Item Type | Name |
Concept
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Animals
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Concept
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Animals, Newborn
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Concept
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Behavior, Animal
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Concept
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Lameness, Animal
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Concept
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Models, Animal
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Concept
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Disease Models, Animal
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Academic Article
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Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia.
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Academic Article
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Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression.
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Academic Article
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Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response.
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Academic Article
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Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.
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Academic Article
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Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging.
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Academic Article
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Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging.
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Academic Article
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Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline.
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Academic Article
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Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation.
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Academic Article
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Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging.
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Academic Article
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Cerebral venous congestion promotes blood-brain barrier disruption and neuroinflammation, impairing cognitive function in mice.
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Academic Article
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Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation-induced impairment of neurovascular coupling responses protecting cognitive function in mice.
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Academic Article
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Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects.
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Academic Article
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Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood.
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Academic Article
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Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain.
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Academic Article
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Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation.
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Academic Article
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Obesity-induced cognitive impairment in older adults: a microvascular perspective.
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Academic Article
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Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment.
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Academic Article
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Role of endothelial NAD+ deficiency in age-related vascular dysfunction.
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Academic Article
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Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research.
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Academic Article
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Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment.
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Academic Article
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Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects.
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Academic Article
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Fusogenic liposomes effectively deliver resveratrol to the cerebral microcirculation and improve endothelium-dependent neurovascular coupling responses in aged mice.
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Academic Article
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Speculations on difference between tricyclic and selective serotonin reuptake inhibitor antidepressants on their cardiac effects. Is there any?
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Academic Article
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Electrophysiological effects of homocysteine in isolated rat right ventricular papillary muscles and left atria.
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Academic Article
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Endothelin and prostaglandin H(2)/thromboxane A(2) enhance myogenic constriction in hypertension by increasing Ca(2+) sensitivity of arteriolar smooth muscle.
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Academic Article
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Flow-induced constriction in arterioles of hyperhomocysteinemic rats is due to impaired nitric oxide and enhanced thromboxane A(2) mediation.
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Academic Article
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Increases in endothelial Ca(2+) activate K(Ca) channels and elicit EDHF-type arteriolar dilation via gap junctions.
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Academic Article
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Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase.
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Academic Article
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Chronic high pressure-induced arterial oxidative stress: involvement of protein kinase C-dependent NAD(P)H oxidase and local renin-angiotensin system.
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Academic Article
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Vascular inflammation in aging.
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Academic Article
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Comparison of endothelial function, O2-* and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice.
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Academic Article
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Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasone.
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Academic Article
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Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction.
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Academic Article
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Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats.
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Academic Article
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Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging.
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Academic Article
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Oxidative-nitrosative stress in a rabbit pup model of germinal matrix hemorrhage: role of NAD(P)H oxidase.
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Academic Article
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Effect of hyperoxic resuscitation on propensity of germinal matrix haemorrhage and cerebral injury.
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Academic Article
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Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2.
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Academic Article
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Intramyocardial VEGF-B167 gene delivery delays the progression towards congestive failure in dogs with pacing-induced dilated cardiomyopathy.
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Academic Article
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Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibition.
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Academic Article
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Comparative gerontology--from mussels to man.
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Academic Article
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Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animal.
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Academic Article
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Novel organotypic in vitro slice culture model for intraventricular hemorrhage of premature infants.
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Academic Article
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Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients.
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Academic Article
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Treatment with the cytochrome P450 ?-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats.
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Academic Article
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Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
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Academic Article
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Role of mitochondrial oxidative stress in hypertension.
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Academic Article
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Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.
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Academic Article
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Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice.
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Academic Article
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Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats.
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Academic Article
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Brain and cerebrovascular aging--new mechanisms and insights.
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Academic Article
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Pharmacological Strategies to Retard Cardiovascular Aging.
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Academic Article
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Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging.
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Academic Article
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Traumatic brain injury-induced autoregulatory dysfunction and spreading depression-related neurovascular uncoupling: Pathomechanisms, perspectives, and therapeutic implications.
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Academic Article
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Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment.
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Academic Article
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Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice.
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Academic Article
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Endothelial dysfunction and angiogenesis impairment in the ageing vasculature.
