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Vitamin A Deficiency
RPE65 gene delivery restores isomerohydrolase activity and prevents early cone loss in Rpe65-/- mice.
Comparison of ocular pathologies in vitamin A-deficient mice and RPE65 gene knockout mice.
Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane.
RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle.
An alternative isomerohydrolase in the retinal Müller cells of a cone-dominant species.
Identification of the key residues determining the product specificity of isomerohydrolase.
A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration.