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Cook, Paul

One or more keywords matched the following items that are connected to Cook, Paul

Item Type	Name
Concept	Deuterium
Concept	Hydrogen
Concept	Hydrogen Bonding
Concept	Hydrogen-Ion Concentration
Concept	Deuterium Exchange Measurement
Academic Article	Time-resolved fluorescence of O-acetylserine sulfhydrylase.
Academic Article	Alpha-secondary tritium kinetic isotope effects indicate hydrogen tunneling and coupled motion occur in the oxidation of L-malate by NAD-malic enzyme.
Academic Article	Glutamate 325 is a general acid-base catalyst in the reaction catalyzed by fructose-2,6-bisphosphatase.
Academic Article	Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes.
Academic Article	Effect of mutation of lysine-120, located at the entry to the active site of O-acetylserine sulfhydrylase-A from Salmonella typhimurium.
Academic Article	Role of Histidine-152 in cofactor orientation in the PLP-dependent O-acetylserine sulfhydrylase reaction.
Academic Article	Chemical mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Potassium is an activator of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Evidence for an induced conformational change in the catalytic mechanism of homoisocitrate dehydrogenase for Saccharomyces cerevisiae: Characterization of the D271N mutant enzyme.
Academic Article	Probing the chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae using site-directed mutagenesis.
Academic Article	Kinetic mechanism of the adenosine 3',5'-monophosphate dependent protein kinase catalytic subunit in the direction of magnesium adenosine 5'-diphosphate phosphorylation.
Academic Article	pH dependence of the absorbance and 31P NMR spectra of O-acetylserine sulfhydrylase in the absence and presence of O-acetyl-L-serine.
Academic Article	pH dependence of the kinetic parameters for the pyrophosphate-dependent phosphofructokinase reaction supports a proton-shuttle mechanism.
Academic Article	Chemical mechanism of the adenosine cyclic 3',5'-monophosphate dependent protein kinase from pH studies.
Academic Article	Inactivation of pyrophosphate-dependent phosphofructokinase from Propionibacterium freudenreichii by pyridoxal 5'-phosphate. Determination of the pH dependence of enzyme-reactant dissociation constants from protection against inactivation.
Academic Article	Kinetic studies to determine the mechanism of regulation of bovine liver glutamate dehydrogenase by nucleotide effectors.
Academic Article	Acid-base chemical mechanism of aspartase from Hafnia alvei.
Academic Article	Acid-base catalytic mechanism and pH dependence of fructose 2,6-bisphosphate activation of the Ascaris suum phosphofructokinase.
Academic Article	Kinetic isotope effects as a probe of the beta-elimination reaction catalyzed by O-acetylserine sulfhydrylase.
Academic Article	Tryptophan luminescence as a probe of enzyme conformation along the O-acetylserine sulfhydrylase reaction pathway.
Academic Article	Ligand binding induces a large conformational change in O-acetylserine sulfhydrylase from Salmonella typhimurium.
Academic Article	Lysine 183 is the general base in the 6-phosphogluconate dehydrogenase-catalyzed reaction.
Academic Article	Initial velocity, spectral, and pH studies of the serine-glyoxylate aminotransferase from Hyphomicrobiuim methylovorum.
Academic Article	Characterization of the allosteric anion-binding site of O-acetylserine sulfhydrylase.
Academic Article	Role of methionine-13 in the catalytic mechanism of 6-phosphogluconate dehydrogenase from sheep liver.
Academic Article	A catalytic triad is responsible for acid-base chemistry in the Ascaris suum NAD-malic enzyme.
Academic Article	Mechanism of the addition half of the O-acetylserine sulfhydrylase-A reaction.
Academic Article	A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae.
Academic Article	Site-directed mutagenesis as a probe of the acid-base catalytic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation.
Academic Article	Mechanism of the aromatic aminotransferase encoded by the Aro8 gene from Saccharomyces cerevisiae.
Academic Article	Correlation between hysteresis and allosteric properties for phosphofructokinase from Ascaris suum.
