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Cook, Paul
One or more keywords matched the following items that are connected to Cook, Paul
Item TypeName
Concept Biochemistry
Academic Article Alpha-secondary tritium kinetic isotope effects indicate hydrogen tunneling and coupled motion occur in the oxidation of L-malate by NAD-malic enzyme.
Academic Article Glutamate 325 is a general acid-base catalyst in the reaction catalyzed by fructose-2,6-bisphosphatase.
Academic Article Kinetic analysis of YPD1-dependent phosphotransfer reactions in the yeast osmoregulatory phosphorelay system.
Academic Article Optimum activity of the phosphofructokinase from Ascaris suum requires more than one metal ion.
Academic Article Acid-base chemical mechanism of homocitrate synthase from Saccharomyces cerevisiae.
Academic Article Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article Role of the S128, H186, and N187 triad in substrate binding and decarboxylation in the sheep liver 6-phosphogluconate dehydrogenase reaction.
Academic Article Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes.
Academic Article Proper positioning of the nicotinamide ring is crucial for the Ascaris suum malic enzyme reaction.
Academic Article Chemical mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Academic Article Potassium is an activator of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Academic Article Isotope exchange at equilibrium indicates a steady state ordered kinetic mechanism for human sulfotransferase.
Academic Article Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article Kinetic mechanism of the adenosine 3',5'-monophosphate dependent protein kinase catalytic subunit in the direction of magnesium adenosine 5'-diphosphate phosphorylation.
Academic Article pH dependence of the absorbance and 31P NMR spectra of O-acetylserine sulfhydrylase in the absence and presence of O-acetyl-L-serine.
Academic Article pH dependence of the kinetic parameters for the pyrophosphate-dependent phosphofructokinase reaction supports a proton-shuttle mechanism.
Academic Article Substrate activation by malate induced by oxalate in the Ascaris suum NAD-malic enzyme reaction.
Academic Article Chemical mechanism of the adenosine cyclic 3',5'-monophosphate dependent protein kinase from pH studies.
Academic Article Isotope exchange as a probe of the kinetic mechanism of pyrophosphate-dependent phosphofructokinase.
Academic Article Kinetic mechanism of pyrophosphate-dependent phosphofructokinase from Propionibacterium freudenreichii.
Academic Article Kinetic studies to determine the mechanism of regulation of bovine liver glutamate dehydrogenase by nucleotide effectors.
Academic Article Acid-base catalytic mechanism and pH dependence of fructose 2,6-bisphosphate activation of the Ascaris suum phosphofructokinase.
Academic Article Isotope partitioning with Ascaris suum phosphofructokinase is consistent with an ordered kinetic mechanism.
Academic Article Kinetic isotope effects as a probe of the beta-elimination reaction catalyzed by O-acetylserine sulfhydrylase.
Academic Article Formation of the alpha-aminoacrylate immediate limits the overall reaction catalyzed by O-acetylserine sulfhydrylase.
Academic Article Tryptophan luminescence as a probe of enzyme conformation along the O-acetylserine sulfhydrylase reaction pathway.
Academic Article Time-resolved fluorescence of O-acetylserine sulfhydrylase catalytic intermediates.
Academic Article Mapping the active site topography of the NAD-malic enzyme via alanine-scanning site-directed mutagenesis.
Academic Article Lysine 183 is the general base in the 6-phosphogluconate dehydrogenase-catalyzed reaction.
Academic Article Characterization of the allosteric anion-binding site of O-acetylserine sulfhydrylase.
Academic Article Crystal structure of the malic enzyme from Ascaris suum complexed with nicotinamide adenine dinucleotide at 2.3 A resolution.
Academic Article Kinetic mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae.
Academic Article Role of methionine-13 in the catalytic mechanism of 6-phosphogluconate dehydrogenase from sheep liver.
Academic Article A catalytic triad is responsible for acid-base chemistry in the Ascaris suum NAD-malic enzyme.
Academic Article Mechanism of the addition half of the O-acetylserine sulfhydrylase-A reaction.
Academic Article Bisubstrate inhibition: Theory and application to N-acetyltransferases.
Academic Article A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article Complete kinetic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Academic Article Overall kinetic mechanism of saccharopine dehydrogenase (L-glutamate forming) from Saccharomyces cerevisiae.