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Academic Article
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Overexpression of catalase targeted to mitochondria improves neurovascular coupling responses in aged mice.
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Academic Article
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Serotonin reuptake inhibitor, fluoxetine, dilates isolated skeletal muscle arterioles. Possible role of altered Ca2+ sensitivity.
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Academic Article
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Dysfunction of nitric oxide mediation in isolated rat arterioles with methionine diet-induced hyperhomocysteinemia.
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Academic Article
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Fluoxetine dilates isolated small cerebral arteries of rats and attenuates constrictions to serotonin, norepinephrine, and a voltage-dependent Ca(2+) channel opener.
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Academic Article
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Homocysteine reduces smooth muscle [Ca2+]i and constrictor responses of isolated arterioles.
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Academic Article
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Selected contribution: NO released to flow reduces myogenic tone of skeletal muscle arterioles by decreasing smooth muscle Ca(2+) sensitivity.
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Academic Article
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Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function.
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Academic Article
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Impaired nitric oxide-mediated flow-induced coronary dilation in hyperhomocysteinemia: morphological and functional evidence for increased peroxynitrite formation.
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Academic Article
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Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries.
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Academic Article
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Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging.
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Academic Article
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Cigarette smoke-induced proinflammatory alterations in the endothelial phenotype: role of NAD(P)H oxidase activation.
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Academic Article
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Resveratrol increases vascular oxidative stress resistance.
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Academic Article
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CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion.
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Academic Article
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Endothelium-derived bone morphogenic protein antagonists may counteract the proatherogenic vascular effects of bone morphogenic protein 4.
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Academic Article
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Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations.
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Academic Article
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Resveratrol induces mitochondrial biogenesis in endothelial cells.
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Academic Article
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Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress.
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Academic Article
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Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1.
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Academic Article
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Mechanisms of vascular aging: new perspectives.
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Academic Article
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Effect of prenatal glucocorticoids on cerebral vasculature of the developing brain.
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Academic Article
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SRT1720 improves survival and healthspan of obese mice.
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Academic Article
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The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances.
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Academic Article
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Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa).
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Academic Article
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Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.
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Academic Article
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Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus.
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Academic Article
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Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosensitivity.
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Academic Article
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Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice.
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Academic Article
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Whole brain radiation-induced vascular cognitive impairment: mechanisms and implications.
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Academic Article
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Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats.
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Academic Article
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Systemic influences contribute to prolonged microvascular rarefaction after brain irradiation: a role for endothelial progenitor cells.
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Academic Article
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Purinergic glio-endothelial coupling during neuronal activity: role of P2Y1 receptors and eNOS in functional hyperemia in the mouse somatosensory cortex.
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Academic Article
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Biotin-conjugated fusogenic liposomes for high-quality cell purification.
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Academic Article
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The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer.
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Academic Article
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Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.
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Academic Article
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Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence.
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Academic Article
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Why publish in the American Journal of Physiology-Heart and Circulatory Physiology?
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Academic Article
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Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.
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Academic Article
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IGF-1 Deficiency Promotes Pathological Remodeling of Cerebral Arteries: A Potential Mechanism Contributing to the Pathogenesis of Intracerebral Hemorrhages in Aging.
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Academic Article
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Glycogen synthase kinase-3ß inhibition enhances myelination in preterm newborns with intraventricular hemorrhage, but not recombinant Wnt3A.
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Academic Article
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Mechanisms of Vascular Aging.
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Academic Article
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Age-Related Alterations in Gait Function in Freely Moving Male C57BL/6 Mice: Translational Relevance of Decreased Cadence and Increased Gait Variability.
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Academic Article
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Single Mild Traumatic Brain Injury Induces Persistent Disruption of the Blood-Brain Barrier, Neuroinflammation and Cognitive Decline in Hypertensive Rats.
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Academic Article
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Hypertension Exacerbates Cerebrovascular Oxidative Stress Induced by Mild Traumatic Brain Injury: Protective Effects of the Mitochondria-Targeted Antioxidative Peptide SS-31.
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Academic Article
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CD82-TRPM7-Numb signaling mediates age-related cognitive impairment.
