Item Type | Name |
Concept
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Insulin-Like Growth Factor I
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Concept
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Insulin-Like Growth Factor II
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Concept
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Receptors, Nerve Growth Factor
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Concept
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Transcription Factor AP-1
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Concept
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Insulin-Like Growth Factor Binding Proteins
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Concept
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Insulin-Like Growth Factor Binding Protein 1
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Concept
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Insulin-Like Growth Factor Binding Protein 2
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Concept
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Insulin-Like Growth Factor Binding Protein 3
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Concept
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Receptors, Tumor Necrosis Factor
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Concept
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Receptor, Nerve Growth Factor
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Concept
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NF-E2-Related Factor 2
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Concept
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Tumor Necrosis Factor-alpha
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Concept
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Vascular Endothelial Growth Factor Receptor-2
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Concept
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Vascular Endothelial Growth Factor A
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Concept
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STAT3 Transcription Factor
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Academic Article
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Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia.
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Academic Article
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Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression.
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Academic Article
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Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response.
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Academic Article
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Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.
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Academic Article
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Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging.
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Academic Article
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Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging.
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Academic Article
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Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging.
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Academic Article
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Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats.
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Academic Article
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Insulin-like growth factor-1 selectively increases glucose utilization in brains of aged animals.
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Academic Article
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The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing.
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Academic Article
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Insulin-like growth factor-1 does not ameliorate the age-related decline in presumptive inhibitory synapses in layer 2 of rat sensorimotor cortex.
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Academic Article
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Of worms, flies, dwarfs, and things that go bump in the night.
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Academic Article
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Dendritic stability in a model of adult-onset IGF-I deficiency.
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Academic Article
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Effects of short-term treadmill exercise training or growth hormone supplementation on diastolic function and exercise tolerance in old rats.
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Academic Article
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Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I.
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Academic Article
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Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation.
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Academic Article
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Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2.
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Academic Article
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Radiation attenuates physiological angiogenesis by differential expression of VEGF, Ang-1, tie-2 and Ang-2 in rat brain.
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Academic Article
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Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients.
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Academic Article
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Impaired vascular endothelial growth factor A and inflammation in patients with peripheral artery disease.
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Academic Article
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Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats.
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Academic Article
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Growth hormone, insulin-like growth factor-1 and the aging brain.
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Academic Article
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Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging.
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Academic Article
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Role of NADPH oxidase in radiation-induced pro-oxidative and pro-inflammatory pathways in mouse brain.
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Academic Article
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Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-ß uptake in astrocytes.
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Academic Article
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Effects of aging and dietary restriction on tissue protein synthesis: relationship to plasma insulin-like growth factor-1.
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Academic Article
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Diminished insulin-like growth factor-1 levels after chronic ethanol: relationship to pulsatile growth hormone release.
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Academic Article
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Decreases in growth hormone receptor signal transduction contribute to the decline in insulin-like growth factor I gene expression with age.
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Academic Article
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Long-term suppression of insulin-like growth factor-1 in rats after in utero ethanol exposure: relationship to somatic growth.
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Academic Article
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Moderate caloric restriction prevents the age-related decline in growth hormone receptor signal transduction.
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Academic Article
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Expression of insulin-like growth factor-1 (IGF-1) and IGF-binding protein 2 (IGF-BP2) in the hippocampus following cytotoxic lesion of the dentate gyrus.
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Academic Article
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Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determination.
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Academic Article
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A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan.
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Academic Article
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Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system.
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Academic Article
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Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus.
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Academic Article
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Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span.
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Academic Article
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Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints.
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Academic Article
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The ependymal route for insulin-like growth factor-1 gene therapy in the brain.
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Academic Article
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Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats.
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Academic Article
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Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.
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Academic Article
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Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats.
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Academic Article
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The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer.
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Academic Article
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Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.
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Academic Article
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Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.
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Academic Article
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Distribution of insulin-like growth factor 1 (IGF-1) and 2 (IGF-2) receptors in the hippocampal formation of rats and mice.