Academic Article	Reaction of Ascaris suum phosphofructokinase with diethylpyrocarbonate. Inactivation and desensitization to allosteric modulation.
Academic Article	Use of primary deuterium and 15N isotope effects to deduce the relative rates of steps in the mechanisms of alanine and glutamate dehydrogenases.
Academic Article	Solvent isotope effects on the reaction catalyzed by yeast hexokinase.
Academic Article	pH studies toward the elucidation of the auxiliary catalyst for pig heart aspartate aminotransferase.
Academic Article	Determination of dissociation constants for enzyme-reactant complexes for NAD-malic enzyme by modulation of the thiol inactivation rate.
Academic Article	Use of isotope effects and pH studies to determine the chemical mechanism of Bacillus subtilis L-alanine dehydrogenase.
Academic Article	Metal ion activator effects on intrinsic isotope effects for hydride transfer from decarboxylation in the reaction catalyzed by the NAD-malic enzyme from Ascaris suum.
Academic Article	Substitution of pyridoxal 5'-phosphate in the O-acetylserine sulfhydrylase from Salmonella typhimurium by cofactor analogs provides a test of the mechanism proposed for formation of the alpha-aminoacrylate intermediate.
Academic Article	Role of the divalent metal ion in the NAD:malic enzyme reaction: an ESEEM determination of the ground state conformation of malate in the E:Mn:malate complex.
Academic Article	Secondary tritium and solvent deuterium isotope effects as a probe of the reaction catalyzed by porcine recombinant dihydropyrimidine dehydrogenase.
Academic Article	Cysteine 42 is important for maintaining an integral active site for O-acetylserine sulfhydrylase resulting in the stabilization of the alpha-aminoacrylate intermediate.
Academic Article	Oxidative decarboxylation of 6-phosphogluconate by 6-phosphogluconate dehydrogenase proceeds by a stepwise mechanism with NADP and APADP as oxidants.
Academic Article	Expression and stereochemical and isotope effect studies of active 4-oxalocrotonate decarboxylase.
Academic Article	Tartrate dehydrogenase catalyzes the stepwise oxidative decarboxylation of D-malate with both NAD and thio-NAD.
Academic Article	Alternative substrates for malic enzyme: oxidative decarboxylation of L-aspartate.
Academic Article	Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters.
Academic Article	Multiple isotope effects with alternative dinucleotide substrates as a probe of the malic enzyme reaction.
Academic Article	Modification of a thiol at the active site of the Ascaris suum NAD-malic enzyme results in changes in the rate-determining steps for oxidative decarboxylation of L-malate.
Academic Article	Reaction of serine-glyoxylate aminotransferase with the alternative substrate ketomalonate indicates rate-limiting protonation of a quinonoid intermediate.
Academic Article	Control of ionizable residues in the catalytic mechanism of tryptophan synthase from Salmonella typhimurium.
Academic Article	Roles of histidines 154 and 189 and aspartate 139 in the active site of serine acetyltransferase from Haemophilus influenzae.
Academic Article	Evidence for a catalytic dyad in the active site of homocitrate synthase from Saccharomyces cerevisiae.
Academic Article	Molecular basis for the isozymes of bovine glucose-6-phosphate isomerase.
Academic Article	Kinetics and mechanism of benzoylformate decarboxylase using 13C and solvent deuterium isotope effects on benzoylformate and benzoylformate analogues.
Academic Article	A two-step process controls the formation of the bienzyme cysteine synthase complex.
Academic Article	Evidence from nitrogen-15 and solvent deuterium isotope effects on the chemical mechanism of adenosine deaminase.
Academic Article	Protonation mechanism and location of rate-determining steps for the Ascaris suum nicotinamide adenine dinucleotide-malic enzyme reaction from isotope effects and pH studies.
Academic Article	Kinetic and chemical mechanisms of homocitrate synthase from Thermus thermophilus.
Academic Article	Modification of an arginine residue essential for the activity of NAD-malic enzyme from Ascaris suum.
Academic Article	Supporting role of lysine 13 and glutamate 16 in the acid-base mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions.
