| Item Type | Name |
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Concept
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Protein Domains
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Concept
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Protein Engineering
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Concept
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Protein Structure, Secondary
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Concept
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Protein Structure, Tertiary
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Concept
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Protein Folding
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Concept
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Protein Structure, Quaternary
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Concept
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Receptors, G-Protein-Coupled
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Concept
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Protein Isoforms
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Concept
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Parathyroid Hormone-Related Protein
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Concept
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Protein Binding
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Concept
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Protein Conformation
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Concept
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Protein Kinases
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Concept
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Protein Processing, Post-Translational
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Concept
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Ubiquitin-Protein Ligases
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Concept
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Protein Multimerization
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Concept
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Structural Homology, Protein
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Concept
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Protein Interaction Domains and Motifs
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Concept
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Receptor Activity-Modifying Protein 1
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Concept
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Receptor Activity-Modifying Protein 2
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Concept
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Receptor Activity-Modifying Protein 3
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Concept
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Calcitonin Receptor-Like Protein
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Concept
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Wnt3 Protein
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Academic Article
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The Escherichia coli PII signal transduction protein regulates the activities of the two-component system transmitter protein NRII by direct interaction with the kinase domain of the transmitter module.
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Academic Article
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Genetic and biochemical analysis of phosphatase activity of Escherichia coli NRII (NtrB) and its regulation by the PII signal transduction protein.
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Academic Article
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Structures of a putative RNA 5-methyluridine methyltransferase, Thermus thermophilus TTHA1280, and its complex with S-adenosyl-L-homocysteine.
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Academic Article
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Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1.
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Academic Article
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Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor.
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Academic Article
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Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli.
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Academic Article
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Structural insights into ligand recognition and selectivity for classes A, B, and C GPCRs.
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Academic Article
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Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.
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Academic Article
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Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists.
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Academic Article
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Calcitonin Receptor N-Glycosylation Enhances Peptide Hormone Affinity by Controlling Receptor Dynamics.
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Academic Article
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RAMPs as allosteric modulators of the calcitonin and calcitonin-like class B G protein-coupled receptors.
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Academic Article
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Biochemical characterization of G protein coupling to calcitonin gene-related peptide and adrenomedullin receptors using a native PAGE assay.
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Academic Article
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Mutations altering the N-terminal receiver domain of NRI (NtrC) That prevent dephosphorylation by the NRII-PII complex in Escherichia coli.
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Academic Article
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Molecular recognition of parathyroid hormone by its G protein-coupled receptor.
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Academic Article
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Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors.
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Academic Article
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Bacterial expression and purification of a heterodimeric adrenomedullin receptor extracellular domain complex using DsbC-assisted disulfide shuffling.
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Academic Article
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Selective CGRP and adrenomedullin peptide binding by tethered RAMP-calcitonin receptor-like receptor extracellular domain fusion proteins.
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Academic Article
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N-Glycosylation of Asparagine 130 in the Extracellular Domain of the Human Calcitonin Receptor Significantly Increases Peptide Hormone Affinity.
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Academic Article
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Mechanism of the PII-activated phosphatase activity of Escherichia coli NRII (NtrB): how the different domains of NRII collaborate to act as a phosphatase.
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Academic Article
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Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides.
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Academic Article
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Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation.
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Academic Article
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Engineering high-potency R-spondin adult stem cell growth factors.
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Academic Article
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Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles.
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Academic Article
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Calcitonin and Amylin Receptor Peptide Interaction Mechanisms: INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS.
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Academic Article
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Molecular interaction of an antagonistic amylin analog with the extracellular domain of receptor activity-modifying protein 2 assessed by fluorescence polarization.
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Academic Article
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Crystal structure of the C-terminal domain of the two-component system transmitter protein nitrogen regulator II (NRII; NtrB), regulator of nitrogen assimilation in Escherichia coli.
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Academic Article
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Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties.
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Academic Article
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Structure-function analyses reveal a triple ß-turn receptor-bound conformation of adrenomedullin 2/intermedin and enable peptide antagonist design.
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Grant
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RAMP-altered class B GPCR hormone binding and signaling
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Academic Article
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A Native PAGE Assay for the Biochemical Characterization of G Protein Coupling to GPCRs.
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Academic Article
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Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin 2 G protein-coupled receptor.
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Academic Article
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Time- and cost-efficient bacterial expression and purification of potato apyrase.
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Academic Article
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Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin2 G protein-coupled receptor.
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