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Cook, Paul
One or more keywords matched the following items that are connected to Cook, Paul
Item TypeName
Concept Kinetics
Academic Article Alpha-secondary tritium kinetic isotope effects indicate hydrogen tunneling and coupled motion occur in the oxidation of L-malate by NAD-malic enzyme.
Academic Article Kinetic characterization of a T-state of Ascaris suum phosphofructokinase with heterotropic negative cooperativity by ATP eliminated.
Academic Article Glutamate 325 is a general acid-base catalyst in the reaction catalyzed by fructose-2,6-bisphosphatase.
Academic Article Pyridoxal 5'-phosphate-dependent alpha,beta-elimination reactions: mechanism of O-acetylserine sulfhydrylase.
Academic Article Dihydropyrimidine amidohydrolases and dihydroorotases share the same origin and several enzymatic properties.
Academic Article A three-dimensional homology model of the O-acetylserine sulfhydrylase-B from Salmonella typhimurium.
Academic Article Optimum activity of the phosphofructokinase from Ascaris suum requires more than one metal ion.
Academic Article Acid-base chemical mechanism of homocitrate synthase from Saccharomyces cerevisiae.
Academic Article Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article Role of the S128, H186, and N187 triad in substrate binding and decarboxylation in the sheep liver 6-phosphogluconate dehydrogenase reaction.
Academic Article Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article Effect of mutation of lysine-120, located at the entry to the active site of O-acetylserine sulfhydrylase-A from Salmonella typhimurium.
Academic Article Role of Histidine-152 in cofactor orientation in the PLP-dependent O-acetylserine sulfhydrylase reaction.
Academic Article Chemical mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Academic Article Examination of intrinsic sulfonamide resistance in Bacillus anthracis: a novel assay for dihydropteroate synthase.
Academic Article Isotope exchange at equilibrium indicates a steady state ordered kinetic mechanism for human sulfotransferase.
Academic Article Glutamates 78 and 122 in the active site of saccharopine dehydrogenase contribute to reactant binding and modulate the basicity of the acid-base catalysts.
Academic Article Reaction product affinity regulates activation of human sulfotransferase 1A1 PAP sulfation.
Academic Article Kinetics of activated thrombin-activatable fibrinolysis inhibitor (TAFIa)-catalyzed cleavage of C-terminal lysine residues of fibrin degradation products and removal of plasminogen-binding sites.
Academic Article Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article Kinetic mechanism of the adenosine 3',5'-monophosphate dependent protein kinase catalytic subunit in the direction of magnesium adenosine 5'-diphosphate phosphorylation.
Academic Article Mechanism of activation of the NAD-malic enzyme from Ascaris suum by fumarate.
Academic Article pH dependence of the absorbance and 31P NMR spectra of O-acetylserine sulfhydrylase in the absence and presence of O-acetyl-L-serine.
Academic Article pH dependence of the kinetic parameters for the pyrophosphate-dependent phosphofructokinase reaction supports a proton-shuttle mechanism.
Academic Article Substrate activation by malate induced by oxalate in the Ascaris suum NAD-malic enzyme reaction.
Academic Article Chemical mechanism of the adenosine cyclic 3',5'-monophosphate dependent protein kinase from pH studies.
Academic Article Inactivation of pyrophosphate-dependent phosphofructokinase from Propionibacterium freudenreichii by pyridoxal 5'-phosphate. Determination of the pH dependence of enzyme-reactant dissociation constants from protection against inactivation.
Academic Article Isotope exchange as a probe of the kinetic mechanism of pyrophosphate-dependent phosphofructokinase.
Academic Article Kinetic mechanism of pyrophosphate-dependent phosphofructokinase from Propionibacterium freudenreichii.
Academic Article Kinetic studies to determine the mechanism of regulation of bovine liver glutamate dehydrogenase by nucleotide effectors.
Academic Article Acid-base chemical mechanism of aspartase from Hafnia alvei.
Academic Article Acid-base catalytic mechanism and pH dependence of fructose 2,6-bisphosphate activation of the Ascaris suum phosphofructokinase.
Academic Article Isotope partitioning with Ascaris suum phosphofructokinase is consistent with an ordered kinetic mechanism.