Academic Article Chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae.
Academic Article Site-directed mutagenesis as a probe of the acid-base catalytic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Academic Article Identification of the structural determinants for the stability of substrate and aminoacrylate external Schiff bases in O-acetylserine sulfhydrylase-A.
Academic Article Modification of the ATP inhibitory site of the Ascaris suum phosphofructokinase results in the stabilization of an inactive T state.
Academic Article Carbohydrate substrate specificity of bacterial and plant pyrophosphate-dependent phosphofructokinases.
Academic Article Kinetic studies on the activation of pyrophosphate-dependent phosphofructokinase from mung bean by fructose 2,6-bisphosphate and related compounds.
Academic Article Isotope partitioning in the adenosine 3',5'-monophosphate dependent protein kinase reaction indicates a steady-state random kinetic mechanism.
Academic Article Use of primary deuterium and 15N isotope effects to deduce the relative rates of steps in the mechanisms of alanine and glutamate dehydrogenases.
Academic Article Adenosine cyclic 3',5'-monophosphate dependent protein kinase: kinetic mechanism for the bovine skeletal muscle catalytic subunit.
Academic Article pH studies toward the elucidation of the auxiliary catalyst for pig heart aspartate aminotransferase.
Academic Article Kinetic mechanism and location of rate-determining steps for aspartase from Hafnia alvei.
Academic Article Kinetic mechanism in the direction of oxidative decarboxylation for NAD-malic enzyme from Ascaris suum.
Academic Article Determination of dissociation constants for enzyme-reactant complexes for NAD-malic enzyme by modulation of the thiol inactivation rate.
Academic Article Use of isotope effects and pH studies to determine the chemical mechanism of Bacillus subtilis L-alanine dehydrogenase.
Academic Article Metal ion activator effects on intrinsic isotope effects for hydride transfer from decarboxylation in the reaction catalyzed by the NAD-malic enzyme from Ascaris suum.
Academic Article A change in the internal aldimine lysine (K42) in O-acetylserine sulfhydrylase to alanine indicates its importance in transimination and as a general base catalyst.
Academic Article Secondary tritium and solvent deuterium isotope effects as a probe of the reaction catalyzed by porcine recombinant dihydropyrimidine dehydrogenase.
Academic Article Cysteine 42 is important for maintaining an integral active site for O-acetylserine sulfhydrylase resulting in the stabilization of the alpha-aminoacrylate intermediate.
Academic Article Oxidative decarboxylation of 6-phosphogluconate by 6-phosphogluconate dehydrogenase proceeds by a stepwise mechanism with NADP and APADP as oxidants.
Academic Article Expression and stereochemical and isotope effect studies of active 4-oxalocrotonate decarboxylase.
Academic Article Tartrate dehydrogenase catalyzes the stepwise oxidative decarboxylation of D-malate with both NAD and thio-NAD.
Academic Article Alternative substrates for malic enzyme: oxidative decarboxylation of L-aspartate.
Academic Article Ascaris suum NAD-malic enzyme is activated by L-malate and fumarate binding to separate allosteric sites.
Academic Article Multiple isotope effects with alternative dinucleotide substrates as a probe of the malic enzyme reaction.
Academic Article Modification of a thiol at the active site of the Ascaris suum NAD-malic enzyme results in changes in the rate-determining steps for oxidative decarboxylation of L-malate.
Academic Article Reaction of serine-glyoxylate aminotransferase with the alternative substrate ketomalonate indicates rate-limiting protonation of a quinonoid intermediate.
Academic Article An isothermal titration calorimetry study of the binding of substrates and ligands to the tartrate dehydrogenase from Pseudomonas putida reveals half-of-the-sites reactivity.
Academic Article Isotope partitioning for NAD-malic enzyme from Ascaris suum confirms a steady-state random kinetic mechanism.
Academic Article Control of ionizable residues in the catalytic mechanism of tryptophan synthase from Salmonella typhimurium.
Academic Article Crystal structures of ligand-bound saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article Roles of histidines 154 and 189 and aspartate 139 in the active site of serine acetyltransferase from Haemophilus influenzae.
Academic Article Evidence for a catalytic dyad in the active site of homocitrate synthase from Saccharomyces cerevisiae.
