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Cook, Paul

One or more keywords matched the following items that are connected to Cook, Paul

Item Type	Name
Concept	Ascaris suum
Concept	Ascaris
Academic Article	Alpha-secondary tritium kinetic isotope effects indicate hydrogen tunneling and coupled motion occur in the oxidation of L-malate by NAD-malic enzyme.
Academic Article	Kinetic characterization of a T-state of Ascaris suum phosphofructokinase with heterotropic negative cooperativity by ATP eliminated.
Academic Article	Optimum activity of the phosphofructokinase from Ascaris suum requires more than one metal ion.
Academic Article	Proper positioning of the nicotinamide ring is crucial for the Ascaris suum malic enzyme reaction.
Academic Article	Mechanism of activation of the NAD-malic enzyme from Ascaris suum by fumarate.
Academic Article	Substrate activation by malate induced by oxalate in the Ascaris suum NAD-malic enzyme reaction.
Academic Article	Acid-base catalytic mechanism and pH dependence of fructose 2,6-bisphosphate activation of the Ascaris suum phosphofructokinase.
Academic Article	Isotope partitioning with Ascaris suum phosphofructokinase is consistent with an ordered kinetic mechanism.
Academic Article	Comparison of the substrate specificities of cAMP-dependent protein kinase from bovine heart and Ascaris suum muscle.
Academic Article	Mapping the active site topography of the NAD-malic enzyme via alanine-scanning site-directed mutagenesis.
Academic Article	Crystal structure of the malic enzyme from Ascaris suum complexed with nicotinamide adenine dinucleotide at 2.3 A resolution.
Academic Article	A catalytic triad is responsible for acid-base chemistry in the Ascaris suum NAD-malic enzyme.
Academic Article	Crystallization of the NAD-dependent malic enzyme from the parasitic nematode Ascaris suum.
Academic Article	Effector-induced conformational transitions in Ascaris suum phosphofructokinase. A fluorescence and circular dichroism study.
Academic Article	Fructose 2,6-bisphosphate and AMP increase the affinity of the Ascaris suum phosphofructokinase for fructose 6-phosphate in a process separate from the relief of ATP inhibition.
Academic Article	Modification of the ATP inhibitory site of the Ascaris suum phosphofructokinase results in the stabilization of an inactive T state.
Academic Article	Correlation between hysteresis and allosteric properties for phosphofructokinase from Ascaris suum.
Academic Article	Reaction of Ascaris suum phosphofructokinase with diethylpyrocarbonate. Inactivation and desensitization to allosteric modulation.
Academic Article	Kinetic mechanism of Ascaris suum phosphofructokinase desensitized to allosteric modulation by diethylpyrocarbonate modification.
Academic Article	Kinetic mechanism in the direction of oxidative decarboxylation for NAD-malic enzyme from Ascaris suum.
Academic Article	Determination of dissociation constants for enzyme-reactant complexes for NAD-malic enzyme by modulation of the thiol inactivation rate.
Academic Article	Metal ion activator effects on intrinsic isotope effects for hydride transfer from decarboxylation in the reaction catalyzed by the NAD-malic enzyme from Ascaris suum.
Academic Article	Role of the divalent metal ion in the NAD:malic enzyme reaction: an ESEEM determination of the ground state conformation of malate in the E:Mn:malate complex.
Academic Article	Kinetic mechanism of NAD:malic enzyme from Ascaris suum in the direction of reductive carboxylation.
Academic Article	Crystallographic studies on Ascaris suum NAD-malic enzyme bound to reduced cofactor and identification of an effector site.
Academic Article	Ascaris suum NAD-malic enzyme is activated by L-malate and fumarate binding to separate allosteric sites.
Academic Article	Multiple isotope effects with alternative dinucleotide substrates as a probe of the malic enzyme reaction.
Academic Article	Modification of a thiol at the active site of the Ascaris suum NAD-malic enzyme results in changes in the rate-determining steps for oxidative decarboxylation of L-malate.
Academic Article	Isotope partitioning for NAD-malic enzyme from Ascaris suum confirms a steady-state random kinetic mechanism.
Academic Article	Protonation mechanism and location of rate-determining steps for the Ascaris suum nicotinamide adenine dinucleotide-malic enzyme reaction from isotope effects and pH studies.
Academic Article	Modification of an arginine residue essential for the activity of NAD-malic enzyme from Ascaris suum.
Academic Article	Stepwise versus concerted oxidative decarboxylation catalyzed by malic enzyme: a reinvestigation.
Academic Article	Lysine 199 is the general acid in the NAD-malic enzyme reaction.
Academic Article	Multiple roles of arginine 181 in binding and catalysis in the NAD-malic enzyme from Ascaris suum.
Academic Article	Role of residues in the adenosine binding site of NAD of the Ascaris suum malic enzyme.
Academic Article	pH dependence of kinetic parameters for oxalacetate decarboxylation and pyruvate reduction reactions catalyzed by malic enzyme.
Academic Article	Diethylpyrocarbonate inactivation of NAD-malic enzyme from Ascaris suum.
Academic Article	A pH-dependent allosteric transition in Ascaris suum phosphofructokinase distinct from that observed with fructose 2,6-bisphosphate.
Academic Article	Cloning and nucleotide sequence of a full-length cDNA encoding Ascaris suum malic enzyme.
Academic Article	Pre-steady-state kinetics reveal a slow isomerization of the enzyme-NAD complex in the NAD-malic enzyme reaction.
Academic Article	Expression, purification, and characterization of the recombinant NAD-malic enzyme from Ascaris suum.
Grant	STRUCTURE AND MECHANISM OF NAD-MALIC ENZYME
Grant	KINETIC AND CHEMICAL MECHANISM OF ENZYMES
Grant	KINETIC AND CHEMICAL MECHANISM OF ENZYMES

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Ascaris