| Item Type | Name |
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Concept
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Rats, Inbred BN
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Concept
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Rats, Inbred F344
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Concept
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Rats, Inbred Lew
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Concept
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Rats, Inbred SHR
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Concept
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Rats, Inbred Strains
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Concept
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Rats, Inbred WKY
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Concept
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Rats, Mutant Strains
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Concept
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Rats, Sprague-Dawley
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Concept
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Rats
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Academic Article
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Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response.
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Academic Article
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Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging.
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Academic Article
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Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research.
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Academic Article
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Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats.
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Academic Article
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Insulin-like growth factor-1 selectively increases glucose utilization in brains of aged animals.
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Academic Article
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The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing.
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Academic Article
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Insulin-like growth factor-1 does not ameliorate the age-related decline in presumptive inhibitory synapses in layer 2 of rat sensorimotor cortex.
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Academic Article
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Caloric restricted male rats demonstrate fewer synapses in layer 2 of sensorimotor cortex.
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Academic Article
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Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems.
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Academic Article
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Dendritic stability in a model of adult-onset IGF-I deficiency.
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Academic Article
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Growth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin II expression in senescent rats.
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Academic Article
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Aging reduces hypoxia-induced microvascular growth in the rodent hippocampus.
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Academic Article
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Effects of short-term treadmill exercise training or growth hormone supplementation on diastolic function and exercise tolerance in old rats.
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Academic Article
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How age impairs the response of the neuromuscular junction to nerve transection and repair: An experimental study in rats.
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Academic Article
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Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I.
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Academic Article
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Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation.
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Academic Article
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Impaired bladder function in aging male rats.
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Academic Article
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Radiation attenuates physiological angiogenesis by differential expression of VEGF, Ang-1, tie-2 and Ang-2 in rat brain.
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Academic Article
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Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory.
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Academic Article
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Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients.
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Academic Article
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Treatment with the cytochrome P450 ?-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats.
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Academic Article
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Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
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Academic Article
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Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats.
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Academic Article
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Growth hormone, insulin-like growth factor-1 and the aging brain.
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Academic Article
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The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A.
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Academic Article
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The effect of complete Freund--adjuvant on chronic proliferating inflammation in an experimental granuloma model.
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Academic Article
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Increased pituitary response to somatostatin in aging male rats: relationship to somatostatin receptor number and affinity.
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Academic Article
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Diminished insulin-like growth factor-1 levels after chronic ethanol: relationship to pulsatile growth hormone release.
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Academic Article
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Growth hormone releasing hormone induced release of growth hormone in aging male rats: dependence on pharmacological manipulation and endogenous somatostatin release.
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Academic Article
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Pituitary growth hormone and hypothalamic somatostatin in young female rats versus old constant estrous female rats.
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Academic Article
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Effects of CNS active drugs and somatostatin antiserum on growth hormone release in young and old male rats.
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Academic Article
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L-dopa restores amplitude of growth hormone pulses in old male rats to that observed in young male rats.
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Academic Article
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Cell fusion as a mechanism for the formation of giant cells (Langhans' type). Autoradiographic findings in autoimmune tubulo-interstitial nephritis of the rat.
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Academic Article
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Long-term suppression of insulin-like growth factor-1 in rats after in utero ethanol exposure: relationship to somatic growth.
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Academic Article
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Expression of insulin-like growth factor-1 (IGF-1) and IGF-binding protein 2 (IGF-BP2) in the hippocampus following cytotoxic lesion of the dentate gyrus.
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Academic Article
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Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood flow in aged rats.
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Academic Article
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Physical performance and longevity in aged rats.
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Academic Article
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A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan.
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Academic Article
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Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system.
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Academic Article
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Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus.
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Academic Article
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Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span.
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Academic Article
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Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints.
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Academic Article
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Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus.
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Academic Article
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Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability.
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Academic Article
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The ependymal route for insulin-like growth factor-1 gene therapy in the brain.
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Academic Article
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Age-related alterations in retinal neurovascular and inflammatory transcripts.
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Academic Article
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Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment.
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Academic Article
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Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats.
