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Cook, Paul

One or more keywords matched the following items that are connected to Cook, Paul

Item Type	Name
Concept	Alcohol Dehydrogenase
Concept	Alcohol Oxidoreductases
Concept	Aldehyde Oxidoreductases
Concept	Aldehyde Reductase
Concept	Carbohydrate Dehydrogenases
Concept	Amino Acid Oxidoreductases
Concept	Glucosephosphate Dehydrogenase
Concept	Glutamate Dehydrogenase
Concept	Glycerolphosphate Dehydrogenase
Concept	L-Lactate Dehydrogenase
Concept	Malate Dehydrogenase
Concept	Isocitrate Dehydrogenase
Concept	Phosphogluconate Dehydrogenase
Concept	Saccharopine Dehydrogenases
Concept	Sugar Alcohol Dehydrogenases
Concept	Dihydrouracil Dehydrogenase (NADP)
Concept	Alanine Dehydrogenase
Concept	Formate Dehydrogenases
Concept	Oxidoreductases
Academic Article	Alpha-secondary tritium kinetic isotope effects indicate hydrogen tunneling and coupled motion occur in the oxidation of L-malate by NAD-malic enzyme.
Academic Article	Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Role of the S128, H186, and N187 triad in substrate binding and decarboxylation in the sheep liver 6-phosphogluconate dehydrogenase reaction.
Academic Article	Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Proper positioning of the nicotinamide ring is crucial for the Ascaris suum malic enzyme reaction.
Academic Article	Chemical mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Examination of intrinsic sulfonamide resistance in Bacillus anthracis: a novel assay for dihydropteroate synthase.
Academic Article	Potassium is an activator of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Glutamates 78 and 122 in the active site of saccharopine dehydrogenase contribute to reactant binding and modulate the basicity of the acid-base catalysts.
Academic Article	Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Evidence for an induced conformational change in the catalytic mechanism of homoisocitrate dehydrogenase for Saccharomyces cerevisiae: Characterization of the D271N mutant enzyme.
Academic Article	Probing the chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae using site-directed mutagenesis.
Academic Article	Mechanism of activation of the NAD-malic enzyme from Ascaris suum by fumarate.
Academic Article	Substrate activation by malate induced by oxalate in the Ascaris suum NAD-malic enzyme reaction.
Academic Article	Kinetic studies to determine the mechanism of regulation of bovine liver glutamate dehydrogenase by nucleotide effectors.
Academic Article	Mapping the active site topography of the NAD-malic enzyme via alanine-scanning site-directed mutagenesis.
Academic Article	Lysine 183 is the general base in the 6-phosphogluconate dehydrogenase-catalyzed reaction.
Academic Article	Crystal structure of the malic enzyme from Ascaris suum complexed with nicotinamide adenine dinucleotide at 2.3 A resolution.
Academic Article	Role of methionine-13 in the catalytic mechanism of 6-phosphogluconate dehydrogenase from sheep liver.
Academic Article	A catalytic triad is responsible for acid-base chemistry in the Ascaris suum NAD-malic enzyme.
Academic Article	A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Complete kinetic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Overall kinetic mechanism of saccharopine dehydrogenase (L-glutamate forming) from Saccharomyces cerevisiae.
Academic Article	Chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae.
Academic Article	Site-directed mutagenesis as a probe of the acid-base catalytic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Crystallization of the NAD-dependent malic enzyme from the parasitic nematode Ascaris suum.
Academic Article	The kinetic mechanism of human placental aldose reductase and aldehyde reductase II.
Academic Article	Use of primary deuterium and 15N isotope effects to deduce the relative rates of steps in the mechanisms of alanine and glutamate dehydrogenases.
Academic Article	Kinetic mechanism in the direction of oxidative decarboxylation for NAD-malic enzyme from Ascaris suum.
Academic Article	Determination of dissociation constants for enzyme-reactant complexes for NAD-malic enzyme by modulation of the thiol inactivation rate.
Academic Article	Use of isotope effects and pH studies to determine the chemical mechanism of Bacillus subtilis L-alanine dehydrogenase.
Academic Article	Metal ion activator effects on intrinsic isotope effects for hydride transfer from decarboxylation in the reaction catalyzed by the NAD-malic enzyme from Ascaris suum.
Academic Article	Purification and characterization of dihydropyrimidine dehydrogenase from Alcaligenes eutrophus.
Academic Article	Role of the divalent metal ion in the NAD:malic enzyme reaction: an ESEEM determination of the ground state conformation of malate in the E:Mn:malate complex.
Academic Article	Secondary tritium and solvent deuterium isotope effects as a probe of the reaction catalyzed by porcine recombinant dihydropyrimidine dehydrogenase.
Academic Article	Cloning, expression, purification, and characterization of the 6-phosphogluconate dehydrogenase from sheep liver.
Academic Article	Oxidative decarboxylation of 6-phosphogluconate by 6-phosphogluconate dehydrogenase proceeds by a stepwise mechanism with NADP and APADP as oxidants.
Academic Article	Tartrate dehydrogenase catalyzes the stepwise oxidative decarboxylation of D-malate with both NAD and thio-NAD.
Academic Article	Alternative substrates for malic enzyme: oxidative decarboxylation of L-aspartate.