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Academic Article
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Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins.
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Academic Article
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Chronic ethanol feeding inhibits plasma levels of insulin-like growth factor-1.
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Academic Article
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Effect of in utero ethanol exposure on the postnatal ontogeny of insulin-like growth factor-1, and type-1 and type-2 insulin-like growth factor receptors in the rat brain.
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Academic Article
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Growth hormone-induced nuclear translocation of Stat-3 decreases with age: modulation by caloric restriction.
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Academic Article
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Distribution and levels of insulin-like growth factor I mRNA across the life span in the Brown Norway x Fischer 344 rat brain.
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Academic Article
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Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals.
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Academic Article
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Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats.
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Academic Article
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Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory.
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Academic Article
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Growth hormone increases regional coronary blood flow and capillary density in aged rats.
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Academic Article
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Growth hormone-deficient dwarf animals are resistant to dimethylbenzanthracine (DMBA)-induced mammary carcinogenesis.
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Academic Article
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Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning.
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Academic Article
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Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus.
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Academic Article
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Adult-onset deficiency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum.
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Academic Article
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Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain.
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Academic Article
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Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats.
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Academic Article
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Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence.
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Academic Article
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Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1.
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Academic Article
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Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies.
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Academic Article
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Increased hippocampal NgR1 signaling machinery in aged rats with deficits of spatial cognition.
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Academic Article
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Insulin-like growth factor-1 in CNS and cerebrovascular aging.
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Academic Article
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Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat.
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Academic Article
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Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
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Academic Article
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IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging.
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Academic Article
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Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice.
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Academic Article
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Effects of age and insulin-like growth factor-1 on rat neurotrophin receptor expression after nerve injury.
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Academic Article
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Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency.
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Academic Article
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Comparison of protein synthesis in brain and peripheral tissue during aging. Relationship to insulin-like growth factor-1 and type 1 IGF receptors.
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Academic Article
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The regulation and mechanisms of action of growth hormone and insulin-like growth factor 1 during normal ageing.
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Academic Article
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Insulin-like growth factor-1 ameliorates age-related behavioral deficits.
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Academic Article
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Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease.
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Academic Article
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Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis.
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Academic Article
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Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus.
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Academic Article
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Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus.
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Academic Article
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Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging.
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Academic Article
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Adult-onset deficiency in growth hormone and insulin-like growth factor-I decreases survival of dentate granule neurons: insights into the regulation of adult hippocampal neurogenesis.
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Academic Article
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Growth hormone and IGF-I modulate local cerebral glucose utilization and ATP levels in a model of adult-onset growth hormone deficiency.
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Academic Article
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Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
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Academic Article
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Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation.
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Academic Article
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Mitochondrial protection by resveratrol.
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Academic Article
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Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.
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Academic Article
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IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice.
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Academic Article
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IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms.
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Academic Article
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IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis.
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Academic Article
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IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan.
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Academic Article
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Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice.
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Academic Article
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Effect of ethanol on plasma and hepatic insulin-like growth factor regulation in pregnant rats.
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Academic Article
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Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats.
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Academic Article
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Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats.
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Academic Article
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Ethanol suppresses growth hormone-mediated cellular responses in liver slices.
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Academic Article
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L-type Ca2+ channel-insulin-like growth factor-1 receptor signaling impairment in aging rat skeletal muscle.
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Academic Article
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Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1.
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Grant
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TNF ALPHA REG OF THE GROWTH HORMONE/IGF-1 AXIS WITH AGE
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Grant
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CHRONIC ETHANOL AND INSULIN-LIKE GROWTH FACTORS
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Grant
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Growth Hormone, IGF-1 and Age-related Pathogenesis
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Academic Article
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Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype.
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Academic Article
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Increased Susceptibility to Cerebral Microhemorrhages Is Associated With Imaging Signs of Microvascular Degeneration in the Retina in an Insulin-Like Growth Factor 1 Deficient Mouse Model of Accelerated Aging.
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