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Cook, Paul

One or more keywords matched the following items that are connected to Cook, Paul

Item Type	Name
Concept	Acetyl Coenzyme A
Concept	Acyl Coenzyme A
Concept	Coenzyme A
Concept	NAD
Academic Article	Alpha-secondary tritium kinetic isotope effects indicate hydrogen tunneling and coupled motion occur in the oxidation of L-malate by NAD-malic enzyme.
Academic Article	Acid-base chemical mechanism of homocitrate synthase from Saccharomyces cerevisiae.
Academic Article	Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Examination of intrinsic sulfonamide resistance in Bacillus anthracis: a novel assay for dihydropteroate synthase.
Academic Article	Glutamates 78 and 122 in the active site of saccharopine dehydrogenase contribute to reactant binding and modulate the basicity of the acid-base catalysts.
Academic Article	Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Mechanism of activation of the NAD-malic enzyme from Ascaris suum by fumarate.
Academic Article	Substrate activation by malate induced by oxalate in the Ascaris suum NAD-malic enzyme reaction.
Academic Article	Mapping the active site topography of the NAD-malic enzyme via alanine-scanning site-directed mutagenesis.
Academic Article	Crystal structure of the malic enzyme from Ascaris suum complexed with nicotinamide adenine dinucleotide at 2.3 A resolution.
Academic Article	Kinetic mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae.
Academic Article	A catalytic triad is responsible for acid-base chemistry in the Ascaris suum NAD-malic enzyme.
Academic Article	Bisubstrate inhibition: Theory and application to N-acetyltransferases.
Academic Article	Crystallization of the NAD-dependent malic enzyme from the parasitic nematode Ascaris suum.
Academic Article	Use of primary deuterium and 15N isotope effects to deduce the relative rates of steps in the mechanisms of alanine and glutamate dehydrogenases.
Academic Article	Kinetic mechanism in the direction of oxidative decarboxylation for NAD-malic enzyme from Ascaris suum.
Academic Article	Determination of dissociation constants for enzyme-reactant complexes for NAD-malic enzyme by modulation of the thiol inactivation rate.
Academic Article	Use of isotope effects and pH studies to determine the chemical mechanism of Bacillus subtilis L-alanine dehydrogenase.
Academic Article	Metal ion activator effects on intrinsic isotope effects for hydride transfer from decarboxylation in the reaction catalyzed by the NAD-malic enzyme from Ascaris suum.
Academic Article	Role of the divalent metal ion in the NAD:malic enzyme reaction: an ESEEM determination of the ground state conformation of malate in the E:Mn:malate complex.
Academic Article	Tartrate dehydrogenase catalyzes the stepwise oxidative decarboxylation of D-malate with both NAD and thio-NAD.
Academic Article	Kinetic mechanism of NAD:malic enzyme from Ascaris suum in the direction of reductive carboxylation.
Academic Article	Crystallographic studies on Ascaris suum NAD-malic enzyme bound to reduced cofactor and identification of an effector site.
Academic Article	Ascaris suum NAD-malic enzyme is activated by L-malate and fumarate binding to separate allosteric sites.
Academic Article	Stabilization and characterization of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae.
Academic Article	Multiple isotope effects with alternative dinucleotide substrates as a probe of the malic enzyme reaction.
Academic Article	Modification of a thiol at the active site of the Ascaris suum NAD-malic enzyme results in changes in the rate-determining steps for oxidative decarboxylation of L-malate.
Academic Article	Regulatory mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae. I. Kinetic studies.
Academic Article	An isothermal titration calorimetry study of the binding of substrates and ligands to the tartrate dehydrogenase from Pseudomonas putida reveals half-of-the-sites reactivity.
Academic Article	Isotope partitioning for NAD-malic enzyme from Ascaris suum confirms a steady-state random kinetic mechanism.
Academic Article	Protonation mechanism and location of rate-determining steps for the Ascaris suum nicotinamide adenine dinucleotide-malic enzyme reaction from isotope effects and pH studies.
Academic Article	Kinetic and chemical mechanisms of homocitrate synthase from Thermus thermophilus.
Academic Article	Modification of an arginine residue essential for the activity of NAD-malic enzyme from Ascaris suum.
Academic Article	Stepwise versus concerted oxidative decarboxylation catalyzed by malic enzyme: a reinvestigation.
Academic Article	Kinetic mechanism of serine transacetylase from Salmonella typhimurium.
Academic Article	Lysine 199 is the general acid in the NAD-malic enzyme reaction.
Academic Article	The serine acetyltransferase reaction: acetyl transfer from an acylpantothenyl donor to an alcohol.
Academic Article	The 2'-phosphate of NADP is responsible for proper orientation of the nicotinamide ring in the oxidative decarboxylation reaction catalyzed by sheep liver 6-phosphogluconate dehydrogenase.
Academic Article	Multiple roles of arginine 181 in binding and catalysis in the NAD-malic enzyme from Ascaris suum.
Academic Article	Role of residues in the adenosine binding site of NAD of the Ascaris suum malic enzyme.
Academic Article	The oxidation state of active site thiols determines activity of saccharopine dehydrogenase at low pH.
Academic Article	Contribution of K99 and D319 to substrate binding and catalysis in the saccharopine dehydrogenase reaction.
Academic Article	salmonella typhimurium/enzymol.
Academic Article	Cysteine synthetase from Salmonella typhimurium LT-2. Aggregation, kinetic behavior, and effect of modifiers.
Academic Article	Kinetic mechanism of dihydropyrimidine dehydrogenase from pig liver.
Academic Article	Diethylpyrocarbonate inactivation of NAD-malic enzyme from Ascaris suum.
Academic Article	Equilibrium model in an in vitro poly(ADP-ribose) turnover system.
Academic Article	Product dependence of deuterium isotope effects in enzyme-catalyzed reactions.
Academic Article	Pre-steady-state kinetics reveal a slow isomerization of the enzyme-NAD complex in the NAD-malic enzyme reaction.
Academic Article	Expression, purification, and characterization of the recombinant NAD-malic enzyme from Ascaris suum.
Grant	STRUCTURE AND MECHANISM OF NAD-MALIC ENZYME
Grant	KINETIC AND CHEMICAL MECHANISM OF ENZYMES
Grant	KINETIC AND CHEMICAL MECHANISM OF ENZYMES

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