Academic Article Kinetic isotope effects as a probe of the beta-elimination reaction catalyzed by O-acetylserine sulfhydrylase.
Academic Article Formation of the alpha-aminoacrylate immediate limits the overall reaction catalyzed by O-acetylserine sulfhydrylase.
Academic Article Time-resolved fluorescence of O-acetylserine sulfhydrylase catalytic intermediates.
Academic Article Mapping the active site topography of the NAD-malic enzyme via alanine-scanning site-directed mutagenesis.
Academic Article Lysine 183 is the general base in the 6-phosphogluconate dehydrogenase-catalyzed reaction.
Academic Article Initial velocity, spectral, and pH studies of the serine-glyoxylate aminotransferase from Hyphomicrobiuim methylovorum.
Academic Article Characterization of the allosteric anion-binding site of O-acetylserine sulfhydrylase.
Academic Article Alpha,beta-elimination reaction of O-acetylserine sulfhydrylase. Is the pyridine ring required?
Academic Article Kinetic mechanism of the serine acetyltransferase from Haemophilus influenzae.
Academic Article Role of methionine-13 in the catalytic mechanism of 6-phosphogluconate dehydrogenase from sheep liver.
Academic Article A catalytic triad is responsible for acid-base chemistry in the Ascaris suum NAD-malic enzyme.
Academic Article Mechanism of the addition half of the O-acetylserine sulfhydrylase-A reaction.
Academic Article Bisubstrate inhibition: Theory and application to N-acetyltransferases.
Academic Article A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article Complete kinetic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Academic Article Overall kinetic mechanism of saccharopine dehydrogenase (L-glutamate forming) from Saccharomyces cerevisiae.
Academic Article Chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae.
Academic Article (31)P NMR studies of O-acetylserine sulfhydrylase-B from Salmonella typhimurium.
Academic Article Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation.
Academic Article Effector-induced conformational transitions in Ascaris suum phosphofructokinase. A fluorescence and circular dichroism study.
Academic Article Fructose 2,6-bisphosphate and AMP increase the affinity of the Ascaris suum phosphofructokinase for fructose 6-phosphate in a process separate from the relief of ATP inhibition.
Academic Article Correlation between hysteresis and allosteric properties for phosphofructokinase from Ascaris suum.
Academic Article Reaction of Ascaris suum phosphofructokinase with diethylpyrocarbonate. Inactivation and desensitization to allosteric modulation.
Academic Article Kinetic mechanism of Ascaris suum phosphofructokinase desensitized to allosteric modulation by diethylpyrocarbonate modification.
Academic Article Carbohydrate substrate specificity of bacterial and plant pyrophosphate-dependent phosphofructokinases.
Academic Article Kinetic studies on the activation of pyrophosphate-dependent phosphofructokinase from mung bean by fructose 2,6-bisphosphate and related compounds.
Academic Article Isotope partitioning in the adenosine 3',5'-monophosphate dependent protein kinase reaction indicates a steady-state random kinetic mechanism.
Academic Article The kinetic mechanism of human placental aldose reductase and aldehyde reductase II.
Academic Article Use of primary deuterium and 15N isotope effects to deduce the relative rates of steps in the mechanisms of alanine and glutamate dehydrogenases.
Academic Article Adenosine cyclic 3',5'-monophosphate dependent protein kinase: kinetic mechanism for the bovine skeletal muscle catalytic subunit.
Academic Article Solvent isotope effects on the reaction catalyzed by yeast hexokinase.
Academic Article pH studies toward the elucidation of the auxiliary catalyst for pig heart aspartate aminotransferase.
Academic Article Kinetic mechanism and location of rate-determining steps for aspartase from Hafnia alvei.
Academic Article Kinetic mechanism in the direction of oxidative decarboxylation for NAD-malic enzyme from Ascaris suum.
Academic Article Determination of dissociation constants for enzyme-reactant complexes for NAD-malic enzyme by modulation of the thiol inactivation rate.
Academic Article Metal ion activator effects on intrinsic isotope effects for hydride transfer from decarboxylation in the reaction catalyzed by the NAD-malic enzyme from Ascaris suum.
Academic Article Purification and characterization of dihydropyrimidine dehydrogenase from Alcaligenes eutrophus.
