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One or more keywords matched the following items that are connected to Cook, Paul
Item TypeName
Concept Glucose-6-Phosphate Isomerase
Concept Glutathione Transferase
Concept Phosphates
Concept Phosphatidylinositols
Concept Pyridoxal Phosphate
Concept Amino Acid Substitution
Concept Triose-Phosphate Isomerase
Academic Article Time-resolved fluorescence of O-acetylserine sulfhydrylase.
Academic Article Pyridoxal 5'-phosphate-dependent alpha,beta-elimination reactions: mechanism of O-acetylserine sulfhydrylase.
Academic Article Expression of transglutaminase substrate activity on Candida albicans germ tubes through a coiled, disulfide-bonded N-terminal domain of Hwp1 requires C-terminal glycosylphosphatidylinositol modification.
Academic Article Kinetic analysis of YPD1-dependent phosphotransfer reactions in the yeast osmoregulatory phosphorelay system.
Academic Article Role of the S128, H186, and N187 triad in substrate binding and decarboxylation in the sheep liver 6-phosphogluconate dehydrogenase reaction.
Academic Article Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes.
Academic Article Role of Histidine-152 in cofactor orientation in the PLP-dependent O-acetylserine sulfhydrylase reaction.
Academic Article Examination of intrinsic sulfonamide resistance in Bacillus anthracis: a novel assay for dihydropteroate synthase.
Academic Article Glutamates 78 and 122 in the active site of saccharopine dehydrogenase contribute to reactant binding and modulate the basicity of the acid-base catalysts.
Academic Article The multifaceted pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase.
Academic Article Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article Probing the chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae using site-directed mutagenesis.
Academic Article pH dependence of the absorbance and 31P NMR spectra of O-acetylserine sulfhydrylase in the absence and presence of O-acetyl-L-serine.
Academic Article Inactivation of pyrophosphate-dependent phosphofructokinase from Propionibacterium freudenreichii by pyridoxal 5'-phosphate. Determination of the pH dependence of enzyme-reactant dissociation constants from protection against inactivation.
Academic Article Lysine 183 is the general base in the 6-phosphogluconate dehydrogenase-catalyzed reaction.
Academic Article Substitution of pyridoxal 5'-phosphate in D-serine dehydratase from Escherichia coli by cofactor analogues provides information on cofactor binding and catalysis.
Academic Article (31)P NMR studies of O-acetylserine sulfhydrylase-B from Salmonella typhimurium.
Academic Article Identification of the structural determinants for the stability of substrate and aminoacrylate external Schiff bases in O-acetylserine sulfhydrylase-A.
Academic Article Fructose 2,6-bisphosphate and AMP increase the affinity of the Ascaris suum phosphofructokinase for fructose 6-phosphate in a process separate from the relief of ATP inhibition.
Academic Article pH studies toward the elucidation of the auxiliary catalyst for pig heart aspartate aminotransferase.
Academic Article Substitution of pyridoxal 5'-phosphate in the O-acetylserine sulfhydrylase from Salmonella typhimurium by cofactor analogs provides a test of the mechanism proposed for formation of the alpha-aminoacrylate intermediate.
Academic Article A change in the internal aldimine lysine (K42) in O-acetylserine sulfhydrylase to alanine indicates its importance in transimination and as a general base catalyst.
Academic Article O-acetylserine sulfhydrylase.
Academic Article Ascaris suum NAD-malic enzyme is activated by L-malate and fumarate binding to separate allosteric sites.
Academic Article Importance in catalysis of the 6-phosphate-binding site of 6-phosphogluconate in sheep liver 6-phosphogluconate dehydrogenase.
Academic Article Roles of histidines 154 and 189 and aspartate 139 in the active site of serine acetyltransferase from Haemophilus influenzae.
Academic Article Molecular basis for the isozymes of bovine glucose-6-phosphate isomerase.
Academic Article Effects of osmolytes on the SLN1-YPD1-SSK1 phosphorelay system from Saccharomyces cerevisiae.
Academic Article Lanthanide pyrophosphates as substrates for the pyrophosphate-dependent phosphofructokinases from Propionibacterium freudenreichii and Phaseolus aureus: evidence for a second metal ion required for reaction.
Academic Article Product binding to the alpha-carboxyl subsite results in a conformational change at the active site of O-acetylserine sulfhydrylase-A: evidence from fluorescence spectroscopy.
Academic Article Three-dimensional structure of O-acetylserine sulfhydrylase from Salmonella typhimurium.
Academic Article Crystal structure of the H256A mutant of rat testis fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatase. Fructose 6-phosphate in the active site leads to mechanisms for both mutant and wild type bisphosphatase activities.
Academic Article Lysine 199 is the general acid in the NAD-malic enzyme reaction.
Academic Article Identification of an allosteric anion-binding site on O-acetylserine sulfhydrylase: structure of the enzyme with chloride bound.
Academic Article Detection of intermediates in reactions catalyzed by PLP-dependent enzymes: O-acetylserine sulfhydrylase and serine-glyoxalate aminotransferase.
Academic Article Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction.
Academic Article Interaction of serine acetyltransferase with O-acetylserine sulfhydrylase active site: evidence from fluorescence spectroscopy.
Academic Article The 2'-phosphate of NADP is responsible for proper orientation of the nicotinamide ring in the oxidative decarboxylation reaction catalyzed by sheep liver 6-phosphogluconate dehydrogenase.
Academic Article Role of residues in the adenosine binding site of NAD of the Ascaris suum malic enzyme.
Academic Article (31)P NMR spectroscopy senses the microenvironment of the 5'-phosphate group of enzyme-bound pyridoxal 5'-phosphate.
Academic Article The oxidation state of active site thiols determines activity of saccharopine dehydrogenase at low pH.
Academic Article Resolution of pyridoxal 5'-phosphate from O-acetylserine sulfhydrylase from Salmonella typhimurium and reconstitution of apoenzyme with cofactor and cofactor analogues as a probe of the cofactor binding site.
Academic Article Acid-base chemical mechanism of O-acetylserine sulfhydrylases-A and -B from pH studies.
Academic Article The 2'-phosphate of NADP is critical for optimum productive binding to 6-phosphogluconate dehydrogenase from Candida utilis.
Academic Article Chemical mechanism of the fructose-6-phosphate,2-kinase reaction from the pH dependence of kinetic parameters of site-directed mutants of active site basic residues.
Grant STRUCTURE AND MECHANISM OF NAD-MALIC ENZYME
Grant STRUCTURE/MECHANISM OF 6-PHOSPHOGLUCONATE DEHYDROGENASE
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  • Phosphate
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