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Concept
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Male
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Academic Article
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Cerebral microvascular rarefaction induced by whole brain radiation is reversible by systemic hypoxia in mice.
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Academic Article
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Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia.
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Academic Article
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Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression.
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Academic Article
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Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response.
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Academic Article
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Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.
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Academic Article
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Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging.
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Academic Article
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Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging.
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Academic Article
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Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation-induced impairment of neurovascular coupling responses protecting cognitive function in mice.
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Academic Article
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Age-related decline in peripheral vascular health predicts cognitive impairment.
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Academic Article
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Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research.
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Academic Article
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Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats.
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Academic Article
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Insulin-like growth factor-1 selectively increases glucose utilization in brains of aged animals.
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Academic Article
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Insulin-like growth factor-1 does not ameliorate the age-related decline in presumptive inhibitory synapses in layer 2 of rat sensorimotor cortex.
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Academic Article
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Caloric restricted male rats demonstrate fewer synapses in layer 2 of sensorimotor cortex.
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Academic Article
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Dendritic stability in a model of adult-onset IGF-I deficiency.
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Academic Article
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Effects of short-term treadmill exercise training or growth hormone supplementation on diastolic function and exercise tolerance in old rats.
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Academic Article
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How age impairs the response of the neuromuscular junction to nerve transection and repair: An experimental study in rats.
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Academic Article
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Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I.
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Academic Article
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Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation.
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Academic Article
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Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2.
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Academic Article
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Impaired bladder function in aging male rats.
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Academic Article
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Radiation attenuates physiological angiogenesis by differential expression of VEGF, Ang-1, tie-2 and Ang-2 in rat brain.
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Academic Article
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Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory.
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Academic Article
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Whole brain radiation-induced impairments in learning and memory are time-sensitive and reversible by systemic hypoxia.
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Academic Article
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Treatment with the cytochrome P450 ?-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats.
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Academic Article
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Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
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Academic Article
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Impaired vascular endothelial growth factor A and inflammation in patients with peripheral artery disease.
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Academic Article
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Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice.
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Academic Article
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Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats.
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Academic Article
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CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging.
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Academic Article
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Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging.
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Academic Article
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Role of NADPH oxidase in radiation-induced pro-oxidative and pro-inflammatory pathways in mouse brain.
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Academic Article
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Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice.
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Academic Article
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The effect of complete Freund--adjuvant on chronic proliferating inflammation in an experimental granuloma model.
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Academic Article
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Effects of aging and dietary restriction on tissue protein synthesis: relationship to plasma insulin-like growth factor-1.
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Academic Article
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Increased pituitary response to somatostatin in aging male rats: relationship to somatostatin receptor number and affinity.
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Academic Article
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Diminished insulin-like growth factor-1 levels after chronic ethanol: relationship to pulsatile growth hormone release.
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Academic Article
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Growth hormone releasing hormone induced release of growth hormone in aging male rats: dependence on pharmacological manipulation and endogenous somatostatin release.
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Academic Article
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Effects of CNS active drugs and somatostatin antiserum on growth hormone release in young and old male rats.
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Academic Article
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L-dopa restores amplitude of growth hormone pulses in old male rats to that observed in young male rats.
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Academic Article
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Cell fusion as a mechanism for the formation of giant cells (Langhans' type). Autoradiographic findings in autoimmune tubulo-interstitial nephritis of the rat.
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Academic Article
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Long-term suppression of insulin-like growth factor-1 in rats after in utero ethanol exposure: relationship to somatic growth.
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Academic Article
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Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood flow in aged rats.
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Academic Article
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Physical performance and longevity in aged rats.
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Academic Article
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Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus.
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Academic Article
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Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span.
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Academic Article
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Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints.
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Academic Article
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Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus.
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Academic Article
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Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability.
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Academic Article
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Age-related alterations in retinal neurovascular and inflammatory transcripts.
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Academic Article
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Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment.
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Academic Article
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Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats.
