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Ungvari, Zoltan
One or more keywords matched the following items that are connected to Ungvari, Zoltan
Item TypeName
Concept Cognitive Aging
Concept Aging
Concept Cellular Senescence
Concept Healthy Aging
Academic Article Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression.
Academic Article Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response.
Academic Article Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.
Academic Article Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging.
Academic Article Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging.
Academic Article Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging.
Academic Article Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline.
Academic Article Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation.
Academic Article Assessment of age-related decline of neurovascular coupling responses by functional near-infrared spectroscopy (fNIRS) in humans.
Academic Article Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging.
Academic Article Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation-induced impairment of neurovascular coupling responses protecting cognitive function in mice.
Academic Article Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain.
Academic Article Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation.
Academic Article Obesity-induced cognitive impairment in older adults: a microvascular perspective.
Academic Article Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment.
Academic Article Role of endothelial NAD+ deficiency in age-related vascular dysfunction.
Academic Article Age-related decline in peripheral vascular health predicts cognitive impairment.
Academic Article Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research.
Academic Article Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment.
Academic Article Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects.
Academic Article Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseases.
Academic Article Vascular inflammation in aging.
Academic Article Comparison of endothelial function, O2-* and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice.
Academic Article Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats.
Academic Article Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging.
Academic Article Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency.
Academic Article Comparative gerontology--from mussels to man.
Academic Article Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animal.
Academic Article Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients.
Academic Article Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
Academic Article Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice.
Academic Article Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats.
Academic Article Brain and cerebrovascular aging--new mechanisms and insights.
Academic Article Pharmacological Strategies to Retard Cardiovascular Aging.
Academic Article Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging.
Academic Article Connective tissue growth factor (CTGF) in age-related vascular pathologies.
Academic Article Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice.
Academic Article Endothelial dysfunction and angiogenesis impairment in the ageing vasculature.
Academic Article Age-related impairment of neurovascular coupling responses: a dynamic vessel analysis (DVA)-based approach to measure decreased flicker light stimulus-induced retinal arteriolar dilation in healthy older adults.
Academic Article Overexpression of catalase targeted to mitochondria improves neurovascular coupling responses in aged mice.
Academic Article Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function.
Academic Article Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries.
Academic Article Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen.
Academic Article Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging.
Academic Article Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1.
Academic Article Mechanisms of vascular aging: new perspectives.
Academic Article The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances.
Academic Article Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa).
Academic Article Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus.
Academic Article Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosensitivity.
Academic Article Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice.
Academic Article Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats.
Academic Article Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging.
Academic Article Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.
Academic Article Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence.
Academic Article Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies.
Academic Article Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.
Academic Article IGF-1 Deficiency Promotes Pathological Remodeling of Cerebral Arteries: A Potential Mechanism Contributing to the Pathogenesis of Intracerebral Hemorrhages in Aging.
Academic Article Mechanisms of Vascular Aging.
Academic Article Age-Related Alterations in Gait Function in Freely Moving Male C57BL/6 Mice: Translational Relevance of Decreased Cadence and Increased Gait Variability.
Academic Article Mechanisms of Vascular Aging, A Geroscience Perspective: JACC Focus Seminar.
Academic Article Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging.
Academic Article Altered mitochondrial energy metabolism may play a role in vascular aging.
Academic Article Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity.
Academic Article Oxidative stress in vascular senescence: lessons from successfully aging species.
Academic Article Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
Academic Article Inflammation and endothelial dysfunction during aging: role of NF-kappaB.
Academic Article Consequences of intraventricular hemorrhage in a rabbit pup model.
Academic Article Mitochondria and aging in the vascular system.
Academic Article Mitochondria and cardiovascular aging.
Academic Article Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies.
Academic Article Insulin-like growth factor-1 in CNS and cerebrovascular aging.
Academic Article Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease.
Academic Article Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase.
Academic Article Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat.
Academic Article Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
Academic Article Aging impairs myogenic adaptation to pulsatile pressure in mouse cerebral arteries.
Academic Article IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging.
Academic Article Recent Developments in Understanding Brain Aging: Implications for Alzheimer's Disease and Vascular Cognitive Impairment.
Academic Article Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline.
Academic Article GeroScience: understanding the interaction of processes of aging and chronic diseases.
Academic Article Cerebral microhemorrhages: mechanisms, consequences, and prevention.
Academic Article Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment.
Academic Article Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency.
Academic Article Microvascular contributions to age-related macular degeneration (AMD): from mechanisms of choriocapillaris aging to novel interventions.
Academic Article Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging.
Academic Article Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries.
Academic Article The aging kidney: role of endothelial oxidative stress and inflammation.
Academic Article Vascular aging in the longest-living rodent, the naked mole rat.
Academic Article Oxidative stress and accelerated vascular aging: implications for cigarette smoking.
Academic Article Mitochondrial protection by resveratrol.
Academic Article Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.
Academic Article Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?
Academic Article Are sirtuins viable targets for improving healthspan and lifespan?
Academic Article Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension.
Academic Article Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in ß-amyloid generation and Alzheimer's disease.
Academic Article A heart that beats for 500 years: age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in Arctica islandica, the longest-living noncolonial animal.
Academic Article IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice.
Academic Article Aging Exacerbates Pressure-Induced Mitochondrial Oxidative Stress in Mouse Cerebral Arteries.
Academic Article Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection.
Academic Article IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms.
Academic Article Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet.
Academic Article IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis.
Academic Article Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass.
Academic Article Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice.
Academic Article Advances and challenges in geroscience research: An update.
Academic Article Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice.
Grant Age-related vascular cognitive impairment: role of endothelial senescence
Grant Cerebral microhemorrhages and gait dysfunction in aging
Grant Role of SIRT1 in vasoprotection
Grant Radiation-induced astrocyte dysfunction and cognitive decline
Academic Article IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging.
Academic Article Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by longitudinal intravital two-photon microscopy and optical coherence tomography.
Academic Article The future of healthy aging: translation of geroscience discoveries to public health practice.
Academic Article Endothelial Dysfunction and Impaired Neurovascular Coupling Responses Precede Cognitive Impairment in a Mouse Model of Geriatric Sepsis.
Grant Cerebromicrovascular rejuvenation by heterochronic blood exchange
Academic Article Effect of genetic depletion of MMP-9 on neurological manifestations of hypertension-induced intracerebral hemorrhages in aged mice.
Academic Article Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice.
Academic Article The Effect of Mild Traumatic Brain Injury on Cerebral Microbleeds in Aging.
Academic Article Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype.
Academic Article Microvascular dysfunction and neurovascular uncoupling are exacerbated in peripheral artery disease, increasing the risk of cognitive decline in older adults.
Academic Article Increased Susceptibility to Cerebral Microhemorrhages Is Associated With Imaging Signs of Microvascular Degeneration in the Retina in an Insulin-Like Growth Factor 1 Deficient Mouse Model of Accelerated Aging.
Academic Article Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain.
Academic Article Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling.
Academic Article Urinary Biomarkers of Oxidative Stress in Aging: Implications for Prediction of Accelerated Biological Age in Prospective Cohort Studies.
Academic Article The multifaceted benefits of walking for healthy aging: from Blue Zones to molecular mechanisms.
Academic Article The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging.
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  • Aging