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One or more keywords matched the following items that are connected to Cook, Paul
Item TypeName
Concept Mutagenesis, Site-Directed
Academic Article Kinetic analysis of YPD1-dependent phosphotransfer reactions in the yeast osmoregulatory phosphorelay system.
Academic Article Role of the S128, H186, and N187 triad in substrate binding and decarboxylation in the sheep liver 6-phosphogluconate dehydrogenase reaction.
Academic Article Proper positioning of the nicotinamide ring is crucial for the Ascaris suum malic enzyme reaction.
Academic Article Effect of mutation of lysine-120, located at the entry to the active site of O-acetylserine sulfhydrylase-A from Salmonella typhimurium.
Academic Article Glutamates 78 and 122 in the active site of saccharopine dehydrogenase contribute to reactant binding and modulate the basicity of the acid-base catalysts.
Academic Article The multifaceted pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase.
Academic Article Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article Probing the chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae using site-directed mutagenesis.
Academic Article Mapping the active site topography of the NAD-malic enzyme via alanine-scanning site-directed mutagenesis.
Academic Article Lysine 183 is the general base in the 6-phosphogluconate dehydrogenase-catalyzed reaction.
Academic Article Alpha,beta-elimination reaction of O-acetylserine sulfhydrylase. Is the pyridine ring required?
Academic Article Role of methionine-13 in the catalytic mechanism of 6-phosphogluconate dehydrogenase from sheep liver.
Academic Article Site-directed mutagenesis as a probe of the acid-base catalytic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Academic Article A change in the internal aldimine lysine (K42) in O-acetylserine sulfhydrylase to alanine indicates its importance in transimination and as a general base catalyst.
Academic Article Cloning, expression, purification, and characterization of the 6-phosphogluconate dehydrogenase from sheep liver.
Academic Article Expression and stereochemical and isotope effect studies of active 4-oxalocrotonate decarboxylase.
Academic Article Supporting role of lysine 13 and glutamate 16 in the acid-base mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article Kinetic and chemical mechanisms of the sheep liver 6-phosphogluconate dehydrogenase.
Academic Article Glutamate 190 is a general acid catalyst in the 6-phosphogluconate-dehydrogenase-catalyzed reaction.
Academic Article Reaction mechanism of fructose-2,6-bisphosphatase. A mutation of nucleophilic catalyst, histidine 256, induces an alteration in the reaction pathway.
Academic Article Lysine 199 is the general acid in the NAD-malic enzyme reaction.
Academic Article Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction.
Academic Article Exploring O-acetylserine sulfhydrylase-B isoenzyme from Salmonella typhimurium by fluorescence spectroscopy.
Academic Article The oxidation state of active site thiols determines activity of saccharopine dehydrogenase at low pH.
Academic Article Chemical mechanism of the fructose-6-phosphate,2-kinase reaction from the pH dependence of kinetic parameters of site-directed mutants of active site basic residues.
Grant Lysine Biosynthesis in Yeast
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  • Mutagenesis Site Directed