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Academic Article
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Irradiation alters MMP-2/TIMP-2 system and collagen type IV degradation in brain.
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Academic Article
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Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice.
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Academic Article
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Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats.
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Academic Article
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Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline.
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Academic Article
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Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice.
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Academic Article
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Systemic influences contribute to prolonged microvascular rarefaction after brain irradiation: a role for endothelial progenitor cells.
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Academic Article
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The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer.
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Academic Article
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Association between daily walking and antioxidant capacity in patients with symptomatic peripheral artery disease.
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Academic Article
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Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.
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Academic Article
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Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.
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Academic Article
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Distribution of insulin-like growth factor 1 (IGF-1) and 2 (IGF-2) receptors in the hippocampal formation of rats and mice.
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Academic Article
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Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins.
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Academic Article
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Increased secretion of somatostatin-28 from hypothalamic neurons of aged rats in vitro.
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Academic Article
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Effect of CNS-active drugs on TRH-induced prolactin release.
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Academic Article
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Mediation by gonadal steroids of plasma beta-endorphin and LH in castrated female and male rats.
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Academic Article
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Diminished diurnal secretion of adrenocorticotropin (ACTH), but not corticosterone, in old male rats: possible relation to increased adrenal sensitivity to ACTH in vivo.
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Academic Article
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Chronic ethanol feeding inhibits plasma levels of insulin-like growth factor-1.
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Academic Article
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Immunoreactive beta-endorphin in the plasma, pituitary and hypothalamus of young and old male rats.
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Academic Article
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Elevation of plasma LH in response to systemic injection of beta-endorphin antiserum in adult male rats.
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Academic Article
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Reduced ability of old male rats to release ACTH and corticosterone in response to CRF administration.
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Academic Article
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Decreased ability of old male rats to secrete luteinizing hormone (LH) is not due to alterations in pituitary LH-releasing hormone receptors.
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Academic Article
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Impaired ability of old male rats to secrete growth hormone in vivo but not in vitro in response to hpGRF(1-44).
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Academic Article
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Comparison of the effects of central acting drugs on prolactin release in young and old male rats.
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Academic Article
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Growth hormone-induced nuclear translocation of Stat-3 decreases with age: modulation by caloric restriction.
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Academic Article
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Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals.
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Academic Article
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Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats.
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Academic Article
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Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory.
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Academic Article
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Growth hormone reverses age-related cardiac myofilament dysfunction in rats.
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Academic Article
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Growth hormone increases regional coronary blood flow and capillary density in aged rats.
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Academic Article
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Somatostatin gene expression in hypothalamus and cortex of aging male rats.
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Academic Article
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Effect of aging on GHRF-induced growth hormone release from anterior pituitary cells in primary culture.
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Academic Article
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Lifelong caloric restriction and interleukin-6 secretion from adipose tissue: effects on physical performance decline in aged rats.
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Academic Article
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Adult-onset deficiency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum.
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Academic Article
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Cognitive performance and age-related changes in the hippocampal proteome.
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Academic Article
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Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain.
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Academic Article
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Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence.
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Academic Article
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Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats.
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Academic Article
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Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1.
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Academic Article
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Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies.
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Academic Article
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Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease.
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Academic Article
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Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase.
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Academic Article
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Gender and racial differences in endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease.
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Academic Article
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Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat.
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Academic Article
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Endothelial Cell Inflammation and Antioxidant Capacity are Associated With Exercise Performance and Microcirculation in Patients With Symptomatic Peripheral Artery Disease.
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Academic Article
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Aging impairs myogenic adaptation to pulsatile pressure in mouse cerebral arteries.
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Academic Article
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IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging.
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Academic Article
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Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice.
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Academic Article
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Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice.
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Academic Article
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Effects of age and insulin-like growth factor-1 on rat neurotrophin receptor expression after nerve injury.
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Academic Article
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Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice.