Academic Article	Kinetic mechanism of NAD:malic enzyme from Ascaris suum in the direction of reductive carboxylation.
Academic Article	Crystallographic studies on Ascaris suum NAD-malic enzyme bound to reduced cofactor and identification of an effector site.
Academic Article	Ascaris suum NAD-malic enzyme is activated by L-malate and fumarate binding to separate allosteric sites.
Academic Article	Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters.
Academic Article	Multiple isotope effects with alternative dinucleotide substrates as a probe of the malic enzyme reaction.
Academic Article	Modification of a thiol at the active site of the Ascaris suum NAD-malic enzyme results in changes in the rate-determining steps for oxidative decarboxylation of L-malate.
Academic Article	Importance in catalysis of the 6-phosphate-binding site of 6-phosphogluconate in sheep liver 6-phosphogluconate dehydrogenase.
Academic Article	An isothermal titration calorimetry study of the binding of substrates and ligands to the tartrate dehydrogenase from Pseudomonas putida reveals half-of-the-sites reactivity.
Academic Article	Isotope partitioning for NAD-malic enzyme from Ascaris suum confirms a steady-state random kinetic mechanism.
Academic Article	Crystal structures of ligand-bound saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Protonation mechanism and location of rate-determining steps for the Ascaris suum nicotinamide adenine dinucleotide-malic enzyme reaction from isotope effects and pH studies.
Academic Article	Modification of an arginine residue essential for the activity of NAD-malic enzyme from Ascaris suum.
Academic Article	Supporting role of lysine 13 and glutamate 16 in the acid-base mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article	Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions.
Academic Article	Mechanistic deductions from isotope effects in multireactant enzyme mechanisms.
Academic Article	pH variation of isotope effects in enzyme-catalyzed reactions. 1. Isotope- and pH-dependent steps the same.
Academic Article	pH variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase.
Academic Article	Secondary deuterium and nitrogen-15 isotope effects in enzyme-catalyzed reactions. Chemical mechanism of liver alcohol dehydrogenase.
Academic Article	Stepwise versus concerted oxidative decarboxylation catalyzed by malic enzyme: a reinvestigation.
Academic Article	Kinetic and chemical mechanisms of the sheep liver 6-phosphogluconate dehydrogenase.
Academic Article	Glutamate 190 is a general acid catalyst in the 6-phosphogluconate-dehydrogenase-catalyzed reaction.
Academic Article	Multiple isotope effects as a probe of proton and hydride transfer in the 6-phosphogluconate dehydrogenase reaction.
Academic Article	Mechanism from isotope effects.
Academic Article	Lysine 199 is the general acid in the NAD-malic enzyme reaction.
Academic Article	Crystal structure of the his-tagged saccharopine reductase from Saccharomyces cerevisiae at 1.7-A resolution.
Academic Article	The alpha-aminoadipate pathway for lysine biosynthesis in fungi.
Academic Article	The 2'-phosphate of NADP is responsible for proper orientation of the nicotinamide ring in the oxidative decarboxylation reaction catalyzed by sheep liver 6-phosphogluconate dehydrogenase.
Academic Article	Multiple roles of arginine 181 in binding and catalysis in the NAD-malic enzyme from Ascaris suum.
Academic Article	Proper orientation of the nicotinamide ring of NADP is important for the precatalytic conformational change in the 6-phosphogluconate dehydrogenase reaction.
Academic Article	Role of residues in the adenosine binding site of NAD of the Ascaris suum malic enzyme.
Academic Article	The oxidation state of active site thiols determines activity of saccharopine dehydrogenase at low pH.
Academic Article	Contribution of K99 and D319 to substrate binding and catalysis in the saccharopine dehydrogenase reaction.
Academic Article	Stereoselective preparation of deuterated reduced nicotinamide adenine nucleotides and substrates by enzymatic synthesis.
Academic Article	Kinetic mechanism of dihydropyrimidine dehydrogenase from pig liver.
Academic Article	pH dependence of kinetic parameters for oxalacetate decarboxylation and pyruvate reduction reactions catalyzed by malic enzyme.
Academic Article	Diethylpyrocarbonate inactivation of NAD-malic enzyme from Ascaris suum.
Academic Article	The 2'-phosphate of NADP is critical for optimum productive binding to 6-phosphogluconate dehydrogenase from Candida utilis.
Academic Article	Cloning and nucleotide sequence of a full-length cDNA encoding Ascaris suum malic enzyme.
Academic Article	Acid base catalytic mechanism of the dihydropyrimidine dehydrogenase from pH studies.
Academic Article	Product dependence of deuterium isotope effects in enzyme-catalyzed reactions.
Academic Article	Pre-steady-state kinetics reveal a slow isomerization of the enzyme-NAD complex in the NAD-malic enzyme reaction.
Academic Article	Overall kinetic mechanism of 6-phosphogluconate dehydrogenase from Candida utilis.
Academic Article	Chemical mechanism of 6-phosphogluconate dehydrogenase from Candida utilis from pH studies.
Academic Article	Expression, purification, and characterization of the recombinant NAD-malic enzyme from Ascaris suum.
Academic Article	Purification, characterization, and kinetics of porcine recombinant dihydropyrimidine dehydrogenase.
Grant	STRUCTURE AND MECHANISM OF NAD-MALIC ENZYME
Grant	Lysine Biosynthesis in Yeast
Grant	STRUCTURE/MECHANISM OF 6-PHOSPHOGLUCONATE DEHYDROGENASE

Search Criteria

Oxidoreductases