Item Type | Name |
Concept
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Oxidative Stress
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Academic Article
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Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response.
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Academic Article
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Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.
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Academic Article
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Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging.
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Academic Article
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Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging.
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Academic Article
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Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging.
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Academic Article
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Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline.
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Academic Article
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Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood.
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Academic Article
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Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation.
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Academic Article
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Role of endothelial NAD+ deficiency in age-related vascular dysfunction.
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Academic Article
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Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment.
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Academic Article
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Fusogenic liposomes effectively deliver resveratrol to the cerebral microcirculation and improve endothelium-dependent neurovascular coupling responses in aged mice.
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Academic Article
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Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseases.
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Academic Article
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Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase.
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Academic Article
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Chronic high pressure-induced arterial oxidative stress: involvement of protein kinase C-dependent NAD(P)H oxidase and local renin-angiotensin system.
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Academic Article
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Vascular inflammation in aging.
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Academic Article
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Comparison of endothelial function, O2-* and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice.
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Academic Article
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Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats.
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Academic Article
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Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging.
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Academic Article
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Oxidative-nitrosative stress in a rabbit pup model of germinal matrix hemorrhage: role of NAD(P)H oxidase.
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Academic Article
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Effect of hyperoxic resuscitation on propensity of germinal matrix haemorrhage and cerebral injury.
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Academic Article
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Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2.
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Academic Article
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Intramyocardial VEGF-B167 gene delivery delays the progression towards congestive failure in dogs with pacing-induced dilated cardiomyopathy.
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Academic Article
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Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animal.
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Academic Article
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Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients.
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Academic Article
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Treatment with the cytochrome P450 ?-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats.
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Academic Article
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Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
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Academic Article
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Impaired vascular endothelial growth factor A and inflammation in patients with peripheral artery disease.
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Academic Article
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Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice.
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Academic Article
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Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats.
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Academic Article
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Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function.
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Academic Article
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Oxidative stress-induced isoprostane formation may contribute to aspirin resistance in platelets.
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Academic Article
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Resveratrol increases vascular oxidative stress resistance.
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Academic Article
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Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations.
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Academic Article
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Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1.
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Academic Article
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Oxidative stress and endothelial dysfunction in pulmonary arteries of aged rats.
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Academic Article
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Mechanisms of vascular aging: new perspectives.
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Academic Article
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Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa).
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Academic Article
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Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosensitivity.
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Academic Article
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Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics.
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Academic Article
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Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats.
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Academic Article
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Greater endothelial apoptosis and oxidative stress in patients with peripheral artery disease.
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Academic Article
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Association between gait characteristics and endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease.
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Academic Article
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Association between daily walking and antioxidant capacity in patients with symptomatic peripheral artery disease.
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Academic Article
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Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.
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Academic Article
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Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.
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Academic Article
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Mechanisms of Vascular Aging.
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Academic Article
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Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity.
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Academic Article
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Oxidative stress in vascular senescence: lessons from successfully aging species.
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Academic Article
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Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells.
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Academic Article
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Inflammation and endothelial dysfunction during aging: role of NF-kappaB.
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Academic Article
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The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach.
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Academic Article
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Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopus.
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Academic Article
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Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats.
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Academic Article
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Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats.
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Academic Article
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Mitochondria and aging in the vascular system.
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Academic Article
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Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease.
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Academic Article
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Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease.
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Academic Article
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Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase.
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Academic Article
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Gender and racial differences in endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease.
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Academic Article
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Endothelial Cell Inflammation and Antioxidant Capacity are Associated With Exercise Performance and Microcirculation in Patients With Symptomatic Peripheral Artery Disease.
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Academic Article
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Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline.
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Academic Article
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Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice.
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Academic Article
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Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype.
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Academic Article
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The aging kidney: role of endothelial oxidative stress and inflammation.
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Academic Article
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Vascular aging in the longest-living rodent, the naked mole rat.
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Academic Article
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Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice.
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Academic Article
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Oxidative stress and accelerated vascular aging: implications for cigarette smoking.
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Academic Article
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Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expression.
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Academic Article
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Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells.
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Academic Article
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Resveratrol confers endothelial protection in insulin-dependent diabetes mellitus: editorial to: "Resveratrol shows vasoprotective effect reducing oxidative stress without affecting metabolic disturbances in insulin-dependent diabetes of rabbits" by F. Akar et al.
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Academic Article
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Free radical production, antioxidant capacity, and oxidative stress response signatures in fibroblasts from Lewis dwarf rats: effects of life span-extending peripubertal GH treatment.
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Academic Article
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Mitochondrial protection by resveratrol.
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Academic Article
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Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.
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Academic Article
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Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?
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Academic Article
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A heart that beats for 500 years: age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in Arctica islandica, the longest-living noncolonial animal.
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Academic Article
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Aging Exacerbates Pressure-Induced Mitochondrial Oxidative Stress in Mouse Cerebral Arteries.
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Academic Article
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Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection.
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Academic Article
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Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet.
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Academic Article
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IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis.
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Academic Article
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Endothelial Cell Inflammation and Antioxidant Capacity are Associated With 6-Minute Walk Performance in Patients With Symptomatic Peripheral Artery Disease.
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Academic Article
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Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass.
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Grant
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Vasoprotection by Caloric Restriction Mimetics in Aging
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Grant
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Microvascular mechanisms of neuroinflammation: role of Nrf2
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Grant
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Cerebromicrovascular rejuvenation by heterochronic blood exchange
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Academic Article
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Urinary Biomarkers of Oxidative Stress in Aging: Implications for Prediction of Accelerated Biological Age in Prospective Cohort Studies.
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