Academic Article Substitution of pyridoxal 5'-phosphate in the O-acetylserine sulfhydrylase from Salmonella typhimurium by cofactor analogs provides a test of the mechanism proposed for formation of the alpha-aminoacrylate intermediate.
Academic Article A change in the internal aldimine lysine (K42) in O-acetylserine sulfhydrylase to alanine indicates its importance in transimination and as a general base catalyst.
Academic Article Cysteine 42 is important for maintaining an integral active site for O-acetylserine sulfhydrylase resulting in the stabilization of the alpha-aminoacrylate intermediate.
Academic Article Oxidative decarboxylation of 6-phosphogluconate by 6-phosphogluconate dehydrogenase proceeds by a stepwise mechanism with NADP and APADP as oxidants.
Academic Article Expression and stereochemical and isotope effect studies of active 4-oxalocrotonate decarboxylase.
Academic Article Tartrate dehydrogenase catalyzes the stepwise oxidative decarboxylation of D-malate with both NAD and thio-NAD.
Academic Article Alternative substrates for malic enzyme: oxidative decarboxylation of L-aspartate.
Academic Article Ascaris suum NAD-malic enzyme is activated by L-malate and fumarate binding to separate allosteric sites.
Academic Article Stabilization and characterization of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae.
Academic Article Structure and mechanism of O-acetylserine sulfhydrylase.
Academic Article Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters.
Academic Article Multiple isotope effects with alternative dinucleotide substrates as a probe of the malic enzyme reaction.
Academic Article Modification of a thiol at the active site of the Ascaris suum NAD-malic enzyme results in changes in the rate-determining steps for oxidative decarboxylation of L-malate.
Academic Article Regulatory mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae. II. Theory.
Academic Article Regulatory mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae. I. Kinetic studies.
Academic Article Reaction of serine-glyoxylate aminotransferase with the alternative substrate ketomalonate indicates rate-limiting protonation of a quinonoid intermediate.
Academic Article An isothermal titration calorimetry study of the binding of substrates and ligands to the tartrate dehydrogenase from Pseudomonas putida reveals half-of-the-sites reactivity.
Academic Article Isotope partitioning for NAD-malic enzyme from Ascaris suum confirms a steady-state random kinetic mechanism.
Academic Article Roles of histidines 154 and 189 and aspartate 139 in the active site of serine acetyltransferase from Haemophilus influenzae.
Academic Article Evidence for a catalytic dyad in the active site of homocitrate synthase from Saccharomyces cerevisiae.
Academic Article Molecular basis for the isozymes of bovine glucose-6-phosphate isomerase.
Academic Article Kinetics and mechanism of benzoylformate decarboxylase using 13C and solvent deuterium isotope effects on benzoylformate and benzoylformate analogues.
Academic Article A two-step process controls the formation of the bienzyme cysteine synthase complex.
Academic Article Evidence from nitrogen-15 and solvent deuterium isotope effects on the chemical mechanism of adenosine deaminase.
Academic Article Protonation mechanism and location of rate-determining steps for the Ascaris suum nicotinamide adenine dinucleotide-malic enzyme reaction from isotope effects and pH studies.
Academic Article Kinetic and chemical mechanisms of homocitrate synthase from Thermus thermophilus.
Academic Article Modification of an arginine residue essential for the activity of NAD-malic enzyme from Ascaris suum.
Academic Article Supporting role of lysine 13 and glutamate 16 in the acid-base mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article Use of pH studies to elucidate the catalytic mechanism of rabbit muscle creatine kinase.
Academic Article Mechanistic deductions from isotope effects in multireactant enzyme mechanisms.
Academic Article pH variation of isotope effects in enzyme-catalyzed reactions. 1. Isotope- and pH-dependent steps the same.
Academic Article pH variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase.
Academic Article Secondary deuterium and nitrogen-15 isotope effects in enzyme-catalyzed reactions. Chemical mechanism of liver alcohol dehydrogenase.
Academic Article Kinetic mechanism of serine transacetylase from Salmonella typhimurium.
Academic Article pH dependence of the kinetic mechanism of the adenosine 3',5'-monophosphate dependent protein kinase catalytic subunit in the direction of magnesium adenosine 5'-diphosphate phosphorylation.