Academic Article Kinetics and mechanism of benzoylformate decarboxylase using 13C and solvent deuterium isotope effects on benzoylformate and benzoylformate analogues.
Academic Article Effects of osmolytes on the SLN1-YPD1-SSK1 phosphorelay system from Saccharomyces cerevisiae.
Academic Article Evidence from nitrogen-15 and solvent deuterium isotope effects on the chemical mechanism of adenosine deaminase.
Academic Article Protonation mechanism and location of rate-determining steps for the Ascaris suum nicotinamide adenine dinucleotide-malic enzyme reaction from isotope effects and pH studies.
Academic Article Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions.
Academic Article Use of pH studies to elucidate the catalytic mechanism of rabbit muscle creatine kinase.
Academic Article Mechanistic deductions from isotope effects in multireactant enzyme mechanisms.
Academic Article pH variation of isotope effects in enzyme-catalyzed reactions. 1. Isotope- and pH-dependent steps the same.
Academic Article pH variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase.
Academic Article Secondary deuterium and nitrogen-15 isotope effects in enzyme-catalyzed reactions. Chemical mechanism of liver alcohol dehydrogenase.
Academic Article Lanthanide pyrophosphates as substrates for the pyrophosphate-dependent phosphofructokinases from Propionibacterium freudenreichii and Phaseolus aureus: evidence for a second metal ion required for reaction.
Academic Article Product binding to the alpha-carboxyl subsite results in a conformational change at the active site of O-acetylserine sulfhydrylase-A: evidence from fluorescence spectroscopy.
Academic Article Stepwise versus concerted oxidative decarboxylation catalyzed by malic enzyme: a reinvestigation.
Academic Article Kinetic mechanism of serine transacetylase from Salmonella typhimurium.
Academic Article pH dependence of the kinetic mechanism of the adenosine 3',5'-monophosphate dependent protein kinase catalytic subunit in the direction of magnesium adenosine 5'-diphosphate phosphorylation.
Academic Article Glutamate 190 is a general acid catalyst in the 6-phosphogluconate-dehydrogenase-catalyzed reaction.
Academic Article Multiple isotope effects as a probe of proton and hydride transfer in the 6-phosphogluconate dehydrogenase reaction.
Academic Article Lysine 199 is the general acid in the NAD-malic enzyme reaction.
Academic Article Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction.
Academic Article Chemical mechanism of the serine acetyltransferase from Haemophilus influenzae.
Academic Article Multiple roles of arginine 181 in binding and catalysis in the NAD-malic enzyme from Ascaris suum.
Academic Article Proper orientation of the nicotinamide ring of NADP is important for the precatalytic conformational change in the 6-phosphogluconate dehydrogenase reaction.
Academic Article A lysine-tyrosine pair carries out acid-base chemistry in the metal ion-dependent pyridine dinucleotide-linked beta-hydroxyacid oxidative decarboxylases.
Academic Article Introduction to the special issue. Foreword.
Academic Article pH dependence of kinetic parameters for oxalacetate decarboxylation and pyruvate reduction reactions catalyzed by malic enzyme.
Academic Article Identification and spectral characterization of the external aldimine of the O-acetylserine sulfhydrylase reaction.
Academic Article Acid-base chemical mechanism of O-acetylserine sulfhydrylases-A and -B from pH studies.
Academic Article Product dependence of deuterium isotope effects in enzyme-catalyzed reactions.
Academic Article Pre-steady-state kinetics reveal a slow isomerization of the enzyme-NAD complex in the NAD-malic enzyme reaction.
Academic Article Overall kinetic mechanism of 6-phosphogluconate dehydrogenase from Candida utilis.
Academic Article Chemical mechanism of 6-phosphogluconate dehydrogenase from Candida utilis from pH studies.
Academic Article Acid-base catalytic mechanism of dihydropyrimidinase from pH studies.
Academic Article Kinetic mechanisms of the A and B isozymes of O-acetylserine sulfhydrylase from Salmonella typhimurium LT-2 using the natural and alternative reactants.
Academic Article Chemical mechanism of the fructose-6-phosphate,2-kinase reaction from the pH dependence of kinetic parameters of site-directed mutants of active site basic residues.
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  • Biochemistry