| Item Type | Name |
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Concept
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Concept
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Interleukin-6
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Concept
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Sirtuins
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Concept
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Sirtuin 1
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Concept
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Sirtuin 3
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Academic Article
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Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation-induced impairment of neurovascular coupling responses protecting cognitive function in mice.
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Academic Article
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Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects.
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Academic Article
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Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood.
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Academic Article
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Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain.
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Academic Article
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Obesity-induced cognitive impairment in older adults: a microvascular perspective.
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Academic Article
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Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations.
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Academic Article
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Resveratrol induces mitochondrial biogenesis in endothelial cells.
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Academic Article
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Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1.
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Academic Article
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Prostaglandin E2, a postulated mediator of neurovascular coupling, at low concentrations dilates whereas at higher concentrations constricts human cerebral parenchymal arterioles.
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Academic Article
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CD82-TRPM7-Numb signaling mediates age-related cognitive impairment.
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Academic Article
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Mechanisms of Vascular Aging, A Geroscience Perspective: JACC Focus Seminar.
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Academic Article
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Traumatic brain injury-induced cerebral microbleeds in the elderly.
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Academic Article
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Retinal biomarkers for Alzheimer's disease and vascular cognitive impairment and dementia (VCID): implication for early diagnosis and prognosis.
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Academic Article
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Heterochronic blood exchange attenuates age-related neuroinflammation and confers cognitive benefits: do microvascular protective effects play a role?
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Academic Article
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Whole brain irradiation in mice causes long-term impairment in astrocytic calcium signaling but preserves astrocyte-astrocyte coupling.
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Academic Article
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Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells.
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Academic Article
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Caveolin-1 limits the contribution of BK(Ca) channel to EDHF-mediated arteriolar dilation: implications in diet-induced obesity.
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Academic Article
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Mitochondrial protection by resveratrol.
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Academic Article
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Are sirtuins viable targets for improving healthspan and lifespan?
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Academic Article
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Companion animals likely do not spread COVID-19 but may get infected themselves.
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Academic Article
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Increases in hypertension-induced cerebral microhemorrhages exacerbate gait dysfunction in a mouse model of Alzheimer's disease.
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Academic Article
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Midlife Obesity Impairs Neurovascular Coupling Responses.
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Academic Article
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IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging.
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Academic Article
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Effect of Growth Hormone on Neuropsychological Outcomes and Quality of Life of Patients with Traumatic Brain Injury: A Systematic Review.
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Academic Article
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Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by longitudinal intravital two-photon microscopy and optical coherence tomography.
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Academic Article
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The future of healthy aging: translation of geroscience discoveries to public health practice.
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Academic Article
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Increased cognitive workload evokes greater neurovascular coupling responses in healthy young adults.
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Academic Article
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Endothelial Dysfunction and Impaired Neurovascular Coupling Responses Precede Cognitive Impairment in a Mouse Model of Geriatric Sepsis.
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Academic Article
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Effect of genetic depletion of MMP-9 on neurological manifestations of hypertension-induced intracerebral hemorrhages in aged mice.
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Academic Article
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Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice.
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Academic Article
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Expanding the horizon of research into the pathogenesis of the white matter diseases: Proceedings of the 2021 Annual Workshop of the Albert Research Institute for White Matter and Cognition.
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Academic Article
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Sleep deprivation impairs cognitive performance, alters task-associated cerebral blood flow and decreases cortical neurovascular coupling-related hemodynamic responses.
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Academic Article
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Hypertension-induced cognitive impairment: from pathophysiology to public health.
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Academic Article
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Sleep deprivation alters task-related changes in functional connectivity of the frontal cortex: A near-infrared spectroscopy study.
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Academic Article
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Early manifestation of gait alterations in the Tg2576 mouse model of Alzheimer's disease.
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Academic Article
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Animal reservoirs of SARS-CoV-2: calculable COVID-19 risk for older adults from animal to human transmission.
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Academic Article
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The Effect of Mild Traumatic Brain Injury on Cerebral Microbleeds in Aging.
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Academic Article
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Cognitive decrement in older adults with symptomatic peripheral artery disease.
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Academic Article
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Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype.
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Academic Article
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Microvascular dysfunction and neurovascular uncoupling are exacerbated in peripheral artery disease, increasing the risk of cognitive decline in older adults.
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Academic Article
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Increased Susceptibility to Cerebral Microhemorrhages Is Associated With Imaging Signs of Microvascular Degeneration in the Retina in an Insulin-Like Growth Factor 1 Deficient Mouse Model of Accelerated Aging.
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Academic Article
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Cerebral venous congestion exacerbates cerebral microhemorrhages in mice.
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Academic Article
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Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain.
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Academic Article
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Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling.
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Academic Article
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Urinary Biomarkers of Oxidative Stress in Aging: Implications for Prediction of Accelerated Biological Age in Prospective Cohort Studies.
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Academic Article
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Stringent public health measures during COVID-19 across ischemic stroke care systems: the potential impact of patient perceptions on health care-seeking behaviors.
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Academic Article
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Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults.
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Academic Article
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The multifaceted benefits of walking for healthy aging: from Blue Zones to molecular mechanisms.
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Academic Article
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The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging.
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