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Academic Article
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Mechanisms of Vascular Aging, A Geroscience Perspective: JACC Focus Seminar.
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Academic Article
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Increased myogenic tone in skeletal muscle arterioles of diabetic rats. Possible role of increased activity of smooth muscle Ca2+ channels and protein kinase C.
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Academic Article
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Simultaneously increased TxA(2) activity in isolated arterioles and platelets of rats with hyperhomocysteinemia.
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Academic Article
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Role of endothelial [Ca2+]i in activation of eNOS in pressurized arterioles by agonists and wall shear stress.
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Academic Article
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Serotonin reuptake inhibitors fluoxetine and citalopram relax intestinal smooth muscle.
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Academic Article
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Mediation of EDHF-induced reduction of smooth muscle [Ca(2+)](i) and arteriolar dilation by K(+) channels, 5,6-EET, and gap junctions.
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Academic Article
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Increased NO-mediated and reduced TxA2-dependent responses in skeletal muscle arterioles in pregnancy.
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Academic Article
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High pressure induces superoxide production in isolated arteries via protein kinase C-dependent activation of NAD(P)H oxidase.
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Academic Article
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Pentose phosphate pathway coordinates multiple redox-controlled relaxing mechanisms in bovine coronary arteries.
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Academic Article
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Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging.
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Academic Article
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Synergistic effects of vascular IL-17 and TNFalpha may promote coronary artery disease.
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Academic Article
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Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure.
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Academic Article
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Altered mitochondrial energy metabolism may play a role in vascular aging.
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Academic Article
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Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: role of shear stress and the cAMP/protein kinase A pathway.
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Academic Article
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Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity.
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Academic Article
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Paucity of pericytes in germinal matrix vasculature of premature infants.
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Academic Article
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Oxidative stress in vascular senescence: lessons from successfully aging species.
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Academic Article
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Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells.
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Academic Article
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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
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Academic Article
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Endothelial dysfunction and vascular inflammation in type 2 diabetes: interaction of AGE/RAGE and TNF-alpha signaling.
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Academic Article
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Inflammation and endothelial dysfunction during aging: role of NF-kappaB.
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Academic Article
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The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach.
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Academic Article
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Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopus.
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Academic Article
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Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats.
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Academic Article
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Consequences of intraventricular hemorrhage in a rabbit pup model.
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Academic Article
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Role of NAD(P)H oxidase in superoxide generation and endothelial dysfunction in Goto-Kakizaki (GK) rats as a model of nonobese NIDDM.
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Academic Article
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Resveratrol improves left ventricular diastolic relaxation in type 2 diabetes by inhibiting oxidative/nitrative stress: in vivo demonstration with magnetic resonance imaging.
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Academic Article
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Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats.
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Academic Article
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Mitochondria and cardiovascular aging.
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Academic Article
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Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies.
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Academic Article
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Resistance to genotoxic stresses in Arctica islandica, the longest living noncolonial animal: is extreme longevity associated with a multistress resistance phenotype?
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Academic Article
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Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease.
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Academic Article
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Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase.
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Academic Article
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Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat.
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Academic Article
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Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
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Academic Article
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Aging impairs myogenic adaptation to pulsatile pressure in mouse cerebral arteries.
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Academic Article
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IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging.
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Academic Article
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Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice.
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Academic Article
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AMPA-Kainate Receptor Inhibition Promotes Neurologic Recovery in Premature Rabbits with Intraventricular Hemorrhage.
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Academic Article
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Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline.
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Academic Article
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Cerebral microhemorrhages: mechanisms, consequences, and prevention.
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Academic Article
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Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency.
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Academic Article
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Age-dependent cardiovascular effects of sepsis in a murine model of cecal ligation and puncture: implications for the design of interventional studies.
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Academic Article
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Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice.
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Academic Article
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Whole brain irradiation in mice causes long-term impairment in astrocytic calcium signaling but preserves astrocyte-astrocyte coupling.
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Academic Article
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Review of cardiovascular effects of fluoxetine, a selective serotonin reuptake inhibitor, compared to tricyclic antidepressants.