Academic Article Kinetic and chemical mechanisms of the sheep liver 6-phosphogluconate dehydrogenase.
Academic Article Glutamate 190 is a general acid catalyst in the 6-phosphogluconate-dehydrogenase-catalyzed reaction.
Academic Article Multiple isotope effects as a probe of proton and hydride transfer in the 6-phosphogluconate dehydrogenase reaction.
Academic Article Mechanism from isotope effects.
Academic Article Reaction mechanism of fructose-2,6-bisphosphatase. A mutation of nucleophilic catalyst, histidine 256, induces an alteration in the reaction pathway.
Academic Article Lysine 199 is the general acid in the NAD-malic enzyme reaction.
Academic Article Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction.
Academic Article Chemical mechanism of the serine acetyltransferase from Haemophilus influenzae.
Academic Article The serine acetyltransferase reaction: acetyl transfer from an acylpantothenyl donor to an alcohol.
Academic Article Multiple roles of arginine 181 in binding and catalysis in the NAD-malic enzyme from Ascaris suum.
Academic Article A novel, species-specific class of uncompetitive inhibitors of gamma-glutamyl transpeptidase.
Academic Article para-Nitrophenyl sulfate activation of human sulfotransferase 1A1 is consistent with intercepting the E[middle dot]PAP complex and reformation of E[middle dot]PAPS.
Academic Article Exploring O-acetylserine sulfhydrylase-B isoenzyme from Salmonella typhimurium by fluorescence spectroscopy.
Academic Article Kinetic studies of the yeast His-Asp phosphorelay signaling pathway.
Academic Article Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes.
Academic Article The oxidation state of active site thiols determines activity of saccharopine dehydrogenase at low pH.
Academic Article salmonella typhimurium/enzymol.
Academic Article Cysteine synthetase from Salmonella typhimurium LT-2. Aggregation, kinetic behavior, and effect of modifiers.
Academic Article A reaction mechanism from steady state kinetic studies for O-acetylserine sulfhydrylase from Salmonella typhimurium LT-2.
Academic Article Overall mechanism and rate equation for O-acetylserine sulfhydrylase.
Academic Article Kinetic mechanism of dihydropyrimidine dehydrogenase from pig liver.
Academic Article pH dependence of kinetic parameters for oxalacetate decarboxylation and pyruvate reduction reactions catalyzed by malic enzyme.
Academic Article The pH dependence of the reductive carboxylation of pyruvate by malic enzyme.
Academic Article Diethylpyrocarbonate inactivation of NAD-malic enzyme from Ascaris suum.
Academic Article Equilibrium model in an in vitro poly(ADP-ribose) turnover system.
Academic Article Acid-base chemical mechanism of O-acetylserine sulfhydrylases-A and -B from pH studies.
Academic Article The 2'-phosphate of NADP is critical for optimum productive binding to 6-phosphogluconate dehydrogenase from Candida utilis.
Academic Article Acid base catalytic mechanism of the dihydropyrimidine dehydrogenase from pH studies.
Academic Article Product dependence of deuterium isotope effects in enzyme-catalyzed reactions.
Academic Article Pre-steady-state kinetics reveal a slow isomerization of the enzyme-NAD complex in the NAD-malic enzyme reaction.
Academic Article Overall kinetic mechanism of 6-phosphogluconate dehydrogenase from Candida utilis.
Academic Article Chemical mechanism of 6-phosphogluconate dehydrogenase from Candida utilis from pH studies.
Academic Article Acid-base catalytic mechanism of dihydropyrimidinase from pH studies.
Academic Article Kinetic mechanisms of the A and B isozymes of O-acetylserine sulfhydrylase from Salmonella typhimurium LT-2 using the natural and alternative reactants.
Academic Article Expression, purification, and characterization of the recombinant NAD-malic enzyme from Ascaris suum.
Academic Article Chemical mechanism of the fructose-6-phosphate,2-kinase reaction from the pH dependence of kinetic parameters of site-directed mutants of active site basic residues.
Academic Article Purification, characterization, and kinetics of porcine recombinant dihydropyrimidine dehydrogenase.
Grant STRUCTURE/MECHANISM OF 6-PHOSPHOGLUCONATE DEHYDROGENASE
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  • Kinetics