Article
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Effects of CNS active drugs and somatostatin antiserum on growth hormone release in young and old male rats.
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Academic Article
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Decreases in growth hormone receptor signal transduction contribute to the decline in insulin-like growth factor I gene expression with age.
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Academic Article
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Moderate caloric restriction prevents the age-related decline in growth hormone receptor signal transduction.
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Academic Article
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Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood flow in aged rats.
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Academic Article
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Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determination.
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Academic Article
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Physical performance and longevity in aged rats.
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Academic Article
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A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan.
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Academic Article
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Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system.
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Academic Article
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Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus.
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Academic Article
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Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span.
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Academic Article
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Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability.
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Academic Article
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Growth hormone and aging: Regulation, signal transduction and replacement therapy.
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Academic Article
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Does senescence give rise to disease?
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Academic Article
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Mechanisms of vascular aging: new perspectives.
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Academic Article
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Age-related alterations in retinal neurovascular and inflammatory transcripts.
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Academic Article
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Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment.
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Academic Article
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Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats.
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Academic Article
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Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa).
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Academic Article
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Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosensitivity.
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Academic Article
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Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice.
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Academic Article
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Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats.
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Academic Article
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Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline.
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Academic Article
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Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.
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Academic Article
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Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.
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Academic Article
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Attenuation of Fos-like immunoreactivity induced by a single electroconvulsive shock in brains of aging mice.
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Academic Article
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Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins.
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Academic Article
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Increased secretion of somatostatin-28 from hypothalamic neurons of aged rats in vitro.
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Academic Article
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Diminished diurnal secretion of adrenocorticotropin (ACTH), but not corticosterone, in old male rats: possible relation to increased adrenal sensitivity to ACTH in vivo.
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Academic Article
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Immunoreactive beta-endorphin in the plasma, pituitary and hypothalamus of young and old male rats.
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Academic Article
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Immunoreactive beta-endorphin in the plasma, pituitary and hypothalamus of young female rats on the day of estrus and intact and chronically castrated old constant estrous female rats.
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Academic Article
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Decreased ability of old male rats to secrete luteinizing hormone (LH) is not due to alterations in pituitary LH-releasing hormone receptors.
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Academic Article
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Effects of ovariectomy and steroid replacement on hypothalamic LHRH content in aging female rats.
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Academic Article
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Impaired ability of old male rats to secrete growth hormone in vivo but not in vitro in response to hpGRF(1-44).
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Academic Article
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Effect of in utero ethanol exposure on the postnatal ontogeny of insulin-like growth factor-1, and type-1 and type-2 insulin-like growth factor receptors in the rat brain.
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Academic Article
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Growth hormone-induced nuclear translocation of Stat-3 decreases with age: modulation by caloric restriction.
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Academic Article
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Distribution and levels of insulin-like growth factor I mRNA across the life span in the Brown Norway x Fischer 344 rat brain.
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Academic Article
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Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals.
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Academic Article
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Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats.
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Academic Article
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Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory.
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Academic Article
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Assessment of physical function in aging rodents: a strategy for improving preclinical testing.
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Academic Article
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Growth hormone reverses age-related cardiac myofilament dysfunction in rats.
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Academic Article
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Growth hormone increases regional coronary blood flow and capillary density in aged rats.
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Academic Article
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Somatostatin gene expression in hypothalamus and cortex of aging male rats.
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Academic Article
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Effect of aging on GHRF-induced growth hormone release from anterior pituitary cells in primary culture.
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Academic Article
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Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning.
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Academic Article
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Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus.
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Academic Article
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Lifelong caloric restriction and interleukin-6 secretion from adipose tissue: effects on physical performance decline in aged rats.
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Academic Article
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Adult-onset deficiency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum.
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Academic Article
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Cognitive performance and age-related changes in the hippocampal proteome.
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Academic Article
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Mitochondria and aging in the vascular system.
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Academic Article
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Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence.
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Academic Article
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Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats.
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Academic Article
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Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1.
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Academic Article
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Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies.
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Academic Article
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Insulin-like growth factor-1 in CNS and cerebrovascular aging.
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Academic Article
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Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease.
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Academic Article
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Positive Feedback by Ovarian Hormones on Prolactin and LH in Old Versus Young Female Rats.
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Academic Article
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Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase.
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Academic Article
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Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat.
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Academic Article
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Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
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Academic Article
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Aging impairs myogenic adaptation to pulsatile pressure in mouse cerebral arteries.
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Academic Article
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IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging.
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Academic Article
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Maintenance by L-DOPA treatment of estrous cycles and LH response to estrogen in aging female rats.
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Academic Article
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Recent Developments in Understanding Brain Aging: Implications for Alzheimer's Disease and Vascular Cognitive Impairment.
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Academic Article
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Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice.
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Academic Article
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Effects of age and insulin-like growth factor-1 on rat neurotrophin receptor expression after nerve injury.
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Academic Article
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Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice.