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Academic Article
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Serotonin reuptake inhibitor fluoxetine decreases arteriolar myogenic tone by reducing smooth muscle [Ca2+]i.
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Academic Article
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Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite.
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Academic Article
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Different roles of PKC and MAP kinases in arteriolar constrictions to pressure and agonists.
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Academic Article
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Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging.
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Academic Article
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Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype.
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Academic Article
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Mechanosensitive production of reactive oxygen species in endothelial and smooth muscle cells: role in microvascular remodeling?
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Academic Article
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Angiogenic inhibition reduces germinal matrix hemorrhage.
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Academic Article
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Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries.
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Academic Article
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The aging kidney: role of endothelial oxidative stress and inflammation.
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Academic Article
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Vascular aging in the longest-living rodent, the naked mole rat.
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Academic Article
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Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice.
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Academic Article
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Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver.
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Academic Article
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Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expression.
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Academic Article
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Caveolin-1 limits the contribution of BK(Ca) channel to EDHF-mediated arteriolar dilation: implications in diet-induced obesity.
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Academic Article
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Resveratrol confers endothelial protection in insulin-dependent diabetes mellitus: editorial to: "Resveratrol shows vasoprotective effect reducing oxidative stress without affecting metabolic disturbances in insulin-dependent diabetes of rabbits" by F. Akar et al.
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Academic Article
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Free radical production, antioxidant capacity, and oxidative stress response signatures in fibroblasts from Lewis dwarf rats: effects of life span-extending peripubertal GH treatment.
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Academic Article
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Mitochondrial protection by resveratrol.
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Academic Article
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Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.
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Academic Article
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Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?
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Academic Article
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Are sirtuins viable targets for improving healthspan and lifespan?
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Academic Article
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Intraventricular hemorrhage induces deposition of proteoglycans in premature rabbits, but their in vivo degradation with chondroitinase does not restore myelination, ventricle size and neurological recovery.
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Academic Article
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Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension.
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Academic Article
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Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in ß-amyloid generation and Alzheimer's disease.
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Academic Article
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A heart that beats for 500 years: age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in Arctica islandica, the longest-living noncolonial animal.
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Academic Article
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Beneficial effects of acute inhibition of the oxidative pentose phosphate pathway in the failing heart.
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Academic Article
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IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice.
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Academic Article
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Aging Exacerbates Pressure-Induced Mitochondrial Oxidative Stress in Mouse Cerebral Arteries.
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Academic Article
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Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection.
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Academic Article
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IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms.
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Academic Article
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Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet.
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Academic Article
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IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis.
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Academic Article
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IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan.
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Academic Article
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Age-related impairment of metabovascular coupling during cortical spreading depolarizations.
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Academic Article
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Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice.
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Academic Article
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Disruption of Interneuron Neurogenesis in Premature Newborns and Reversal with Estrogen Treatment.
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Academic Article
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Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass.
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Academic Article
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Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice.
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Academic Article
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Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice.
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Academic Article
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Companion animals likely do not spread COVID-19 but may get infected themselves.
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Academic Article
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Increases in hypertension-induced cerebral microhemorrhages exacerbate gait dysfunction in a mouse model of Alzheimer's disease.
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Academic Article
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Midlife Obesity Impairs Neurovascular Coupling Responses.
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Grant
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Role of SIRT1 in vasoprotection
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Grant
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Hemodynamic forces regulate BMPs in coronary arteries
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Academic Article
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IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging.
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Academic Article
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Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by longitudinal intravital two-photon microscopy and optical coherence tomography.
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Academic Article
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Effect of genetic depletion of MMP-9 on neurological manifestations of hypertension-induced intracerebral hemorrhages in aged mice.
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Academic Article
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Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice.
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Academic Article
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Early manifestation of gait alterations in the Tg2576 mouse model of Alzheimer's disease.
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Academic Article
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Animal reservoirs of SARS-CoV-2: calculable COVID-19 risk for older adults from animal to human transmission.
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Academic Article
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Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype.
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Academic Article
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Cerebral venous congestion exacerbates cerebral microhemorrhages in mice.
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Academic Article
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Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain.
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Academic Article
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Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling.
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