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Academic Article
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Reduced ability of naloxone to stimulate LH and testosterone release in aging male rats; possible relation to increase in hypothalamic met5-enkephalin.
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Academic Article
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Decreased pulsatile release of growth hormone in old male rats.
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Academic Article
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Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging.
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Academic Article
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Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency.
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Academic Article
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Comparison of protein synthesis in brain and peripheral tissue during aging. Relationship to insulin-like growth factor-1 and type 1 IGF receptors.
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Academic Article
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Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice.
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Academic Article
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Insulin-like growth factor-1 ameliorates age-related behavioral deficits.
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Academic Article
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Age-related synaptic changes in sensorimotor cortex of the Brown Norway X fischer 344 rat.
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Academic Article
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Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis.
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Academic Article
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Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus.
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Academic Article
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Angiotensin-converting enzyme inhibition, body composition, and physical performance in aged rats.
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Academic Article
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Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus.
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Academic Article
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Adult-onset deficiency in growth hormone and insulin-like growth factor-I decreases survival of dentate granule neurons: insights into the regulation of adult hippocampal neurogenesis.
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Academic Article
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Basal and hypercapnia-altered cerebrovascular perfusion predict mild cognitive impairment in aging rodents.
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Academic Article
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Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome.
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Academic Article
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Aging attenuates radiation-induced expression of pro-inflammatory mediators in rat brain.
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Academic Article
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Aging-related kidney damage is associated with a decrease in klotho expression and an increase in superoxide production.
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Academic Article
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Free radical production, antioxidant capacity, and oxidative stress response signatures in fibroblasts from Lewis dwarf rats: effects of life span-extending peripubertal GH treatment.
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Academic Article
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Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation.
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Academic Article
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Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline.
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Academic Article
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Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging.
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Academic Article
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Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus.
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Academic Article
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Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in ß-amyloid generation and Alzheimer's disease.
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Academic Article
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IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice.
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Academic Article
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Aging Exacerbates Pressure-Induced Mitochondrial Oxidative Stress in Mouse Cerebral Arteries.
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Academic Article
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Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection.
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Academic Article
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IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms.
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Academic Article
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IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan.
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Academic Article
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Endothelial Cell Inflammation and Antioxidant Capacity are Associated With 6-Minute Walk Performance in Patients With Symptomatic Peripheral Artery Disease.
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Academic Article
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Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice.
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Academic Article
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Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice.
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Academic Article
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The influence of D-penicillamine on cell proliferation. I. Quantitative investigations during an acute exudative inflammation in a model granuloma.
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Academic Article
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The influence of D-penicillamine on cell proliferation. II. Quantitative investigations during a chronic proliferative inflammation in a model granuloma.
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Academic Article
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Growth hormone restores protein synthesis in skeletal muscle of old male rats.
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Academic Article
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Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats.
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Academic Article
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Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats.
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Academic Article
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Moderate caloric restriction alters the subcellular distribution of somatostatin mRNA and increases growth hormone pulse amplitude in aged animals.
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Academic Article
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Ethanol suppresses growth hormone-mediated cellular responses in liver slices.
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Academic Article
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Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1.
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Grant
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REGULATION OF GROWTH HORMONE SECRETION IN AGING RATS
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Academic Article
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Sleep deprivation impairs cognitive performance, alters task-associated cerebral blood flow and decreases cortical neurovascular coupling-related hemodynamic responses.
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Academic Article
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Sleep deprivation alters task-related changes in functional connectivity of the frontal cortex: A near-infrared spectroscopy study.
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Academic Article
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[Polyploidisation - a phenomenon of aging? (author's transl)].
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Academic Article
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Decreased lifespan in female "Munchkin" actors from the cast of the 1939 film version of The Wizard of Oz does not support the hypothesis linking hypopituitary dwarfism to longevity.
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Academic Article
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Progressive cognitive impairment after recovery from neuroinvasive and non-neuroinvasive Listeria monocytogenes infection.
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