| Item Type | Name |
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Concept
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Cognitive Aging
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Concept
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Aging
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Concept
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Cellular Senescence
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Academic Article
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Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline.
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Academic Article
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Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation.
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Academic Article
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Assessment of age-related decline of neurovascular coupling responses by functional near-infrared spectroscopy (fNIRS) in humans.
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Academic Article
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Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging.
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Academic Article
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Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation-induced impairment of neurovascular coupling responses protecting cognitive function in mice.
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Academic Article
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Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain.
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Academic Article
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Obesity-induced cognitive impairment in older adults: a microvascular perspective.
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Academic Article
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Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment.
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Academic Article
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Role of endothelial NAD+ deficiency in age-related vascular dysfunction.
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Academic Article
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Age-related decline in peripheral vascular health predicts cognitive impairment.
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Academic Article
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Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research.
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Academic Article
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Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment.
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Academic Article
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Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects.
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Academic Article
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Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseases.
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Academic Article
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Connective tissue growth factor (CTGF) in age-related vascular pathologies.
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Academic Article
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Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice.
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Academic Article
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Age-related impairment of neurovascular coupling responses: a dynamic vessel analysis (DVA)-based approach to measure decreased flicker light stimulus-induced retinal arteriolar dilation in healthy older adults.
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Academic Article
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Is Testosterone Replacement Therapy in Older Men Effective and Safe?
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Academic Article
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Overexpression of catalase targeted to mitochondria improves neurovascular coupling responses in aged mice.
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Academic Article
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Cardiac aging is initiated by matrix metalloproteinase-9-mediated endothelial dysfunction.
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Academic Article
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Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.
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Academic Article
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Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence.
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Academic Article
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Macrophage overexpression of matrix metalloproteinase-9 in aged mice improves diastolic physiology and cardiac wound healing after myocardial infarction.
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Academic Article
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Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.
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Academic Article
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IGF-1 Deficiency Promotes Pathological Remodeling of Cerebral Arteries: A Potential Mechanism Contributing to the Pathogenesis of Intracerebral Hemorrhages in Aging.
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Academic Article
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Age-Related Alterations in Gait Function in Freely Moving Male C57BL/6 Mice: Translational Relevance of Decreased Cadence and Increased Gait Variability.
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Academic Article
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Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence.
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Academic Article
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Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice.
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Academic Article
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Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment.
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Academic Article
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Microvascular contributions to age-related macular degeneration (AMD): from mechanisms of choriocapillaris aging to novel interventions.
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Academic Article
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Age-related alterations in the cerebrovasculature affect neurovascular coupling and BOLD fMRI responses: Insights from animal models of aging.
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Academic Article
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Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization.
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Academic Article
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Transgenic overexpression of macrophage matrix metalloproteinase-9 exacerbates age-related cardiac hypertrophy, vessel rarefaction, inflammation, and fibrosis.
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Academic Article
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Advances and challenges in geroscience research: An update.
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Academic Article
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Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice.
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Academic Article
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IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging.
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Academic Article
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Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by longitudinal intravital two-photon microscopy and optical coherence tomography.
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Academic Article
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Endothelial Dysfunction and Impaired Neurovascular Coupling Responses Precede Cognitive Impairment in a Mouse Model of Geriatric Sepsis.
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Academic Article
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Effect of genetic depletion of MMP-9 on neurological manifestations of hypertension-induced intracerebral hemorrhages in aged mice.
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Academic Article
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Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice.
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Academic Article
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Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype.
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Academic Article
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Microvascular dysfunction and neurovascular uncoupling are exacerbated in peripheral artery disease, increasing the risk of cognitive decline in older adults.
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Academic Article
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Increased Susceptibility to Cerebral Microhemorrhages Is Associated With Imaging Signs of Microvascular Degeneration in the Retina in an Insulin-Like Growth Factor 1 Deficient Mouse Model of Accelerated Aging.
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Academic Article
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Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain.
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Academic Article
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Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling.
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Academic Article
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Urinary Biomarkers of Oxidative Stress in Aging: Implications for Prediction of Accelerated Biological Age in Prospective Cohort Studies.
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Academic Article
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Sex-specific hippocampal connectivity markers in mild cognitive impairment.
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Academic Article
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Revisiting adipose thermogenesis for delaying aging and age-related diseases: Opportunities and challenges.
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Academic Article
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Gait variability predicts cognitive impairment in older adults with subclinical cerebral small vessel disease.
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Academic Article
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Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment.
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Academic Article
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Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)-induced chemobrain.
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Academic Article
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Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures.
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Academic Article
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Beyond the aging spine - a systematic review of functional changes in the human brain in cervical spondylotic myelopathy.
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Academic Article
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The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment.
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Academic Article
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Preventing spontaneous cerebral microhemorrhages in aging mice: a novel approach targeting cellular senescence with ABT263/navitoclax.
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Academic Article
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The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging.
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Academic Article
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Endothelial deficiency of insulin-like growth factor-1 receptor leads to blood-brain barrier disruption and accelerated endothelial senescence in mice, mimicking aspects of the brain aging phenotype.
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Academic Article
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PCSK9: an emerging player in cardiometabolic aging and its potential as a therapeutic target and biomarker.
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Academic Article
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Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence.
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