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Academic Article
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Irradiation alters MMP-2/TIMP-2 system and collagen type IV degradation in brain.
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Academic Article
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Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosensitivity.
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Academic Article
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Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats.
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Academic Article
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Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline.
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Academic Article
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The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer.
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Academic Article
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Distribution of insulin-like growth factor 1 (IGF-1) and 2 (IGF-2) receptors in the hippocampal formation of rats and mice.
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Academic Article
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Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins.
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Academic Article
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Increased secretion of somatostatin-28 from hypothalamic neurons of aged rats in vitro.
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Academic Article
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Effect of CNS-active drugs on TRH-induced prolactin release.
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Academic Article
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Mediation by gonadal steroids of plasma beta-endorphin and LH in castrated female and male rats.
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Academic Article
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Diminished diurnal secretion of adrenocorticotropin (ACTH), but not corticosterone, in old male rats: possible relation to increased adrenal sensitivity to ACTH in vivo.
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Academic Article
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Chronic ethanol feeding inhibits plasma levels of insulin-like growth factor-1.
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Academic Article
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Immunoreactive beta-endorphin in the plasma, pituitary and hypothalamus of young and old male rats.
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Academic Article
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Elevation of plasma LH in response to systemic injection of beta-endorphin antiserum in adult male rats.
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Academic Article
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Immunoreactive beta-endorphin in the plasma, pituitary and hypothalamus of young female rats on the day of estrus and intact and chronically castrated old constant estrous female rats.
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Academic Article
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Reduced ability of old male rats to release ACTH and corticosterone in response to CRF administration.
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Academic Article
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Decreased ability of old male rats to secrete luteinizing hormone (LH) is not due to alterations in pituitary LH-releasing hormone receptors.
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Academic Article
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Effects of ovariectomy and steroid replacement on hypothalamic LHRH content in aging female rats.
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Academic Article
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Impaired ability of old male rats to secrete growth hormone in vivo but not in vitro in response to hpGRF(1-44).
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Academic Article
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Comparison of the effects of central acting drugs on prolactin release in young and old male rats.
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Academic Article
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Effect of in utero ethanol exposure on the postnatal ontogeny of insulin-like growth factor-1, and type-1 and type-2 insulin-like growth factor receptors in the rat brain.
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Academic Article
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Distribution and levels of insulin-like growth factor I mRNA across the life span in the Brown Norway x Fischer 344 rat brain.
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Academic Article
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Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats.
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Academic Article
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Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory.
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Academic Article
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Assessment of physical function in aging rodents: a strategy for improving preclinical testing.
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Academic Article
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Growth hormone reverses age-related cardiac myofilament dysfunction in rats.
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Academic Article
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Growth hormone increases regional coronary blood flow and capillary density in aged rats.
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Academic Article
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Somatostatin gene expression in hypothalamus and cortex of aging male rats.
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Academic Article
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Growth hormone-deficient dwarf animals are resistant to dimethylbenzanthracine (DMBA)-induced mammary carcinogenesis.
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Academic Article
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Effect of aging on GHRF-induced growth hormone release from anterior pituitary cells in primary culture.
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Academic Article
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Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning.
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Academic Article
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Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus.
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Academic Article
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Lifelong caloric restriction and interleukin-6 secretion from adipose tissue: effects on physical performance decline in aged rats.
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Academic Article
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Adult-onset deficiency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum.
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Academic Article
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Cognitive performance and age-related changes in the hippocampal proteome.
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Academic Article
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Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain.
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Academic Article
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Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats.
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Academic Article
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Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence.
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Academic Article
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Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats.
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Academic Article
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Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1.
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Academic Article
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Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies.
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Academic Article
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Increased hippocampal NgR1 signaling machinery in aged rats with deficits of spatial cognition.
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Academic Article
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Positive Feedback by Ovarian Hormones on Prolactin and LH in Old Versus Young Female Rats.
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Academic Article
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Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat.
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Academic Article
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Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
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Academic Article
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Maintenance by L-DOPA treatment of estrous cycles and LH response to estrogen in aging female rats.
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Academic Article
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Suppression by naloxone of rise in plasma growth hormone and prolactin induced by sucking.