Academic Article	Use of pH studies to elucidate the catalytic mechanism of rabbit muscle creatine kinase.
Academic Article	pH variation of isotope effects in enzyme-catalyzed reactions. 1. Isotope- and pH-dependent steps the same.
Academic Article	pH variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase.
Academic Article	Secondary deuterium and nitrogen-15 isotope effects in enzyme-catalyzed reactions. Chemical mechanism of liver alcohol dehydrogenase.
Academic Article	Product binding to the alpha-carboxyl subsite results in a conformational change at the active site of O-acetylserine sulfhydrylase-A: evidence from fluorescence spectroscopy.
Academic Article	pH dependence of the kinetic mechanism of the adenosine 3',5'-monophosphate dependent protein kinase catalytic subunit in the direction of magnesium adenosine 5'-diphosphate phosphorylation.
Academic Article	Kinetic and chemical mechanisms of the sheep liver 6-phosphogluconate dehydrogenase.
Academic Article	Catalytic competence of O-acetylserine sulfhydrylase in the crystal probed by polarized absorption microspectrophotometry.
Academic Article	Glutamate 190 is a general acid catalyst in the 6-phosphogluconate-dehydrogenase-catalyzed reaction.
Academic Article	Multiple isotope effects as a probe of proton and hydride transfer in the 6-phosphogluconate dehydrogenase reaction.
Academic Article	Lysine 199 is the general acid in the NAD-malic enzyme reaction.
Academic Article	Identification of an allosteric anion-binding site on O-acetylserine sulfhydrylase: structure of the enzyme with chloride bound.
Academic Article	Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction.
Academic Article	Chemical mechanism of the serine acetyltransferase from Haemophilus influenzae.
Academic Article	The serine acetyltransferase reaction: acetyl transfer from an acylpantothenyl donor to an alcohol.
Academic Article	The 2'-phosphate of NADP is responsible for proper orientation of the nicotinamide ring in the oxidative decarboxylation reaction catalyzed by sheep liver 6-phosphogluconate dehydrogenase.
Academic Article	Multiple roles of arginine 181 in binding and catalysis in the NAD-malic enzyme from Ascaris suum.
Academic Article	The oxidation state of active site thiols determines activity of saccharopine dehydrogenase at low pH.
Academic Article	Stereoselective preparation of deuterated reduced nicotinamide adenine nucleotides and substrates by enzymatic synthesis.
Academic Article	pH dependence of kinetic parameters for oxalacetate decarboxylation and pyruvate reduction reactions catalyzed by malic enzyme.
Academic Article	The pH dependence of the reductive carboxylation of pyruvate by malic enzyme.
Academic Article	Diethylpyrocarbonate inactivation of NAD-malic enzyme from Ascaris suum.
Academic Article	Identification and spectral characterization of the external aldimine of the O-acetylserine sulfhydrylase reaction.
Academic Article	Acid-base chemical mechanism of O-acetylserine sulfhydrylases-A and -B from pH studies.
Academic Article	A pH-dependent allosteric transition in Ascaris suum phosphofructokinase distinct from that observed with fructose 2,6-bisphosphate.
Academic Article	The 2'-phosphate of NADP is critical for optimum productive binding to 6-phosphogluconate dehydrogenase from Candida utilis.
Academic Article	Acid base catalytic mechanism of the dihydropyrimidine dehydrogenase from pH studies.
Academic Article	Product dependence of deuterium isotope effects in enzyme-catalyzed reactions.
Academic Article	Chemical mechanism of 6-phosphogluconate dehydrogenase from Candida utilis from pH studies.
Academic Article	Acid-base catalytic mechanism of dihydropyrimidinase from pH studies.
Academic Article	Chemical mechanism of the fructose-6-phosphate,2-kinase reaction from the pH dependence of kinetic parameters of site-directed mutants of active site basic residues.
Academic Article	Purification, characterization, and kinetics of porcine recombinant dihydropyrimidine dehydrogenase.
Grant	STRUCTURE AND MECHANISM OF NAD-MALIC ENZYME

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Deuterium