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Academic Article
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GeroScience: understanding the interaction of processes of aging and chronic diseases.
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Academic Article
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Reproduction in aging normal and neonatally androgenized female rats.
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Academic Article
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Reduced ability of naloxone to stimulate LH and testosterone release in aging male rats; possible relation to increase in hypothalamic met5-enkephalin.
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Academic Article
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Decreased pulsatile release of growth hormone in old male rats.
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Academic Article
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Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging.
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Academic Article
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Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency.
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Academic Article
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Comparison of protein synthesis in brain and peripheral tissue during aging. Relationship to insulin-like growth factor-1 and type 1 IGF receptors.
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Academic Article
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Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice.
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Academic Article
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The regulation and mechanisms of action of growth hormone and insulin-like growth factor 1 during normal ageing.
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Academic Article
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Insulin-like growth factor-1 ameliorates age-related behavioral deficits.
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Academic Article
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Effect of age and caloric restriction on insulin receptor binding and glucose transporter levels in aging rats.
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Academic Article
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Age-related synaptic changes in sensorimotor cortex of the Brown Norway X fischer 344 rat.
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Academic Article
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Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease.
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Academic Article
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Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis.
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Academic Article
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Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus.
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Academic Article
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Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging.
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Academic Article
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Basal and hypercapnia-altered cerebrovascular perfusion predict mild cognitive impairment in aging rodents.
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Academic Article
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Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
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Academic Article
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Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome.
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Academic Article
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Aging attenuates radiation-induced expression of pro-inflammatory mediators in rat brain.
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Academic Article
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Aging-related kidney damage is associated with a decrease in klotho expression and an increase in superoxide production.
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Academic Article
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Mitochondrial protection by resveratrol.
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Academic Article
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Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.
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Academic Article
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Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?
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Academic Article
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Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging.
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Academic Article
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Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus.
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Academic Article
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Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension.
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Academic Article
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Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in ß-amyloid generation and Alzheimer's disease.
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Academic Article
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A heart that beats for 500 years: age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in Arctica islandica, the longest-living noncolonial animal.
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Academic Article
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IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice.
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Academic Article
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Aging Exacerbates Pressure-Induced Mitochondrial Oxidative Stress in Mouse Cerebral Arteries.
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Academic Article
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Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection.
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Academic Article
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IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms.
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Academic Article
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Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation.
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Academic Article
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IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis.
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Academic Article
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Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice.
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Academic Article
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Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice.
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Academic Article
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Growth hormone restores protein synthesis in skeletal muscle of old male rats.
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Academic Article
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Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats.
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Academic Article
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Caloric restriction decreases age-dependent accumulation of the glycoxidation products, N epsilon-(carboxymethyl)lysine and pentosidine, in rat skin collagen.
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Academic Article
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Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats.
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Academic Article
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Moderate caloric restriction alters the subcellular distribution of somatostatin mRNA and increases growth hormone pulse amplitude in aged animals.
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Academic Article
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L-type Ca2+ channel-insulin-like growth factor-1 receptor signaling impairment in aging rat skeletal muscle.
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Academic Article
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Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1.
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Grant
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TNF ALPHA REG OF THE GROWTH HORMONE/IGF-1 AXIS WITH AGE
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Grant
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Cognitive Decline &Protein Expression Profiles in Aging
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Grant
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Biology of Aging Sessions at Meetings of The Gerontological Society of America
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Grant
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TESTING THE ABILITY OF NOVEL ASSAYS OF RESILIENCE TO PREDICT LIFESPAN
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Grant
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Effects of Radiation on Brain Microvasculature and Cognition
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Grant
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NOVEL APPROACHES FOR REGULATION OF IGF-1 LEVELS THROUGHOUT THE LIFESPAN
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Grant
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GROWTH HORMONE (GH) AND GH-DEPENDENT BIOMARKERS OF AGING
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Grant
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Growth Hormone, IGF-1 and Age-related Pathogenesis
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Grant
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Growth Hormone &IGF-1 in CNS and Cerebrovascular Aging
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Grant
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REGULATION OF GROWTH HORMONE SECRETION IN AGING RATS
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Grant
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Oklahoma Nathan Shock Center of Excellence in Basic Biology of Aging
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Academic Article
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IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging.
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Academic Article
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Oklahoma Nathan Shock Aging Center - assessing the basic biology of aging from genetics to protein and function.
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Academic Article
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Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype.
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Academic Article
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Increased Susceptibility to Cerebral Microhemorrhages Is Associated With Imaging Signs of Microvascular Degeneration in the Retina in an Insulin-Like Growth Factor 1 Deficient Mouse Model of Accelerated Aging.
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Academic Article
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[The vascularisation of the granulation tissue in different ages. - Its importance for wound healing (author's transl)].
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Academic Article
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[Polyploidisation - a phenomenon of aging? (author's transl)].
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Academic Article
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Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment.
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