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Academic Article
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Effects of age and insulin-like growth factor-1 on rat neurotrophin receptor expression after nerve injury.
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Academic Article
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Reproduction in aging normal and neonatally androgenized female rats.
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Academic Article
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Reduced ability of naloxone to stimulate LH and testosterone release in aging male rats; possible relation to increase in hypothalamic met5-enkephalin.
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Academic Article
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Decreased pulsatile release of growth hormone in old male rats.
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Academic Article
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Comparison of protein synthesis in brain and peripheral tissue during aging. Relationship to insulin-like growth factor-1 and type 1 IGF receptors.
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Academic Article
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The regulation and mechanisms of action of growth hormone and insulin-like growth factor 1 during normal ageing.
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Academic Article
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Insulin-like growth factor-1 ameliorates age-related behavioral deficits.
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Academic Article
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Effect of age and caloric restriction on insulin receptor binding and glucose transporter levels in aging rats.
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Academic Article
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Chronic caloric restriction alters muscle membrane fatty acid content.
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Academic Article
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Age-related synaptic changes in sensorimotor cortex of the Brown Norway X fischer 344 rat.
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Academic Article
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Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis.
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Academic Article
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Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus.
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Academic Article
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Angiotensin-converting enzyme inhibition, body composition, and physical performance in aged rats.
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Academic Article
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Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus.
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Academic Article
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Adult-onset deficiency in growth hormone and insulin-like growth factor-I decreases survival of dentate granule neurons: insights into the regulation of adult hippocampal neurogenesis.
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Academic Article
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Growth hormone and IGF-I modulate local cerebral glucose utilization and ATP levels in a model of adult-onset growth hormone deficiency.
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Academic Article
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Basal and hypercapnia-altered cerebrovascular perfusion predict mild cognitive impairment in aging rodents.
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Academic Article
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Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
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Academic Article
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Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome.
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Academic Article
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Aging attenuates radiation-induced expression of pro-inflammatory mediators in rat brain.
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Academic Article
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Aging-related kidney damage is associated with a decrease in klotho expression and an increase in superoxide production.
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Academic Article
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Free radical production, antioxidant capacity, and oxidative stress response signatures in fibroblasts from Lewis dwarf rats: effects of life span-extending peripubertal GH treatment.
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Academic Article
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Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation.
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Academic Article
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Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline.
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Academic Article
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Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging.
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Academic Article
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Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus.
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Academic Article
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Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation.
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Academic Article
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The influence of D-penicillamine on cell proliferation. I. Quantitative investigations during an acute exudative inflammation in a model granuloma.
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Academic Article
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The influence of D-penicillamine on cell proliferation. II. Quantitative investigations during a chronic proliferative inflammation in a model granuloma.
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Academic Article
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Growth hormone restores protein synthesis in skeletal muscle of old male rats.
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Academic Article
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Effect of ethanol on plasma and hepatic insulin-like growth factor regulation in pregnant rats.
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Academic Article
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Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats.
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Academic Article
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Caloric restriction decreases age-dependent accumulation of the glycoxidation products, N epsilon-(carboxymethyl)lysine and pentosidine, in rat skin collagen.
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Academic Article
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Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats.
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Academic Article
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Moderate caloric restriction alters the subcellular distribution of somatostatin mRNA and increases growth hormone pulse amplitude in aged animals.
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Academic Article
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Ethanol suppresses growth hormone-mediated cellular responses in liver slices.
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Academic Article
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L-type Ca2+ channel-insulin-like growth factor-1 receptor signaling impairment in aging rat skeletal muscle.
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Academic Article
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Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1.
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Grant
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GROWTH HORMONE (GH) AND GH-DEPENDENT BIOMARKERS OF AGING
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Grant
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REGULATION OF GROWTH HORMONE SECRETION IN AGING RATS
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Grant
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CHRONIC ETHANOL, GROWTH HORMONE AND PROTEIN SYNTHESIS
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Academic Article
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[The vascularisation of the granulation tissue in different ages. - Its importance for wound healing (author's transl)].
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Academic Article
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[Polyploidisation - a phenomenon of aging? (author's transl)].
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